Surgical Monitor for Detection of Spinal Cord Injury

用于检测脊髓损伤的手术监视器

• 批准号: 7414943
• 负责人: HONGXUAN ZHANG
• 金额: $ 6.69万
• 依托单位: INFINITE BIOMEDICAL TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7414943
• 关键词: Algorithms; Caring; Clinical; Clinical Research; Clinical Trials; Complex; Computer software; Data; Detection; Development; Devices; Digital Signal Processing; Equipment; Evaluation; Event; Goals; Human; Human Characteristics; Immune; Immunity; Individual; Injury; Intraoperative Monitoring; Investigation; Learning; Measures; Methods; Monitor; Neurologic; Noise; Numbers; Operating Rooms; Operative Surgical Procedures; Outcome; Paraplegia; Patients; Performance; Phase; Predictive Value; Principal Investigator; Purpose; Qualifying; Rate; Research; Risk; Rodent Model; Signal Transduction; Somatosensory Evoked Potentials; Spinal; Spinal Cord; Spinal cord injury; Standards of Weights and Measures; System; Techniques; Technology; Testing; Time; Translating; Vision; Visual; Wireless Technology; Work; base; computerized data processing; design; experience; improved; instrumentation; next generation; novel; patient safety; research and development; safety net; software development; tool

Somatosensory evoked potential (SEP) monitoring during spinal surgery has been associated with a 61% reduction in major neurological deficits. However, visual interpretation of signals is not always accurate, and a significant learning curve has been demonstrated. Therefore, we embarked on a course to develop a novel SEP monitor equipped with the latest in wireless and digital signal processing technology to continuously monitor spinal cord function. We propose the development of a toolbox of techniques which will significantly advance spinal cord assessment during surgery, including: ¿ Integration of noise reduction via single-sweep rejection and filtering ¿ Investigation of the coherence of individual spectral components of the SEP and ¿ Incorporation of wireless multi-channel stimulation & monitoring ¿ Evaluation of the resulting next-generation real-time monitor in a clinical study It is our vision to translate these hardware and improving the outcome of the patient undergoing

脊柱手术期间的体感诱发电位(SEP)监测与减少61%的 严重的神经缺陷。然而，对信号的视觉解释并不总是准确的，这是一项重要的学习 曲线已被演示。 因此，我们开始着手开发一种配备了最新无线和数字技术的新型SEP监护仪 信号处理技术，可持续监测脊髓功能。我们建议开发一个工具箱 将显著推进手术期间脊髓评估的技术，包括： ？通过单扫频抑制和滤波实现降噪集成 研究了SEP的各个光谱分量的相干性和 ？整合无线多通道刺激和监测 在临床研究中对下一代实时监护仪的评估 我们的愿景是将这些硬件和 改善患者接受手术的结局

项目成果

Spinal cord integrity monitoring by adaptive coherence measurement.

• DOI: 10.1016/j.jneumeth.2010.07.035
• 发表时间: 2010-10-30
• 期刊: JOURNAL OF NEUROSCIENCE METHODS
• 影响因子: 3
• 作者: Sherman, D. L.;Wuyyuru, V.;Brooke, M. Jason;Zhang, H. X.;Sepkuty, J. P.;Thakor, N. V.;Natarajan, A.;All, A. H.
• 通讯作者: All, A. H.