ADHD (Attention Deficit Hyperactivity Disorder) after Surgery for Congenital Hear

先天性听力手术后 ADHD(注意力缺陷多动障碍)

基本信息

  • 批准号:
    7286294
  • 负责人:
  • 金额:
    $ 19.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-09-13 至 2011-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Over the past decade the survival of children with congenital heart disease (CHD) has improved significantly, leading to an increasing number of survivors. Recognized sequelae of surgery for congenital heart surgery include residual hemodynamic abnormalities and arrhythmias. It is now being recognized that the neurodevelopmental sequelae of this type of surgery are substantial. Specifically, many school age children are challenged because of problems with inattention and hyperactivity; that is, they appear to have attention deficit hyperactivity disorder (ADHD). There is evidence that ADHD is more prevalent in the post surgery CHD patients than in the general population. In addition, the CHD-ADHD patients seem to be under treated. Thus, the primary aims of this study include 1) to determine the prevalence of ADHD in the population of children with CHD undergoing surgery using cardiopulmonary bypass in infancy or early childhood; 2) to compare the prevalence rates of ADHD associated with age of exposure to cardiopulmonary bypass as well as the effect of multiple exposures to CPB and different adjunctive support techniques that may be utilized; 3) to identify and compare the variety of patient related, operative and postoperative risk factors that could affect the likelihood of developing ADHD, including type of congenital heart defect, genetic substrate, surgical procedure required, operative factors, and perioperative events; and 4) to test the safety and efficacy of stimulant medications used to treat ADHD in a postoperative cardiac population. While studies suggest that many of these children have ADHD and could potentially benefit from the standard stimulant drug therapy effective in most of the population, concerns over cardiac safety has severely limited its use in children with heart disease. As no safety studies of the stimulant drugs in this population have been attempted, we propose a randomized double blind placebo controlled trial of the two most commonly used stimulant medications to determine their efficacy and true level of risk in postoperative cardiac children. This information will allow clinicians to use these potentially effective drugs safely in appropriate cardiac patients, improving the quality of life for these children with special needs. The Children's Hospital of Philadelphia (CHOP) Cardiology Division and Cardiac Center have a distinguished history of clinical innovation and excellence in cardiac care, a high volume program with expertise is all areas of pediatric cardiology and cardiothoracic surgery. The faculty of the CHOP and Cardiac Center are experienced investigators in multicenter clinical trials and studies. The institutional strengths and infrastructure support clinical investigations and enhance the likelihood that the aims and long term goals of the Pediatric Heart Network will be achieved. (End of Abstract).
描述(由申请人提供): 在过去的十年中,先天性心脏病(CHD)儿童的生存率显著提高,导致幸存者人数不断增加。公认的先天性心脏病手术后遗症包括残余血流动力学异常和心律失常。现在人们认识到,这种手术的神经发育后遗症是巨大的。具体来说,许多学龄儿童因为注意力不集中和多动而受到挑战;也就是说,他们似乎患有注意力缺陷多动障碍(ADHD)。有证据表明,ADHD在手术后CHD患者中比在普通人群中更普遍。此外,CHD-ADHD患者似乎治疗不足。因此,本研究的主要目的包括:1)确定婴儿期或幼儿期接受体外循环手术的CHD儿童人群中ADHD的患病率; 2)比较与体外循环暴露年龄相关的ADHD患病率以及多次暴露于CPB和可能使用的不同预防性支持技术的影响; 3)识别和比较可能影响ADHD发生可能性的各种患者相关、手术和术后风险因素,包括先天性心脏缺陷类型、遗传底物、所需外科手术、手术因素和围手术期事件;以及4)测试用于治疗术后心脏病人群ADHD的刺激性药物的安全性和有效性。虽然研究表明,这些儿童中的许多人患有ADHD,并且可能受益于对大多数人群有效的标准兴奋剂药物治疗,但对心脏安全性的担忧严重限制了其在心脏病儿童中的使用。由于没有在这一人群中进行兴奋剂药物的安全性研究,我们建议对两种最常用的兴奋剂药物进行随机双盲安慰剂对照试验,以确定其在术后心脏病儿童中的疗效和真实风险水平。这些信息将使临床医生能够在适当的心脏病患者中安全地使用这些潜在有效的药物,提高这些有特殊需要的儿童的生活质量。费城儿童医院(CHOP)心脏科和心脏中心在心脏护理方面具有卓越的临床创新和卓越的历史,在儿科心脏病学和心胸外科的所有领域都有大量的专业知识。CHOP和心脏中心的教师都是多中心临床试验和研究的经验丰富的研究人员。机构优势和基础设施支持临床研究,并提高了实现儿科心脏网络目标和长期目标的可能性。(End抽象)。

项目成果

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VICTORIA L VETTER其他文献

VICTORIA L VETTER的其他文献

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{{ truncateString('VICTORIA L VETTER', 18)}}的其他基金

Pediatric Heart Disease Network: CHOP Membership
小儿心脏病网络:CHOP 会员资格
  • 批准号:
    6401167
  • 财政年份:
    2001
  • 资助金额:
    $ 19.9万
  • 项目类别:
Pediatric Heart Disease Network: CHOP Membership
小儿心脏病网络:CHOP 会员资格
  • 批准号:
    6795481
  • 财政年份:
    2001
  • 资助金额:
    $ 19.9万
  • 项目类别:
ADHD (Attention Deficit Hyperactivity Disorder) after Surgery for Congenital Hear
先天性听力手术后 ADHD(注意力缺陷多动障碍)
  • 批准号:
    7687445
  • 财政年份:
    2001
  • 资助金额:
    $ 19.9万
  • 项目类别:
Pediatric Heart Disease Network: CHOP Membership
小儿心脏病网络:CHOP 会员资格
  • 批准号:
    6527809
  • 财政年份:
    2001
  • 资助金额:
    $ 19.9万
  • 项目类别:
Pediatric Heart Disease Network: CHOP Membership
小儿心脏病网络:CHOP 会员资格
  • 批准号:
    6949151
  • 财政年份:
    2001
  • 资助金额:
    $ 19.9万
  • 项目类别:
ADHD (Attention Deficit Hyperactivity Disorder) after Surgery for Congenital Hear
先天性听力手术后 ADHD(注意力缺陷多动障碍)
  • 批准号:
    7126959
  • 财政年份:
    2001
  • 资助金额:
    $ 19.9万
  • 项目类别:
ADHD (Attention Deficit Hyperactivity Disorder) after Surgery for Congenital Hear
先天性听力手术后 ADHD(注意力缺陷多动障碍)
  • 批准号:
    7902077
  • 财政年份:
    2001
  • 资助金额:
    $ 19.9万
  • 项目类别:
Pediatric Heart Disease Network: CHOP Membership
小儿心脏病网络:CHOP 会员资格
  • 批准号:
    6652124
  • 财政年份:
    2001
  • 资助金额:
    $ 19.9万
  • 项目类别:
ADHD (Attention Deficit Hyperactivity Disorder) after Surgery for Congenital Hear
先天性听力手术后 ADHD(注意力缺陷多动障碍)
  • 批准号:
    7489910
  • 财政年份:
    2001
  • 资助金额:
    $ 19.9万
  • 项目类别:
POSTOPERATIVE ARRHYTHMIAS: IDENTIFICATION AND MECHANISMS
术后心律失常:识别和机制
  • 批准号:
    3342894
  • 财政年份:
    1983
  • 资助金额:
    $ 19.9万
  • 项目类别:

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