Evoked Potential Monitor for Traumatic Brain Injury

描述（由申请人提供）：创伤性脑损伤（TBI）导致美国每年约150，000人死亡。估计有103 000名幸存者，其中大多数人住院时间很长，留下严重后遗症。TBI与患者及其家人的严重情绪困扰有关，每年给国家带来483亿美元的经济负担。 TBI的后果是迅速和毁灭性的。迫切需要对这些危重患者进行可靠的连续神经监测。因此，我们的第一阶段目标是研究使用定量诱发电位（qEP）分析来检测和监测TBI后脑损伤的演变。我们建议开发一种新的qEP系统的基础上，一个强大的正弦建模算法称为ESPRIT。该系统预期用于捕获由于损伤引起的信号分量变化。我们将基于啮齿动物模型中颅内压升高和脑灌注压降低的相关性，评价qEP分析表征急性脑损伤的能力。此外，我们将观察qEP分析的能力，以说明神经功能的结果后72小时测量的可膨胀的肿块病变。 如果我们的第一阶段工作取得成功，我们设想第二阶段的工作重点是该技术的临床验证。我们的长期目标是建立qEP分析作为改善TBI受害者护理的神经诊断工具。

DESCRIPTION (provided by applicant): Traumatic Brain Injury (TBI) results in approximately 150,000 deaths per year in the United States. Most of the estimated 103,000 survivors are subjected to a prolonged hospital course and significant sequelae. TBI is associated with significant emotional distress for the patient and their family, and an economic burden of $48.3 billion per year to the nation. The consequences of TBI are rapid and devastating. There is a pressing need for reliable continuous neurological monitoring of such critical patients. Therefore, our Phase I goal is to investigate the use of quantitative Evoked Potential (qEP) analysis to detect and monitor the evolution of brain injury after TBI. We propose to develop a novel qEP system based on a powerful sinusoidal modeling algorithm known as ESPRIT. This system is intended to capture signal component changes due to injury. We will evaluate the ability of the qEP analysis to characterize acute cerebral injury, based on correlation with elevation of intracranial pressure and reduction of cerebral perfusion pressure in a rodent model. Further, we will observe the ability of qEP analysis to prognosticate the neurological outcome measured 72-hours after the introduction of an expansible mass lesion. If our Phase I effort is successful, we envision a Phase II effort focused on clinical validation of the technology. It is our long-term goal is to establish qEP analysis as a neurodiagnostic tool for improving the care of TBI victims.