Sleep During the Perimenopause in a Multi-Ethnic Cohort

这项互动式研究项目赠款(IRPG)将在430名女性样本中描述更年期特征和睡眠之间的关系：200名高加索人，150名非裔美国人和80名中国人。尽管中年女性睡眠障碍、失眠和睡眠呼吸障碍的发生率增加，但人们对更年期和睡眠之间的关系知之甚少。血管舒缩症状和激素替代疗法对睡眠的影响表明，睡眠-更年期关系不仅仅是年龄的函数。考虑到睡眠对心理和身体健康的影响，更多地了解中年女性睡眠障碍的原因是很重要的。睡眠障碍与一系列负面健康后果有关，包括生产力和生活质量下降、精神疾病、免疫抑制以及疾病和疾病易感性增加。这项研究的目的是：1)描述多民族中年女性睡眠障碍的特征；2)描述更年期特征与睡眠障碍之间的关系；3)评估相关心理生物学因素对睡眠-更年期关系的影响；4)为未来的纵向研究建立基线数据。正在进行的全国妇女健康研究(SWAN)的七个研究站点中的四个将合作从SWAN队列中招募绝经前和围绝经期妇女的样本。一旦登记参加睡眠研究，参与者将在新的月经周期开始时开始该方案。在方案的第1-3天期间，将在参与者的家中进行动态多导睡眠监测。将在整个周期中收集血管运动症状数据的睡眠日记、活动记录和事件监视器记录。数据还将包括Core Swan五年来关于更年期特征(出血模式、血管舒缩症状、激素水平)和相关心理生物因素的研究数据。回归技术将被用来模拟更年期特征、睡眠和相关的心理生物因素之间的关系。匹兹堡基地将培训研究人员使用睡眠监测设备，并负责处理、评分和存档所有睡眠数据。所有睡眠研究数据，以及Core Swan研究的相关数据，都将由密歇根网站合并和分析。芝加哥大学和加州大学大卫·皮斯分校将共同主持睡眠研究指导委员会。

This interactive Research Project Grant (IRPG) will characterize the relationship between menopausal characteristics and sleep in a sample of 430 women: 200 Caucasian, 150 African- American, and 80 Chinese. Although sleep disruptions, insomnia and the incidence of sleep disordered breathing increase in mid- life women, little is known about the relationship between menopause and sleep. The impact of vasomotor symptoms and hormone replacement therapy on sleep suggests that the sleep- menopause relationship is not merely a function of age. A greater understanding of the causes of sleep disturbances in mid- life women is important, given the impact of sleep on mental and physical health. Sleep disturbances are associated with a host of negative health outcomes including losses in productivity and quality of life, psychiatric morbidity, immunosuppression, and increased vulnerability to illness and disease. The study aims of this IRPG are to: 1) characterize sleep disturbances in a large, multi-ethnic sample of mid-life women; 2) characterize relationships among menopausal characteristics and sleep disturbances; 3) evaluate the influence of relevant psychobiological factors on the sleep-menopause relationship; and 4) establish baseline data for a future longitudinal study. Four of seven study sites from the ongoing Study of Women's Health Across the Nation (SWAN) will collaborate to recruit a sample of pre- and peri-menopausal women from the SWAN cohort. Once enrolled in the Sleep Study, participants will begin the protocol at the start of a new menstrual cycle. Ambulatory polysomnography will be conducted in participants' homes during days 1-3 of the protocol. Sleep diary, actigraphy, and event monitor recordings of vasomotor symptom data will be collected throughout the cycle. Data will also include five years of Core SWAN study data on menopausal characteristics (bleeding patterns, vasomotor symptoms, hormone levels) and related psychobiological factors. Regression techniques will be used to model relationships among menopausal characteristics, sleep, and related psychobiological factors. The Pittsburgh site will train study personnel in the use of sleep monitoring equipment and will be responsible for processing, scoring, and archiving all sleep data. All sleep study data, as well as relevant data from the Core SWAN study, will be merged and analyzed by the Michigan site. The Chicago and UC David PIs will co-chair the Sleep Study Steering Committee.