Epidemiologic Study of the Late Reproductive Years

生育后期的流行病学研究

• 批准号: 7227057
• 负责人: ELLEN W FREEMAN
• 金额: $ 59.86万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-10 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7227057
• 关键词: Accounting; African; African American; Age; Aging; Behavior assessment; Behavioral; Behavioral Symptoms; Blood specimen; Body Weight; CYP19A1 gene; CYP1A1 gene; CYP1A2 gene; CYP1B1 gene; Caucasians; Caucasoid Race; Cohort Studies; Data; Depressed mood; Disruption; Distress; Enrollment; Environmental Risk Factor; Epidemiologic Studies; Estradiol; Estrogen Metabolism; Estrogens; Evaluation; Follicle Stimulating Hormone; Genes; Genetic; Genetic Polymorphism; Healthcare; Hormonal; Hormones; Hot flushes; Individual; Investigation; Lead; Link; Medical; Memory impairment; Menopausal Symptom; Menopausal hot flushes; Menopause; Menstrual cycle; Mental Depression; Methods; Modeling; Morbidity - disease rate; Obesity; Ovarian; Phase Transition; Platelet Factor 4; Postmenopause; Premenopause; Preventive; Progress Reports; Race; Rate; Role; Severities; Sleep; Staging; Symptoms; Testosterone; Therapeutic; Time; Variant; Vasomotor; Woman; Work; cofactor; cohort; day; depressive symptoms; experience; genetic association; inhibin B; innovation; middle age; prospective; psychologic; racial difference; reproductive; trend

DESCRIPTION (provided by applicant): This is a continuation of a prospective cohort study of ovarian aging. The study focuses on hormone dynamics and associated symptoms as premenopausal women enter and move through stages in the transition to menopause. The specific aims are to: 1)) Compare hormone levels and longitudinal trends between African American and Caucasian women; 2) Identify how within-woman trends of the study hormones (estradiol, FSH, LH, Inhibin B, DHEAS, and testosterone) and cofactors such as BMI, race, age, symptoms, et al predict the progression through the transition; 3) Identify associations of hormone dynamics with physical and behavioral symptoms that occur with ovarian aging and identify racial differences in these factors; 4) Identify associations of genetic polymorphisms with levels and longitudinal trends and with menopausal symptoms. Hormone evaluations and a battery of physical and behavioral assessments are collected annually on days 1-6 of two consecutive menstrual cycles or 1 month apart in non-cycling women. Continuation of this cohort study will provide new information on hormone dynamics and their influences on menopausal symptoms through the full menopausal transition. More than 80% of U.S. women experience physical or behavioral symptoms around menopause, with varying degrees of severity and disruption in their functioning, and many of these women seek medical relief for distressing symptoms. The lack of understanding of the contributors to these symptoms and their associations with hormonal factors of ovarian aging is a significant health care problem. Increased understanding of the changes associated with reproductive aging and whether there are racial differences in these changes will lead to better preventive and therapeutic strategies to reduce the short and long term morbidity of women's mid-life and postmenopausal years.

描述（由申请人提供）：这是对卵巢衰老的前瞻性队列研究的延续。这项研究的重点是激素动力学和相关症状，因为妇女在过渡到更年期的过程中进入并经历了各个阶段。具体目的是：1））比较非裔美国人和高加索妇女之间的激素水平和纵向趋势； 2）确定研究激素（雌二醇，FSH，LH，抑制素B，DHEAS和睾丸激素）的女性内部趋势以及BMI，种族，年龄，症状等人的辅助因子如何预测通过过渡的进展； 3）确定激素动力学与卵巢衰老发生的身体和行为症状的关联，并确定这些因素的种族差异； 4）确定遗传多态性与水平和纵向趋势以及绝经症状的关联。每年在两个连续的月经周期的第1-6天收集激素评估和一系列身体和行为评估，或者在非周期女性中相隔1个月。这项队列研究的延续将提供有关激素动态的新信息及其对绝经的影响，对它们对更年期症状的影响。超过80％的美国妇女在更年期周围经历了身体或行为症状，其功能的严重程度和干扰程度不同，许多女性寻求医疗救济因令人痛苦的症状。缺乏对这些症状的贡献者的了解及其与卵巢衰老的激素因素的关联是一个重大的医疗保健问题。对与生殖衰老相关的变化以及这些变化中是否存在种族差异的理解将导致更好的预防和治疗策略，以减少妇女中期和绝经后妇女的短期和长期发病率。