IMMUNOLOGY CORE

免疫学核心

• 批准号: 7002019
• 负责人: W ALLAN WALKER
• 金额: $ 13.71万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7002019
• 关键词: biomedical facility; enzyme linked immunosorbent assay; flow cytometry; immunochemistry; immunology; inflammatory bowel diseases; leukocyte activation /transformation; lymphocyte proliferation; monoclonal antibody; radioimmunoassay; tissue /cell culture; tissue resource /registry; training

The development of IBD is dependent upon the activation of mucosal lymphocyte populations and the production of inflammatory mediators. The central hypothesis of this Center's research program presumes that lymphocytes are activated following induced disruption of the mucosal barrier in conjunction with intrinsic (genetically determined) abnormalities of regulatory mechanisms. In order to effectively define the mechanisms contributing to IBD, it is essential that Center investigators have the tools necessary to obtain immune cell populations, determine their functional properties and assess production of key mediators.

IBD 的发展依赖于粘膜淋巴细胞群的激活和产生 炎症介质。该中心研究计划的中心假设是淋巴细胞 在诱导破坏粘膜屏障后被激活，并与内在的（遗传上的） 确定）调节机制异常。为了有效地界定促进机制 对于 IBD，中心研究人员拥有获得免疫细胞群所需的工具至关重要， 确定它们的功能特性并评估关键介体的产生。