创伤性脑损伤临床试验网络-猫眼课题宝

创伤性脑损伤临床试验网络

批准号：

7289209

负责人：

Ramon Diaz-Arrastia

金额：

$42.3万

依托单位：

UT SOUTHWESTERN MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

2003

资助国家：

美国

项目状态：

已结题

起止时间：

2003-07-01 至 2012-06-30

来源：

https://reporter.nih.gov/project-details/7289209

关键词：

4-Aminopyridine AIDS Dementia Complex AIDS neuropathy Academic Medical Centers Academy Accident and Emergency department Achievement Acquired Immunodeficiency Syndrome Activities of Daily Living Acute Acute Brain Injuries Address Administrator Admission activity Adult Adverse effects Affect African American Aftercare Age Age Distribution Age-Years Alcohols Algorithms Alleles Alzheimer&apos s Disease Ambulatory Care Ambulatory Care Facilities American Amnesia Amobarbital Anesthesia procedures Anesthesiology Anesthetics Aneurysmal Subarachnoid Hemorrhages Antibodies Antiepileptic Agents Appointment Area Arm Injuries Arteriovenous malformation Ascorbic Acid Asia Asian Americans Automobile Driving B-Lymphocytes Back Pain Beds Behavior Behavioral Benzodiazepines Bilateral Biochemical Markers Biological Models Brain Brain Injuries Brain imaging Budgets Burn injury Burning Pain Candidate Disease Gene Caring Case Management Case Mixes Case Series Case Study Caucasians Caucasoid Race Cavernous Hemangioma Cephalic Cerebral Aneurysm Cerebral Cavernous Hemangiomas Cerebrospinal Fluid Cerebrovascular Circulation Cerebrum Cervical Cessation of life Chairperson Characteristics Charge Chicago Chronic Cities Classification Clinic Clinical Clinical Practice Guideline Clinical Psychology Clinical Research Clinical Trials Clinical Trials Network Clinical/Radiologic Clinics and Hospitals Clip Closed head injuries Cognitive Collaborations Coma Commit Communities Community Integration Complication Computer software Condition Conflict (Psychology)Congenital arteriovenous malformation Consent Consult Consultations Continuity of Patient Care Contraceptive Usage Control Groups Country County Craniocerebral Trauma Craniotomy Critical Illness Critical Pathways Critiques DNA Daily Data Data Collection Data Coordinating Center Databases Decubitus ulcer Demyelinations Development Diabetes Mellitus Diabetic Foot Diagnosis Diffuse Disabled Persons Disease Doctor of Philosophy Dose Double-Blind Method Early Ambulation Education Electrodiagnosis Electroencephalography Employment End Point Energy Metabolism Enrollment Epidemic Epidemiologic Studies Epilepsy Equipment Esthesia Ethnic Origin Evaluation Excitatory Amino Acids Faculty Family Fellowship Fibromyalgia Figs - dietary Fistula Flurbiprofen Forensic Medicine Fostering Foundations Functional disorder Funding Funding Agency Gender Gene Transfer Generations Genetic Genetic Polymorphism Glasgow Outcome Scale Glucose Goals Gunshot wound HIV Infections Hair Head Penetrating Missile Injuries Head and neck structure Healed Health Health Policy Health Sciences Health Services Research Hematoma Hematoma, Subdural, Acute Hemorrhage Heterogeneity Heterotopic Ossification Hispanics Home environment Homocysteine Homocystine Hospital Mortality Hospitalization Hospitals Hour Human Human Resources Hydroxychloroquine Hyperhomocysteinemia Hypokalemia Impairment Incidence Independent Living Individual Industry Infection Infusion procedures Injury Inpatients Institutes Institution International Intervention Interview Intestines Intracarotid Intractable Epilepsy Intravenous Invasive Investigation Jail Journals Kidney Language Late Effects Lead Learning Left Length Length of Stay Lesion Letters Levodopa Life Lipid Peroxidation Lipid Peroxides Liquid substance Lobectomy Location Long-Term Care Lorazepam Lower Extremity MMPI Magnesium Magnetic Resonance Imaging Mails Maintenance Maps Marek Disease Measures Medical Medical Education Medical Records Medical Staff Medical center Medicare Medicine Memory Mental Depression Mentors Mesylates Methodist Church Methods Middle Fossa Military Personnel Minor Monitor Monoclonal Antibody R24 Morbidity - disease rate Motor Motor Seizures Multicenter Studies Multicenter Trials Multiple Fractures Multiple Sclerosis Mus Myopathy N(delta)-acetylornithine, -isomer N-dodecanoylglutamic acid, -isomer, sodium salt Names National Institute of Mental Health Natural History Nature Nerve Neurocognitive Neurodegenerative Disorders Neurologic Neurologic Deficit Neurological outcome Neurological rehabilitation Neurologist Neurology Neuromuscular Diseases Neurons Neuropathogenesis Neuropathy Neuropsychology Neurosciences Neurosurgeon Neurosurgical Procedures Neurosyphilis Neurotrophin 3 New York Non-Convulsive Status Epilepticus North America Numbers Nurses Nursing Homes Nursing Models Nursing Research Occupational Therapist Office Visits Operative Surgical Procedures Oral Orthopedics Outcome Outpatients Oxandrolone Pain Pain Measurement Pain Threshold Parents Pathologist Patient Care Patient Discharge Patient Selection Patients Pattern Penicillins Pentobarbital Performance Peripheral Personal Satisfaction Persons Pharmacologic Substance Pharmacotherapy Phase Phase II Clinical Trials Phenobarbital Phenytoin Photometry Physical Medicine Physician Executives Physicians Pilot Projects Placebo Control Placement Planet Mars Plasma Play Population Population Study Post-Concussion Syndrome Post-Head Injury Coma Postdoctoral Fellow Posterior Fossa Potassium Chloride Prevalence Prevention Principal Investigator Procedures Process Production Productivity Prophylactic treatment Prospective Payment System Protocols documentation Provider Psoriatic Arthritis Psyche structure Psychiatry Psychology Psychophysiologic Disorders Publications Published Comment Publishing Purpose Quality of Care Quality of life Questionnaires Randomized Randomized Controlled Trials Range Rate Reaction Readiness Recommendation Recording of previous events Records Recovery Recovery of Function Recruitment Activity Refractory Registries Rehabilitation Centers Rehabilitation Research Rehabilitation therapy Research Research Design Research Ethics Committees Research Institute Research Personnel Research Project Grants Resources Resuscitation Retrospective Studies Review Literature Rheumatoid Arthritis Rheumatology Risk Risk Factors Role Running Rupture Rural SAS SDZ EAA 494 Safety Sales Scanning Science Score Seizures Series Services Severities Site Skin graft Societies Sodium Chloride Source Specialist Speech Spinal Cord Diseases Spinal cord injury Splint Device St. Louis Encephalitis Staging Standards of Weights and Measures Statistical Methods Statistically Significant Structure Subarachnoid Hemorrhage Subgroup Substance abuse problem Succinate-semialdehyde dehydrogenase Sulfasalazine Surgical Management Survivors Swelling Syndrome System Systemic Lupus Erythematosus TBI Patients TFX Taxes Tea Techniques Telemedicine Telephone Tertiary Protein Structure Testing Texas Therapeutic Intervention Third-Party Payer Thromboembolism Time Tissues Toxic effect Training Trauma Traumatic Brain Injury Treatment Protocols Triage Unconscious State Uncontrolled Study United States United States Centers for Medicare and Medicaid Services United States National Institutes of Health Universities University Hospitals Update Vascular Diseases Vehicle crash Venous Thrombosis Ventricular Veterans Vietnam Virginia Visit Washington Wheelchairs Woman Work Writing X-Ray Computed Tomography Zinc abstracting adenoviral-mediated alpha-difluoromethyl-DOPA, -isomer alpha-methylornithine dihydrochloride, -isomer assault austin bariatric surgery base brain morphology brain surgery carina cerebral atrophy clinical research site cohort collaborative trial college community reintegration comparative computerized concept cooperative study cost daily functioning data collection evaluation data collection methodology day demographics design disability experience falls follow-up functional outcomes gallium alloy GF gene therapy handbook handicapping condition healing human prostaglandin D2 receptor human subject improved injured injury prevention instrument interest loss of function male medical schools medical specialties member mesylate mortality multidisciplinary natural hypothermia neurobehavioral neurochemistry neuroimaging neurophysiology neuropsychological neurosurgery older patient patient home care patient registry placebo controlled study potassium-magnesium citrate preference pressure prevent professor prognostic programs prospective psychologic ranpirnase rehabilitation management rehabilitation service repository research and development research clinical testing research study restoration service intervention sex size skills symposium thiazide trafficking trauma centers trauma units treatment duration treatment program trimethylaminocarboxyldihydroboran vitamin therapy willingness

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DESCRIPTION (provided by applicant): This is a revised proposal for a Clinical Site in the "Cooperative multicenter traumatic brain injury clinical trials network." The proposal aims to establish a Traumatic Brain Injury (TBI) Research Center in Dallas, Texas, to be based at Parkland Memorial Hospital (PMH), with the collaboration of the Baylor Institute for Rehabilitation (BIR). Both institutions are nationally recognized for neurosurgical, neurological, and rehabilitation care. Parkland is the major Level I Trauma Center in the North Texas area, serving a population of approximately 5 million. PMH averages approximately 350 admissions for TBI each year, and 140 of these are for moderately severe to severe brain injury. All TBI patients are evaluated by the Physical Medicine and Rehabilitation service, and appropriate rehabilitation follow-up is obtained. The great majority of patients are referred to one of two rehabilitation units, the rehabilitation unit at PMH and BIR. Both the Parkland rehabilitation unit and the TBI unit at BIR are collaborators on this project. The PI, Dr. Eugene George, is Chief of the Neurosurgical Service at PMH. He has experience in multicenter collaborative trials in TBI, subarachnoid hemorrhage, and spinal cord injury. The other collaborators in the project all have an academic and clinical commitment to the care of patients with TBI. Dr. Lisa-Ann Wuermser is director of the Physical Medicine and Rehabilitation service at PMH, and an active investigator on trials on SCI and TBI. Dr. Mary Carlile is director of the TBI Program at BIR, and is widely recognized for excellence in management of these patients. Dr. Ramon Diaz-Arrastia is a neurologist and clinical neurophysiologist who is interested in the mechanisms of brain injury. Dr. Munro Cullum is Director of Neuropsychology at UT Southwestern, and has an extensive record of successful collaborative research in TBI and other neurodegenerative diseases. The concept proposal incorporated into this submission aims to determine the efficacy and value of continuous video-EEG (CVEEG) monitoring in patients with moderately-severe to severe TBI. Recent technical advances have made this possible, and small uncontrolled studies indicate that a significant fraction of patients with TBI have subtle nonconvulsive seizures (NCS), that would not be recognized unless CVEEG is performed. The concept proposal aims to determine whether aggressive treatment of NCS results in improved functional outcome.

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