Pediatric Heart Disease Network: CHOP Membership

小儿心脏病网络：CHOP 会员资格

• 批准号: 6401167
• 负责人: VICTORIA L VETTER
• 金额: $ 51万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6401167
• 关键词: adolescence (12-20); arrhythmia; cardiovascular disorder therapy; child (0-11); clinical trials; congenital heart disorder; congestive heart failure; cooperative study; drug screening /evaluation; echocardiography; electronic pacemaker; enalapril; exercise; experimental designs; heart function; heart surgery; human subject; human therapy evaluation; idiopathic dilated cardiomyopathy; information dissemination; magnetic resonance imaging; medical implant science; oxygen consumption; patient oriented research; pediatrics; postoperative state

DESCRIPTION (provided by applicant) As a Clinical Center in the new Pediatric Heart Disease Clinical Research Network (PHDCRN), the Children?s Hospital of Philadelphia (CHOP) will participate collaboratively with the Network to improve outcomes for children with heart disease, provide an evidential base for therapies currently used or considered, develop new therapies, and disseminate that information to the medical community. To achieve this goal, we will address the following aims: Aim 1: Develop an infrastructure and investigational team for to assure full participation in PHDCRN; Aim 2: Develop procedures and policies to assure proper implementation of approved PHDCRN protocols; Aim 3: Fully participate in the development new protocols and dissemination of information to the scientific community. Two protocols are proposed for the PHDCRN?s scientific agenda that emphasize the research strengths of the Cardiology Division, the Cardiac Center and CHOP. The short-term study investigates the use of biventricular pacing or cardiac resynchronization in children with severe congestive heart failure and dilated cardiomyopathy. The primary aim of the study is to evaluate the acute effects of biventricular pacing on cardiac function as measured by oxygen consumption during exercise in a 6-week randomized controlled clinical trial. After the 6-week randomized comparison, all patients are paced and longer-term effects on cardiac function, functional capacity and quality of life will be evaluated out to 12 months. The long-term project investigates whether enalapril (ACE inhibition) can reduce the time-related decline in exercise performance experienced by patients with single ventricle who have undergone the Fontan procedure. The primary aim will be to evaluate the effects of ACE inhibition over a 4-year period on maximal oxygen consumption measured during exercise testing in a double blinded randomized clinical trial design. The Children?s Hospital of Philadelphia Cardiology Division and Cardiac Center has a distinguished history of clinical innovation and excellence in cardiac care, a high volume program with expertise in all areas of pediatric cardiology including cardiac arrhythmias, echocardiography, exercise physiology catheterization including interventions, intensive care, cardiac magnetic resonance imaging, transplantation, and surgery for heart disease. Patient care is integrated through a multidisciplinary Cardiac Center. The faculty of the Cardiac Center are experienced investigators and maintain a highly productive program of multicenter and institutional clinical trials and studies. CHOP has made major investments in the clinical research infrastructure that support essential functions in clinical investigations. These programmatic and institutional strengths support the aims and enhance the likelihood that the long-term goals of the PHDCRN will be achieved.

描述（由申请人提供） 作为新的儿科心脏病临床研究的临床中心 网络（phdcrn），费城儿童医院（CHOP）将会 与网络合作参与以改善儿童的成果 患有心脏病，为目前使用的疗法提供了证据基础或 考虑，开发新疗法并将这些信息传播给 医学界。为了实现这一目标，我们将解决以下目标： 目标1：建立一个基础架构和研究团队以确保完整 参与Phdcrn；目标2：制定程序和政策以确保 正确实施批准的PHDCRN协议；目标3：完全参与 在开发中，新协议和信息传播给 科学界。提出了针对Phdcrn科学的两个协议 强调心脏病学部的研究优势的议程， 心脏中心和切碎。短期研究调查了使用 严重患者的双脑室起搏或心脏重新同步 充血性心力衰竭和扩张的心肌病。主要目的 研究是为了评估双室起搏对心脏的急性影响 通过在6周内运动过程中的氧气消耗来衡量的功能 随机对照临床试验。在进行6周的随机比较之后， 所有患者的节奏和对心脏功能，功能的长期影响 能力和生活质量将被评估到12个月。长期 项目调查了依那普利（ACE抑制）是否可以减少与时间相关的 单身患者经历的运动表现下降 经过Fontan手术的心室。主要目的是 评估4年内ACE抑制对最大氧的影响 在锻炼期间以双盲随机分组测试的消费量 临床试验设计。孩子们的费城心脏病学院医院 部门和心脏中心具有临床创新的杰出历史 和心脏护理卓越，这是一项具有专业知识的大批量计划 小儿心脏病学领域，包括心律不齐，超声心动图， 运动生理导管插入术，包括干预，重症监护， 心脏磁共振成像，移植和心脏手术 疾病。患者护理通过多学科心脏融合 中心。心脏中心的教职员工是经验丰富的调查员和 维持高产的多中心和机构临床计划 试验和研究。 CHOP对临床研究进行了重大投资 支持临床研究中基本功能的基础设施。 这些程序和机构优势支持目标并增强 PHDCRN的长期目标的可能性。