Adolescent Medicine Trials Network for HIV/AIDS Interve*

描述（由申请人提供）：洛杉矶儿童医院（CHLA）的使命是“通过整合医疗保健、预防服务、医学教育和研究来促进儿童和青少年的健康和福祉，以响应我们社区的需求，并在爱、同情和尊重他人的氛围中。”“自20世纪80年代初以来，CHLA的青少年医学部一直致力于通过与社区合作建立的创新服务模式、研究和培训来降低年轻人的风险。通过这些方案，该司每年向9000多名青年提供保健、心理健康、病例管理、健康教育和药物滥用治疗服务，并参与社区一级的怀孕、艾滋病毒和暴力预防干预。自青少年试验网络（ATM）成立以来，CHLA已将自己确立为一个高产的青少年医学试验单位（ATU），为ATUs在招募和保留临床试验受试者以及产生高质量数据方面的主要任务做出了贡献。在行为试验领域，CHLA的参与和招募人数远远超过其他ATM站点。对于社区预防试验（Connect to Protect(r)）， CHLA是首批完成指数访谈并开始基于地点的简短调查的三个（15个）站点之一。至于治疗性试验，CHLA在招募人数上一直排在前三分之一。我们的网站管理质量反映在我们半年一次的网站访问中始终如一的积极评价。洛杉矶ATU不仅确立了自己作为一个富有成效的ATU的地位，而且通过积极参与委员会和开发新的行为协议，为ATM做出了贡献。在整个项目的五年中，现场PI一直担任ATU主席，并在执行委员会和现场绩效委员会任职。此外，CHLA是少数几个启动ATN协议（atn039）的ATU站点之一。CHLA目前正在制定另一项原始协议，涉及使用手机作为提醒，以解决不遵守规定的问题。以下申请文件表明，洛杉矶儿童医院（CHLA）青少年医学部具备作为ATN站点参与的经验、专业知识和基础设施。我们的核心人员配备计划将使我们能够继续有效地招募和保留治疗，行为和社区试验。此外，我们经验丰富的工作人员将继续积极参与新方案的制定，从而使我们能够继续为ATN的科学议程作出贡献。ATN研究议程与公共卫生特别相关，因为它将大大促进我们对青少年感染艾滋病毒的了解。

DESCRIPTION (provided by applicant): The mission of Children's Hospital Los Angeles (CHLA) is "to advance the health and well-being of children and adolescents by integrating medical care, preventive services, medical education, and research in response to the needs of our community and in an atmosphere of love, compassion, and respect for people. "Since the early 1980's, the Division of Adolescent Medicine at CHLA has focused on reducing risks for young people through innovative models of service, research and training established in partnership with the community. Through these programs, the Division provides health care, mental health, case management, health education, and substance abuse treatment services to over 9000 youth annually, and is involved in community-level interventions for pregnancy, HIV, and violence prevention. Since the inception of the Adolescent Trials Network (ATM), CHLA has established itself as a productive Adolescent Medicine Trials Unit (ATU), contributing to the primary mission of the ATUs in the recruitment and retention of subjects in clinical trials and production of high quality data. In the area of behavioral trials, CHLA has far greater participation and recruitment than any other ATM site. For community prevention trials (Connect to Protect(r)), CHLA is one of the first three (of fifteen) sites to complete the index interviews and begin the brief venue based surveys. As for therapeutic trials, CHLA has consistently been in the top third for recruitment. The quality of our site management is reflected in consistently positive reviews at our semi-annual site visits. The Los Angeles ATU has not only established itself as a productive ATU, but has contributed to the ATM through active involvement in committees and the development of new behavioral protocols. The site PI has been the ATU chair for all five years of this project and served on the Executive and Site performance committees. In addition, CHLA is one of the few ATU sites to have initiated an ATN protocol (ATN 039). CHLA is currently in the process of developing yet another original protocol involving the use of cell phones as reminders to address non-adherence. The following application documents that Children's Hospital Los Angeles (CHLA), Division of Adolescent Medicine has the experience, expertise and infrastructure necessary to participate as a site in the ATN. Our core staffing plans will allow us to continue effective recruitment and retention into therapeutic, behavioral and community trials. In addition our experienced staff will continue to be active in the development of new protocols and thus allow us to continue to contribute to the ATN scientific agenda. The ATN research agenda is of particular relevance to public health, as it will significantly contribute to our understanding of HIV in adolescents.