Pediatric Heart Disease Network: CHOP Membership

小儿心脏病网络：CHOP 会员资格

• 批准号: 6401167
• 负责人: VICTORIA L VETTER
• 金额: $ 51万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6401167
• 关键词: adolescence (12-20); arrhythmia; cardiovascular disorder therapy; child (0-11); clinical trials; congenital heart disorder; congestive heart failure; cooperative study; drug screening /evaluation; echocardiography; electronic pacemaker; enalapril; exercise; experimental designs; heart function; heart surgery; human subject; human therapy evaluation; idiopathic dilated cardiomyopathy; information dissemination; magnetic resonance imaging; medical implant science; oxygen consumption; patient oriented research; pediatrics; postoperative state

DESCRIPTION (provided by applicant) As a Clinical Center in the new Pediatric Heart Disease Clinical Research Network (PHDCRN), the Children?s Hospital of Philadelphia (CHOP) will participate collaboratively with the Network to improve outcomes for children with heart disease, provide an evidential base for therapies currently used or considered, develop new therapies, and disseminate that information to the medical community. To achieve this goal, we will address the following aims: Aim 1: Develop an infrastructure and investigational team for to assure full participation in PHDCRN; Aim 2: Develop procedures and policies to assure proper implementation of approved PHDCRN protocols; Aim 3: Fully participate in the development new protocols and dissemination of information to the scientific community. Two protocols are proposed for the PHDCRN?s scientific agenda that emphasize the research strengths of the Cardiology Division, the Cardiac Center and CHOP. The short-term study investigates the use of biventricular pacing or cardiac resynchronization in children with severe congestive heart failure and dilated cardiomyopathy. The primary aim of the study is to evaluate the acute effects of biventricular pacing on cardiac function as measured by oxygen consumption during exercise in a 6-week randomized controlled clinical trial. After the 6-week randomized comparison, all patients are paced and longer-term effects on cardiac function, functional capacity and quality of life will be evaluated out to 12 months. The long-term project investigates whether enalapril (ACE inhibition) can reduce the time-related decline in exercise performance experienced by patients with single ventricle who have undergone the Fontan procedure. The primary aim will be to evaluate the effects of ACE inhibition over a 4-year period on maximal oxygen consumption measured during exercise testing in a double blinded randomized clinical trial design. The Children?s Hospital of Philadelphia Cardiology Division and Cardiac Center has a distinguished history of clinical innovation and excellence in cardiac care, a high volume program with expertise in all areas of pediatric cardiology including cardiac arrhythmias, echocardiography, exercise physiology catheterization including interventions, intensive care, cardiac magnetic resonance imaging, transplantation, and surgery for heart disease. Patient care is integrated through a multidisciplinary Cardiac Center. The faculty of the Cardiac Center are experienced investigators and maintain a highly productive program of multicenter and institutional clinical trials and studies. CHOP has made major investments in the clinical research infrastructure that support essential functions in clinical investigations. These programmatic and institutional strengths support the aims and enhance the likelihood that the long-term goals of the PHDCRN will be achieved.

描述（由申请人提供） 作为新型小儿心脏病临床研究的临床中心 网络 (PHDCRN)、费城儿童医院 (CHOP) 将 与网络合作参与以改善儿童的成果 患有心脏病，为目前使用的疗法提供证据基础或 考虑、开发新疗法并将该信息传播给 医学界。为了实现这一目标，我们将实现以下目标： 目标 1：建立基础设施和研究团队，以确保充分 参与 PHDCRN；目标 2：制定程序和政策以确保 正确实施经批准的 PHDCRN 协议；目标3：充分参与 制定新的协议和向 科学界。为 PHDCRN 的科学性提出了两项​​协议 议程强调心脏病学部的研究优势， 心脏中心和 CHOP。短期研究调查了使用 重症儿童的双心室起搏或心脏再同步 充血性心力衰竭和扩张型心肌病。该组织的主要目标是 研究旨在评估双心室起搏对心脏的急性影响 通过 6 周运动期间的耗氧量来衡量功能 随机对照临床试验。经过 6 周的随机比较后， 所有患者均接受起搏治疗，并对心脏功能、功能性和功能性产生长期影响 能力和生活质量将在 12 个月内进行评估。长期来看 项目调查依那普利（ACE 抑制）是否可以减少时间相关的 单身患者的运动表现下降 接受过 Fontan 手术的心室。主要目标是 评估 4 年期间 ACE 抑制对最大摄氧量的影响 在双盲随机运动测试中测量消耗量 临床试验设计。费城儿童医院心脏病科 科室和心脏中心拥有杰出的临床创新历史 和卓越的心脏护理，一个具有所有专业知识的大容量计划 小儿心脏病学领域，包括心律失常、超声心动图、 运动生理学导管插入术，包括干预、重症监护、 心脏磁共振成像、心脏移植和手术 疾病。通过多学科心脏科整合患者护理 中心。心脏中心的教职员工都是经验丰富的研究人员 维持高效的多中心和机构临床计划 试验和研究。 CHOP在临床研究上进行了大量投资 支持临床研究基本功能的基础设施。 这些计划和机构优势支持目标并加强 PHDCRN 的长期目标实现的可能性。