Impact of Vitamin D on Heart Disease and Total Mortality

关于维生素D缺乏对几种主要疾病的不良影响，有相互矛盾的报道 慢性疾病，如冠心病(CHD)和癌症。据报道，Hypo- 维他命D广泛流行，老年人尤其容易感染。中国维生素D的主要来源 北美洲是通过阳光照射的。对防晒的强调 暴露在降低皮肤癌风险的环境中可能会增加患冠心病的风险。通过使用基督复临安息日 健康研究-2问卷数据及其在全国范围内的10万受试者，我们打算进一步阐明 血清25-羟基维生素D(25-OH-D)与致死性冠心病的关系 术后5年随访总病死率。我们将使用采集的血液样本进行校准 研究确定实际的血清维生素D水平。然后将使用回归校准来预测 血清25羟基维生素D对膳食维生素D暴露、钙摄入量、 阳光和年龄。黑人的结果将与“白人”的结果进行比较，因为皮肤 色素沉着减少了前体转化成的维生素D活性形式的数量。

There are conflicting reports regarding the adverse effects of VITAMIN D (Vit D) deficiency on several major chronic diseases, such as CORONARY HEART DISEASE (CHD) and CANCER. It is reported that HYPO- VITAMINOSIS D is widespread, the ELDERLY being particularly susceptible. The main source of Vit D in North America is through SUNLIGHT EXPOSURE. The emphasis placed on protection from sunlight exposure to reduce skin CANCER risk may be creating an increased risk for CHD. By using the Adventist Health Study-2 Questionnaire data and itsl00,000 subjects countrywide, we intend to further elucidate the relationships between serum 25 hydroxy Vit D(25-OH-D) (the best indicator of Vit D status) and FATAL CHD and TOTAL MORTALITY after 5 years follow-up. We will use blood samples collected for the calibration study to determine actual serum Vit D levels. REGRESSION CALIBRATION will then be used to predict expected values of serum 25 hydroxy Vit D conditonal on exposures to DIETARY VIT D, CALCIUM INTAKE, SUNLIGHT, and AGE. Results for BLACKS will be compared to those of "Whites" because SKIN PIGMENTATION reduces the amount of the active form of Vit D converted from precursors.