Software toolbox for analysis of neural spike train data

描述(由申请人提供)：项目摘要：了解神经元，神经系统的专门细胞如何编码和处理信息仍然是神经科学家的主要目标。提高对神经密码的理解将对神经科学和临床神经学产生巨大影响。现有的神经假体将得到改进，一系列新的神经假体将敞开大门。美国国立卫生研究院发现，在生物医学研究的许多领域取得进展的一个重大障碍是现有计算工具的不足。R.C.Electronics建议进行研究和开发，以开发一种商业棘波序列分析软件产品，为神经科学家提供可扩展、标准化、开放和协作的复杂、最先进的单单元和多单元棘波序列分析工具套件。R.C.电子公司建议既实施标准的、成熟的尖峰序列分析技术，也实施新的、较新的策略。该工具箱将建立在MatLab中，便于用户扩充和算法共享。该项目的长期目标是生产一种产品，不仅提供高质量的尖峰分析能力，而且促进新方法的开发和方法比较的研究。拟议的软件对神经科学研究具有广泛的适用性，包括生理学和病理生理学，包括旨在研究艾滋病毒感染后大脑神经功能的研究。 相关性：神经科学研究人员正在努力开发医学应用程序，例如，允许一个人通过“读取”神经系统的专门细胞神经元的电活动来控制计算机光标或机器人。基础研究包括观察和分析数百个神经元的同时活动。该项目为这一研究领域提供了一套用于这类数据的新的计算工具，并提供了一个促进计算工具共享的平台，以进一步推动这一重要研究领域的发展。

DESCRIPTION (provided by applicant): Project Summary: Understanding how neurons, the specialized cells of the nervous system code and process information continues to be a major goal of neuroscientists. Improved understanding of the neural code will have a huge impact on both neuroscience and clinical neurology. Existing neural prosthetics will be improved and the door will open on a whole host of new neural prosthetics. The National Institutes of Health have identified that a significant roadblock to progress in many areas of biomedical research is attributable to deficiencies in currently available computational tools. R.C. Electronics proposes research and development leading to a commercial spike train analysis software product that will provide neuroscientists with a sophisticated, state-of-the-art, single-unit and multi-unit spike train analysis tool suite that is extendable, standardized, open and collaborative. R.C. Electronics proposes to implement both standard, well-established spike train analysis techniques as well as novel, more recent strategies. The toolbox will be built in MATLAB for easy user augmentation and algorithm sharing. The long-term goals of this project are to produce a product that will not only provide a high-quality spike analysis capability, but also facilitate the development of new methods and research into method comparisons. The proposed software has a broad applicability to neuroscience research both physiology and pathophysiology, including research aimed at studying the neuronal function of the brain following HIV infection. Relevance: Neuroscience researchers are working to develop medical applications that will allow a person, for example, to control a computer cursor or robot based on "reading" the electrical activity of neurons, the specialized cells of the nervous system. The basic research involves observing and analyzing the simultaneous activity of hundreds of neurons. This project offers this field of research a new set of computational tools for this kind of data and a platform that promotes sharing of computational tools to further advance this important field of research.