Children's Hospital Los Angeles Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)
Children's Hospital Los Angeles Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)
批准号:
10599558
负责人:
MARVIN E BELZER
金额:
$39.69万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-09-22 至 2029-06-30
关键词:
AIDS/HIV problemAcquired Immunodeficiency SyndromeAddressAdolescentAdolescent Medicine Trials NetworkAdolescent and Young AdultAdultAdvisory CommitteesAdvocacyAreaCCL21 geneCaliforniaCaringChildCitiesClinicClinicalClinical ResearchClinical ServicesClinical TrialsCohort StudiesCollaborationsCommunitiesComplexCountyDatabasesDevelopmentEducationEnsureEpidemicFamilyFundingFutureGaysGenderGoalsGovernmentHIVHIV/STDHealthHomelessnessHospitalsInterventionInvestigational DrugsLaboratoriesLaboratory ResearchLatinxLeadLeadershipLesbianLesbian Gay Bisexual Transgender QueerLos AngelesMedicalMedicineMental Health ServicesModelingNational Institute of Child Health and Human DevelopmentNational Institute of Drug AbusePediatric HospitalsPharmaceutical ServicesPharmacy facilityPreventionProtocols documentationPublic HealthResearchResearch Project GrantsRiskSecureServicesSiteStructureUniversitiesWorkadult of colorbasecare systemschildren of colorclinical research sitecommunity based servicecommunity engagementcommunity partnershipdesignexperienceinnovationlensmultidisciplinaryoperationparticipant enrollmentpeople of colorpositive youth developmentprevention serviceprogramsprotocol developmentrecruitresearch studysexsubstance use preventiontransgendertreatment servicesyoung adultyoung man
中文摘要
洛杉矶儿童医院(CHLA)
洛杉矶儿童医院(CHLA)正在提议成为洛杉矶财团的牵头地点。这个
主要目标是与Westat合作,作为青少年试验网络(ATN)运营和
协作中心(OCC)成功规划和实施ATN临床研究,以满足
SLC RFA-HD-23-020中概述的优先领域。CHLA将利用Connect的力量来保护
洛杉矶(C2解放军)联盟将领导社区、临床和学术研究咨询委员会
合作伙伴:
1.开展ATN执行委员会和科学领导委员会确定的研究项目;
2.使用我们的社区、学术和临床合作伙伴参与试验的开发
与ATN科学核心合作,以满足青少年和青壮年在以下方面的需求-
艾滋病毒风险或艾滋病毒携带者;
3.促进ATN V内部关于成功招募和登记以下人员的创新战略
参与者通过诊所、学术大学、基于社区的已建立的合作
组织、卫生部门和其他合作伙伴;
4.提供具有本地实验室能力和药房支持的地点;以及
5.通过有意义和持续的社区参与努力建立领导模式,以确保
这项研究反映了Aya在哪里获得预防和护理服务。
我们提议的财团最初将包括9个合作伙伴,他们将把自己的优势和多样性带到一个地点
将包括临床、学术、政府、社区和其他合作伙伴关系的联盟。我们有四个
为艾滋病毒携带者和有艾滋病毒风险的Aya提供护理的临床网站,主要包括LGBTQ Aya of Color
和两个合作伙伴,目前存储着Aya艾滋病毒携带者和艾滋病毒风险的大型数据库:ATN CARE
加州大学洛杉矶分校和NIDA UO1资助的健康青年男性/跨肤色青年研究队列。我们
最初的目标是四个社区组织和洛杉矶县
艾滋病毒和性传播疾病项目公共卫生司。这些团体和我们阿雅社区的代表
顾问委员会将形成一个代表我们社区的创新领导结构,并能够
通过协议审查、新协议开发以及招聘和指导提供领导
留存。基于数十年来对Aya的临床服务和研究经验,我们建议的LOS
洛杉矶ATN V财团非常适合加入OCC和其他城市财团。CHLA拥有非凡的
在未来的临床试验中可能需要获得Aya,数十年来正在进行的社区合作伙伴关系,以及
在招募和留住难以接触到AYA的临床试验方面有出色的记录,包括复杂的
需要研究新药(IND)、研究实验室和药房服务的医疗干预。
英文摘要
ABSTRACT Children's Hospital Los Angeles (CHLA)
Children's Hospital Los Angeles (CHLA) is proposing to be the lead site for the Los Angeles Consortium. The
primary aim is to collaborate with Westat as the Adolescent Trials Network (ATN) Operations and
Collaborations Center (OCC) to successfully plan and implement ATN clinical research studies to meet the
priority areas as outlined in SLC RFA-HD-23-020. CHLA will leverage the strength of the Connect to Protect
Los Angeles (C2PLA) Coalition to lead a Research Advisory Committee of community, clinical, and academic
partners to:
1. Conduct the Research Projects identified by the ATN Executive and Scientific Leadership Committees;
2. Participate in the development of trials using our community, academic, and clinical partners in
conjunction with the ATN Scientific Core to meet the needs of adolescents and young adults (AYA) at-
risk for or living with HIV;
3. Contribute to innovative strategies within ATN V regarding successful recruitment and enrollment of
participants through established collaborations among clinics, academic universities, community-based
organizations, health departments, and other partners;
4. Provide sites with local laboratory capacity and pharmacy support; and
5. Establish a leadership model with meaningful and sustained community engagement efforts to ensure
that research studies reflect where AYA are accessing prevention and care services.
Our proposed consortium will initially include nine partners who will bring their strength and diversity to a site
consortium that will include clinical, academic, government, community, and other partnerships. We have four
clinical sites that provide care to AYA living with HIV and at risk for HIV including mostly LGBTQ AYA of color
and two partners that currently house large databases of AYA living with HIV and at risk for HIV: ATN CARES
at UCLA and the NIDA UO1-funded Healthy Young Men/A Trans Youth of Color Study cohort at CHLA. We
have initially targeted four community-based organizations and the County of Los Angeles Department of
Public Health Division of HIV and STD Programs. Representatives of these groups and our AYA community
advisory boards will form an innovative leadership structure that is representative of our communities and can
provide leadership through protocol review, new protocol development, and guidance on recruitment and
retention. Based on decades of experience with clinical services and research with AYA, our proposed Los
Angeles ATN V Consortium is well suited to join the OCC and other city consortia. CHLA has exceptional
access to AYA likely needed in future clinical trials, decades of ongoing community partnerships, and an
outstanding track record for recruiting and retaining hard to reach AYA into clinical trials, including complex
medical interventions requiring investigational new drugs (IND), research laboratories, and pharmacy services.
期刊论文(0)
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会议论文
Children's Hospital Los Angeles Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)
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批准号:10709604
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依托单位:
PK STUDY OF ANTIRETROVIRAL THERAPY REGIMENS CONTAINING TENFOVIR AND ATAZANIVIR
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海外基金