Enzyme Based Wearable Environmental Sensor Badge for Personal Exposure Assessment

用于个人暴露评估的基于酶的可穿戴环境传感器徽章

• 批准号: 7337766
• 负责人: Markus Erbeldinger
• 金额: $ 33.11万
• 依托单位: AGENTASE, LLC
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7337766
• 关键词: Acids; Address; Air; Aldehydes; Calibration; Chemical Agents; Chemical Interference; Chemicals; Chemistry; Class; Color; Communication; Communication Tools; Computer software; Condition; Data; Data Collection; Detection; Development; Development Plans; Devices; Drops; Dust; Elements; Ensure; Environment; Enzymes; Equipment; Evaluation; Event; Facility Construction Funding Category; Feedback; Goals; Hazardous Chemicals; Heating; Heavy Metals; Hour; Humidity; Hydrogen Cyanide; Independent Living; Individual; Isocyanates; Laboratories; Life; Maintenance; Measurement; Measures; Mechlorethamine; Metals; Methods; Monitor; Mustard Gas; Operative Surgical Procedures; Output; Oxidases; Ozone; Performance; Pesticides; Polymers; Population Study; Positioning Attribute; Price; Procedures; Process; Production; Range; Reaction Time; Research; Resistance; Signal Transduction; Solutions; Staging; State Government; Stream; System; Technology; Temperature; Testing; Time; Toxin; United States; United States National Institutes of Health; Wireless Technology; Work; air monitoring; aqueous; base; cost; cyanogen; day; design; design and construction; environmental chemical; enzyme activity; enzyme substrate; field study; hazard; improved; instrument; interest; nerve agent; programs; prototype; sensor; size; vibration; volatile organic compound

DESCRIPTION (provided by applicant): ICx-Agentase aims to develop a continuously operating wearable badge that utilizes biocatalytic sensing elements to monitor chemical toxins in air. The proposed wearable, low maintenance, self-contained device will provide real-time measurements of chemical toxins at the point of contact and will provide wireless communication tools to forward the data to a central data collection station. ICx-Agentase is currently developing a wearable badge for detection of chemical agents with support from the United States Defense Threat Reduction Agency and the United States Army Research Office (W911NF-05-C-0004). At this point we have a fully functional, continuously operating prototype device for detection of nerve agents in air. This technology employs inexpensive sensing elements which need to be replaced periodically. The instrument does not require intensive maintenance or calibration. This technology has been successfully tested in independent live agent tests at an approved United States Government facility. With this three year research effort we aim to increase our detection capabilities and improve this prototype by making it smaller, lighter and cheaper to allow the large environmental population studies. Key features will be: High sensitivity with rapid response time (<2 minutes); Analyte specific quantitative detection (four sensing cartridges for detection of ozone, heavy metals, volatile organic compounds (VOCs) and pesticides, respectively); High resistance to potentially interfering environmental conditions such as temperature and humidity; High resistance to potential chemical interferents; Wearable with global positioning system (GPS) tracking and wireless communication to enable central data collection; Expandable platform technology (each device can support two interchangeable sensing elements for detection of two different exposure classes); Low maintenance; Inexpensive (< $5 operating costs per day - utilize replaceable sensing cartridges); Increase operational lifetime of sensing cartridges to at least 36 hours.

描述(由申请人提供)： ICX-Agentase旨在开发一种可连续操作的可穿戴徽章，该徽章利用生物催化传感元件来监测空气中的化学毒素。拟议的可穿戴、低维护、自给自足的设备将提供接触点化学毒素的实时测量，并将提供无线通信工具将数据转发到中央数据收集站。ICX-Agentase目前正在美国国防威胁降低机构和美国陆军研究办公室(W911NF-05-C-0004)的支持下开发一种用于检测化学毒剂的可穿戴徽章。在这一点上，我们有了一个功能齐全、连续运行的原型设备，用于检测空气中的神经毒剂。这项技术采用了需要定期更换的廉价传感元件。该仪器不需要密集的维护或校准。这项技术已在经批准的美国政府设施的独立活体试剂测试中成功地进行了测试。通过这三年的研究工作，我们的目标是提高我们的检测能力，并通过使其更小、更轻、更便宜来改进这一原型，以便进行大规模环境人口研究。主要特点是：灵敏度高，响应时间快(&lt；2分钟)；分析专用定量检测(分别用于检测臭氧、重金属、挥发性有机化合物(VOC)和杀虫剂的四个感应盒)；对温度和湿度等潜在干扰环境条件的高抵抗力；对潜在化学干扰的高抵抗力；可穿戴全球定位系统(GPS)跟踪和无线通信，以实现中央数据收集；可扩展平台技术(每台设备可支持两个可互换的传感元件，用于检测两个不同暴露级别)；维护成本低；价格低廉(&lt；每天5美元的运营成本-使用可更换的感应盒)；将感应盒的使用寿命提高到至少36小时。