High Resolution EEG/Evoked Potential System

高分辨率脑电图/诱发电位系统

• 批准号: 7247965
• 负责人: JAMES P O'HALLORAN
• 金额: $ 32.73万
• 依托单位: NEUROCOMP SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-09 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7247965
• 关键词: Address; Advanced Development; Amplifiers; Architecture; Auditory; Bilateral; Cerebrum; Clinical; Compatible; Computer software; Computerized Medical Record; Databases; Development; Devices; Diagnostic; Disease; Electrodes; Electroencephalography; Electronics; Elements; Environment; Epilepsy; Equilibrium; Evoked Potentials; Frequencies; Generations; Goals; Guidelines; Head; Human; Infection; Laboratories; Lead; Location; Maintenance; Manuals; Maps; Marketing; Measurement; Mechanics; Monitor; Needles; Noise; Numbers; Patients; Performance; Phase; Pliability; Positioning Attribute; Power Sources; Preparation; Price; Privacy; Process; Production; Protocols documentation; Puncture procedure; Purpose; Range; Reaction Time; Resolution; Risk; Sampling; Scalp structure; Signal Transduction; Site; Skin; Solvents; Source; Standards of Weights and Measures; Stimulus; Stroke; Surface; Syringes; System; Technology; Time; Ultrasonics; Universities; Visual evoked cortical potential; Work; analog; base; clinical application; cost; data modeling; design; digital; electric impedance; human subject; improved; irritation; new technology; open source

DESCRIPTION (provided by applicant): To achieve accurate localization of electrical sources of the human EEG and evoked potentials, the field on the scalp must be sampled at much higher spatial frequency than the 19 positions defined by the standard "10- 20" locations. "High resolution" (64-256 channel) EEG (hrEEG) not only provides greater localization of source generators for experimental purposes but can substantially improve diagnostic and monitoring capability for diseases such as epilepsy and stroke. Despite the availability of biopotential amplifier systems with large numbers of channels, the process of transducing the microvolt level cerebral electrical signals at the scalp surface remains difficult, requiring low and balanced contact impedances to achieve acceptable levels of line frequency (60 Hz) noise. Manual preparation of scalp sites using solvents, abrasives or syringe needles to match amplifier system input requirements is very time consuming and a major impediment to hrEEG application due to the number of channels involved. High system acquisition cost has also substantially inhibited the development and utilization of hrEEG. A low cost, preparation-free, high resolution EEG system will be developed that will entirely eliminate scalp site preparation without the use of costly on-head electronics, shielded recording environment or excessive filtering that can compromise signal integrity. Setup time for clinical and experimental protocols will be reduced to the time required for physical application of electrodes and patient irritation and risk of infection from scalp puncture during abrasion will both be eliminated. The new hrEEG system will be designed to substantially lower system cost by a new type of modular hardware architecture that achieves a highly compact form factor. An open-source software package will feature object-oriented programmability, conferring unprecedented user control and flexibility. An advanced electrode cap system will feature disposable/reusable electrodes, user-serviceability and an associated ultrasonic cleaning system that will reduce operational costs. The proposed new system will lead to increased utilization of hrEEG for experimental and clinical applications. Following first year development, the hrEEG system will be evaluated in human subjects at an independent, university-based EEG laboratory.

描述（由申请人提供）：为了准确定位人体脑电图和诱发电位的电源，必须以比标准“10- 20”位置定义的19个位置高得多的空间频率采样头皮上的场。“高分辨率”（64-256通道）脑电图（hrEEG）不仅为实验目的提供了更大的源发生器定位，而且可以大大提高对癫痫和中风等疾病的诊断和监测能力。尽管有大量通道的生物电位放大器系统，但在头皮表面转导微伏级脑电信号的过程仍然很困难，需要低而平衡的接触阻抗才能达到可接受的线频（60 Hz）噪声水平。使用溶剂，磨料或注射器针头手动准备头皮部位以匹配放大器系统输入要求是非常耗时的，并且由于涉及的通道数量多，是hrEEG应用的主要障碍。高昂的系统购置成本也极大地抑制了hrEEG的开发和利用。一种低成本、无需准备、高分辨率的脑电图系统将被开发出来，它将完全消除头皮部位的准备，而不使用昂贵的头上电子设备、屏蔽记录环境或过度滤波，从而损害信号的完整性。临床和实验方案的设置时间将减少到物理应用电极所需的时间，并且在磨损过程中消除了患者对头皮穿刺的刺激和感染风险。新的hrEEG系统将通过一种新型模块化硬件架构，实现高度紧凑的外形，从而大大降低系统成本。开源软件包将具有面向对象的可编程性，赋予前所未有的用户控制和灵活性。先进的电极帽系统将具有一次性/可重复使用的电极，用户可维护性和相关的超声波清洗系统，这将降低操作成本。提出的新系统将增加hrEEG在实验和临床应用中的利用率。在第一年的开发之后，hrEEG系统将在一个独立的、以大学为基础的脑电图实验室对人类受试者进行评估。