Child Maltreatment, HPA axis and ANS activity, and Youth Aggression

儿童虐待、HPA 轴和 ANS 活动以及青少年攻击行为

• 批准号: 7295854
• 负责人: ELANA B GORDIS
• 金额: $ 7.55万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-14 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7295854
• 关键词: Accounting; Acute; Adolescence; Adolescent; Adolescent Development; Adrenal Glands; Adrenergic Agents; Adult; Advocate; Affect; Aggressive behavior; Autonomic nervous system; Behavior; Biological; Biological Assay; Censuses; Characteristics; Child; Child Abuse and Neglect; Child Development; Chronic; Conflict (Psychology); Data; Data Analyses; Data Collection; Development; Emotional; Emotional Stress; Exhibits; Exposure to; Face; Family; Family Violence; Funding; Goals; Hydrocortisone; Hypothalamic structure; Investigation; Joints; Knowledge; Lead; Learning; Link; Measurement; Measures; Mediating; Nature; Outcome; Parents; Participant; Pituitary Gland; Play; Protocols documentation; Psychosocial Stress; Recording of previous events; Recruitment Activity; Research; Research Personnel; Role; Route; Saliva; Salivary; Sampling; Severities; Stress; Sympathetic Nervous System; System; Time; Trauma; Trier Social Stress Test; Youth; adrenergic; alpha-amylase; attenuation; base; biological adaptation to stress; child protective service; experience; hypothalamic-pituitary-adrenal axis; maltreated children; maltreatment; psychosocial; response; salivary assay; social; social stress; stressor

DESCRIPTION (provided by applicant): A history of child maltreatment is linked to a host of negative outcomes during adolescence, including aggression and delinquency. One possible route by which maltreatment may affect adolescent functioning is via alterations of the biological stress response. The trauma of child maltreatment may cause dysregulation of biological stress response systems, including attenuation of response systems over time in the face of chronic maltreatment. Low activity in the biological stress responses has been linked with aggression and delinquency. Alternatively, acute maltreatment may lead to sensitization to subsequent interpersonal stress and emotional dysregulation. The biological stress response comprises two key systems: (1) the autonomic nervous system (ANS), which includes the sympathetic nervous system (SNS) and adrenergic activity more specifically, and (2) the hypothalamic pituitary-adrenal (HPA) axis. Most research on the role of the stress response in atypical development examines only one of these systems at a time, thus limiting knowledge about the combined role these related systems play in linking the traumatic stress of maltreatment with negative outcomes. The proposed study is a secondary analysis of data already collected. The goal is to examine the effects of child maltreatment on the adrenergic component of the biological stress response and to add that information to data on HPA axis function collected from the same sample. The project would allow examination of the combined roles of both systems in the link between child maltreatment experiences and adolescent aggression and delinquent behavior. This study is a secondary analysis of data collected from participants in a previously funded R01 study of the effects of maltreatment on adolescent development. Participants include 303 adolescents recruited based on having recent substantiated referrals to child protective services, and 151 comparison youth recruited from the same or comparable Census blocks. A parent or guardian of each youth also participated. The current application focuses on the second wave of 3 waves of data collection. Adolescents participated in a standardized social stress protocol (The TSST, Kirschbaum et al., 1993) and provided two saliva samples before and six after the stressor. Assays are conducted for cortisol as funded by the R01 study. The current application is to conduct assays of salivary alpha-amylase (AA), a marker of adrenergic activity. Thus, the application would allow not only the investigation of salivary AA as a function of family violence exposure and observed family conflict, but examination of how both biological stress response systems jointly account for aggression and delinquent behavior.

描述（由申请人提供）：虐待儿童的历史与青春期的一系列负面结果有关，包括侵略和犯罪。虐待可能影响青少年功能的一个可能途径是通过改变生物应激反应。虐待儿童的创伤可能导致生物应激反应系统失调，包括在长期虐待面前反应系统随着时间的推移而减弱。生物应激反应的低活性与侵略和犯罪有关。另外，急性虐待可能导致对随后的人际压力和情绪失调的敏感。生物应激反应包括两个关键系统：（1）自主神经系统（ANS），其更具体地包括交感神经系统（SNS）和肾上腺素能活动，以及（2）下丘脑垂体-肾上腺（HPA）轴。大多数关于压力反应在非典型发育中的作用的研究一次只检查这些系统中的一个，从而限制了对这些相关系统在将虐待的创伤压力与负面结果联系起来方面所起的综合作用的了解。拟议的研究是对已收集数据的二次分析。我们的目标是研究儿童虐待对生物应激反应的肾上腺素能成分的影响，并将该信息添加到从同一样本收集的HPA轴功能数据中。该项目将允许检查两个系统在儿童虐待经历与青少年攻击和犯罪行为之间的联系中的综合作用。这项研究是从先前资助的R 01研究中收集的数据的二次分析，该研究是关于虐待对青少年发展的影响。参与者包括303名青少年招募的基础上有最近证实转介儿童保护服务，和151个比较青年从相同或可比的人口普查块。每个青年的父母或监护人也参加了会议。当前应用程序侧重于3波数据收集中的第二波。青少年参加了标准化的社会压力协议（TSST，Kirschbaum等人，1993年），并提供了两个唾液样本之前和六个后的压力。根据R 01研究的资助，对皮质醇进行测定。目前的应用是进行唾液α-淀粉酶（AA），肾上腺素能活性的标志物的测定。因此，该应用程序将允许不仅调查唾液AA作为家庭暴力暴露和观察到的家庭冲突的函数，但检查两个生物应激反应系统如何共同占侵略和犯罪行为。