Impact of Vitamin D on Heart Disease and Total Mortality

关于维生素D缺乏对几个主要的神经系统的不良影响，有相互矛盾的报道。 慢性疾病，如冠心病和癌症。据悉，HYPO- 维生素D中毒很普遍，老年人尤其易感。维生素D的主要来源 北美是通过阳光照射。强调保护免受阳光照射 减少皮肤癌风险的暴露可能会增加CHD的风险。通过利用基督复临论者 健康研究-2问卷调查数据和它的100，000名受试者在全国范围内，我们打算进一步阐明 血清25-羟基维生素D（25-OH-D）（维生素D状态的最佳指标）与致死性冠心病之间的关系 随访5年后总死亡率。我们将使用采集的血液样本进行校准 研究以确定实际血清维生素D水平。回归校准将用于预测 暴露于膳食维生素D条件下血清25羟基维生素D的预期值，钙摄入量， 阳光，年龄。黑人的结果将与“白人”的结果进行比较，因为皮肤 色素沉着减少了从前体转化的活性形式维生素D的量。

There are conflicting reports regarding the adverse effects of VITAMIN D (Vit D) deficiency on several major chronic diseases, such as CORONARY HEART DISEASE (CHD) and CANCER. It is reported that HYPO- VITAMINOSIS D is widespread, the ELDERLY being particularly susceptible. The main source of Vit D in North America is through SUNLIGHT EXPOSURE. The emphasis placed on protection from sunlight exposure to reduce skin CANCER risk may be creating an increased risk for CHD. By using the Adventist Health Study-2 Questionnaire data and itsl00,000 subjects countrywide, we intend to further elucidate the relationships between serum 25 hydroxy Vit D(25-OH-D) (the best indicator of Vit D status) and FATAL CHD and TOTAL MORTALITY after 5 years follow-up. We will use blood samples collected for the calibration study to determine actual serum Vit D levels. REGRESSION CALIBRATION will then be used to predict expected values of serum 25 hydroxy Vit D conditonal on exposures to DIETARY VIT D, CALCIUM INTAKE, SUNLIGHT, and AGE. Results for BLACKS will be compared to those of "Whites" because SKIN PIGMENTATION reduces the amount of the active form of Vit D converted from precursors.