Adolescent Medicine Trials Network for HIV/AIDS Interve*

描述（由申请人提供）：洛杉矶儿童医院（CHLA）的使命是“通过整合医疗保健，预防服务，医学教育和研究，以满足我们社区的需求，并在爱，同情和尊重的氛围中促进儿童和青少年的健康和福祉。“自1980年代初以来，CHLA的青少年医学部一直致力于通过与社区合作建立的创新服务模式，研究和培训来减少青少年的风险。通过这些方案，该司每年向9 000多名青年提供保健、心理健康、病例管理、健康教育和药物滥用治疗服务，并参与社区一级预防怀孕、艾滋病毒和暴力的干预措施。自青少年试验网络（ATM）成立以来，CHLA已成为一个富有成效的青少年医学试验单位（ATU），为ATU在招募和保留临床试验受试者以及产生高质量数据方面的主要使命做出贡献。在行为试验领域，CHLA的参与和招募比任何其他ATM网站都要多。对于社区预防试验（Connect to Protect（r）），CHLA是完成索引访谈并开始基于场地的简短调查的前三个（十五个）站点之一。至于治疗试验，CHLA一直在招募前三名。我们的网站管理质量反映在我们半年度实地考察的一致好评中。洛杉矶ATU不仅建立了自己作为一个生产ATU，但有助于ATM通过积极参与委员会和新的行为协议的发展。在本项目的所有五年中，现场PI一直担任ATU主席，并在执行委员会和现场绩效委员会任职。此外，CHLA是少数几个ATU站点之一，已经启动了ATN协议（ATN 039）。智利法律援助委员会目前正在制定另一项原始议定书，其中涉及使用手机提醒处理不遵守问题。以下申请文件证明洛杉矶儿童医院（CHLA）青少年医学部具有作为ATN研究中心参与研究所需的经验、专业知识和基础设施。我们的核心人员配置计划将使我们能够继续有效地招募和保留治疗，行为和社区试验。此外，我们经验丰富的工作人员将继续积极参与新协议的制定，从而使我们能够继续为ATN的科学议程做出贡献。ATN研究议程与公共卫生特别相关，因为它将大大有助于我们了解青少年中的艾滋病毒。

DESCRIPTION (provided by applicant): The mission of Children's Hospital Los Angeles (CHLA) is "to advance the health and well-being of children and adolescents by integrating medical care, preventive services, medical education, and research in response to the needs of our community and in an atmosphere of love, compassion, and respect for people. "Since the early 1980's, the Division of Adolescent Medicine at CHLA has focused on reducing risks for young people through innovative models of service, research and training established in partnership with the community. Through these programs, the Division provides health care, mental health, case management, health education, and substance abuse treatment services to over 9000 youth annually, and is involved in community-level interventions for pregnancy, HIV, and violence prevention. Since the inception of the Adolescent Trials Network (ATM), CHLA has established itself as a productive Adolescent Medicine Trials Unit (ATU), contributing to the primary mission of the ATUs in the recruitment and retention of subjects in clinical trials and production of high quality data. In the area of behavioral trials, CHLA has far greater participation and recruitment than any other ATM site. For community prevention trials (Connect to Protect(r)), CHLA is one of the first three (of fifteen) sites to complete the index interviews and begin the brief venue based surveys. As for therapeutic trials, CHLA has consistently been in the top third for recruitment. The quality of our site management is reflected in consistently positive reviews at our semi-annual site visits. The Los Angeles ATU has not only established itself as a productive ATU, but has contributed to the ATM through active involvement in committees and the development of new behavioral protocols. The site PI has been the ATU chair for all five years of this project and served on the Executive and Site performance committees. In addition, CHLA is one of the few ATU sites to have initiated an ATN protocol (ATN 039). CHLA is currently in the process of developing yet another original protocol involving the use of cell phones as reminders to address non-adherence. The following application documents that Children's Hospital Los Angeles (CHLA), Division of Adolescent Medicine has the experience, expertise and infrastructure necessary to participate as a site in the ATN. Our core staffing plans will allow us to continue effective recruitment and retention into therapeutic, behavioral and community trials. In addition our experienced staff will continue to be active in the development of new protocols and thus allow us to continue to contribute to the ATN scientific agenda. The ATN research agenda is of particular relevance to public health, as it will significantly contribute to our understanding of HIV in adolescents.