SWAN Sleep Study II - Chicago (Rush) Site

描述（由申请人提供）：女性在中年时睡眠中断增加，部分原因是年龄本身的影响，但也可能部分原因是更年期过渡，即更年期过渡期间发生的激素、症状和出血的变化。目前修订的提案（Sleep II）将纵向扩展目前资助的、多地点、多种族的中年妇女睡眠横断面研究（Sleep I）。在《睡眠I》中，研究人员对来自全国妇女健康研究（SWAN，一项关于更年期和衰老的纵向研究）的七个研究点中的四个研究点的370名绝经前、绝经前后和绝经后的中年白人、非裔美国人和中国女性进行了实地检查，使用了家庭多导睡眠仪、日常日记和活动记录仪以及自我报告睡眠问卷。在睡眠II中，将使用协调R01机制，对相同的女性样本（年龄在51-62岁之间）进行第二次现场检查，采用相同的程序。一个被广泛引用的睡眠障碍病理生理学启发式模型将被应用于这些纵向数据，以评估这一多民族妇女样本中与更年期相关的睡眠障碍的发展。该模型将急性睡眠障碍归因于诱发因素和诱发因素的综合作用，将慢性睡眠障碍的持久性超越急性应激因素归因于持久因素。

DESCRIPTION (provided by applicant): Sleep disruptions increase during mid-life in women, due in part to the effects of age itself, but also possibly due in part to the menopausal transition, i.e. changes in hormones, symptoms, and bleeding that occur during the menopausal transition. The current, revised proposal (Sleep II) will extend longitudinally the currently funded, multi-site, multi-ethnic cross-sectional study of sleep in midlife women (Sleep I). In Sleep I, field-based examinations were conducted with 370 midlife pre-, peri- and postmenopausal Caucasian, African-American, and Chinese women from four of seven study sites from the Study of Women's Health Across the Nation (SWAN, a longitudinal study of menopause and aging), using in-home polysomnography, daily diaries and actigraphs, and self-report sleep questionnaires. In Sleep II, using a Coordinated R01 mechanism, a second field-based examination will be conducted on the same sample of women (who will be aged 51-62 years), incorporating the same procedures. A widely-cited heuristic model of the pathophysiology of sleep disturbances will be applied to these longitudinal data to evaluate the development of menopause-related sleep disturbances in this multi-ethnic sample of women. This model attributes acute sleep disturbances to the combined effects of predisposing and precipitating factors, and persistence of chronic sleep disturbances beyond the acute stressor to perpetuating factors. The specific aims for this longitudinal assessment of sleep through the menopausal transition are to identify potential: 1) predisposing factors (race, low socioeconomic status, low levels of physical activity, high body mass index, smoking, history of sleep problems, poor health status); 2) precipitating factors (vasomotor symptoms, new adverse life events, rapid increases in follicle stimulating hormone) for acute sleep disturbances during the transition; 3) perpetuating factors (poor sleep hygiene, dysfunctional attitudes and beliefs about sleep, heightened cognitive and physiologic arousal at night, race) for chronic sleep disturbances during the transition; and 4) adverse effects of sleep disturbances on subsequent health status during the early postmenopause (worsening metabolic profile and quality of life, increased hypertension, physical limitations). The public health relevance of this research is to understand better the changes in the sleep of women from different racial and socioeconomic backgrounds and identify risk factors for sleep problems. The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances.