Traumatic Brain Injury Clinical Trials Network

描述（由申请人提供）：这是一份关于“合作多中心创伤性脑损伤临床试验网络”临床站点的修订提案。该提案旨在与贝勒康复研究所（BIR）合作，在德克萨斯州达拉斯建立一个创伤性脑损伤（TBI）研究中心，该中心将设在帕克兰纪念医院（PMH）。这两家机构都是全国公认的神经外科、神经学和康复护理机构。帕克兰是北德克萨斯地区主要的一级创伤中心，为大约500万人口提供服务。PMH每年平均收治350例TBI患者，其中140例为中重度脑损伤。所有TBI患者均由物理医学和康复服务评估，并获得适当的康复随访。绝大多数患者被转介到两个康复单位之一，即PMH和BIR的康复单位。帕克兰康复中心和BIR的创伤性脑损伤中心都是这个项目的合作者。私家侦探尤金·乔治博士是PMH神经外科主任。他在创伤性脑损伤、蛛网膜下腔出血和脊髓损伤的多中心合作试验方面有丰富的经验。该项目的其他合作者都对TBI患者的护理有学术和临床承诺。Lisa-Ann Wuermser博士是PMH物理医学和康复服务主任，也是脊髓损伤和创伤性脑损伤试验的积极研究者。玛丽·卡莱尔博士是BIR创伤性脑损伤项目的主任，并因其对这些患者的卓越管理而得到广泛认可。Ramon Diaz-Arrastia博士是一名神经学家和临床神经生理学家，他对脑损伤的机制感兴趣。Munro Cullum博士是西南德克萨斯大学神经心理学主任，在创伤性脑损伤和其他神经退行性疾病方面有着广泛的成功合作研究记录。

DESCRIPTION (provided by applicant): This is a revised proposal for a Clinical Site in the "Cooperative multicenter traumatic brain injury clinical trials network." The proposal aims to establish a Traumatic Brain Injury (TBI) Research Center in Dallas, Texas, to be based at Parkland Memorial Hospital (PMH), with the collaboration of the Baylor Institute for Rehabilitation (BIR). Both institutions are nationally recognized for neurosurgical, neurological, and rehabilitation care. Parkland is the major Level I Trauma Center in the North Texas area, serving a population of approximately 5 million. PMH averages approximately 350 admissions for TBI each year, and 140 of these are for moderately severe to severe brain injury. All TBI patients are evaluated by the Physical Medicine and Rehabilitation service, and appropriate rehabilitation follow-up is obtained. The great majority of patients are referred to one of two rehabilitation units, the rehabilitation unit at PMH and BIR. Both the Parkland rehabilitation unit and the TBI unit at BIR are collaborators on this project. The PI, Dr. Eugene George, is Chief of the Neurosurgical Service at PMH. He has experience in multicenter collaborative trials in TBI, subarachnoid hemorrhage, and spinal cord injury. The other collaborators in the project all have an academic and clinical commitment to the care of patients with TBI. Dr. Lisa-Ann Wuermser is director of the Physical Medicine and Rehabilitation service at PMH, and an active investigator on trials on SCI and TBI. Dr. Mary Carlile is director of the TBI Program at BIR, and is widely recognized for excellence in management of these patients. Dr. Ramon Diaz-Arrastia is a neurologist and clinical neurophysiologist who is interested in the mechanisms of brain injury. Dr. Munro Cullum is Director of Neuropsychology at UT Southwestern, and has an extensive record of successful collaborative research in TBI and other neurodegenerative diseases. The concept proposal incorporated into this submission aims to determine the efficacy and value of continuous video-EEG (CVEEG) monitoring in patients with moderately-severe to severe TBI. Recent technical advances have made this possible, and small uncontrolled studies indicate that a significant fraction of patients with TBI have subtle nonconvulsive seizures (NCS), that would not be recognized unless CVEEG is performed. The concept proposal aims to determine whether aggressive treatment of NCS results in improved functional outcome.