Physiologic Regulation of Hematopoiesis by Notch

Notch对造血的生理调节

• 批准号: 7485362
• 负责人: Nadia Carlesso
• 金额: $ 37.88万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-15 至 2008-08-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7485362
• 关键词: Address; Adult; Affect; Animals; Basic Science; Biological Assay; Bone Marrow; Bone Marrow Transplantation; CDKN1A gene; Cell Cycle; Cell Cycle Progression; Cell Cycle Regulation; Cell Fate Control; Cell Line; Cells; Clinical; Clonal Expansion; Coculture Techniques; Complex; Comprehension; Condition; Coupling; Cues; Data; Development; Disease; Down-Regulation; Equilibrium; F Box Domain; Genes; Genetic Transcription; Goals; Hematology; Hematopoiesis; Hematopoietic; Homeostasis; Human; Infection; Inflammation; Inflammatory; Injection of therapeutic agent; Investigation; Knock-out; Leukemoid Reaction; Leukocytes; Ligands; Link; Mediating; Modeling; Molecular; Mus; Myelogenous; Pancytopenia; Pathway interactions; Phase; Phenotype; Physiological; Play; Process; Protein Overexpression; Range; Recombinants; Regulation; Role; SKP2 gene; Signal Pathway; Signal Transduction; Skp2 Proteins; Solid; Staging; Stem cells; Stress; Testing; Therapeutic; Transcriptional Activation; Transplantation; Up-Regulation; Work; exhaust; exhaustion; improved; in vitro Model; in vivo; in vivo Model; inhibitor/antagonist; insight; kinase inhibitor; leukemia; notch protein; novel; novel therapeutics; oncoprotein p21; p27 Cell Cycle Protein; p27 Enzyme Inhibitor; progenitor; response; retroviral transduction; self-renewal; size; stem