小鼠多种 BDNF 转录亚型的定位和血清素调节-猫眼课题宝

小鼠多种 BDNF 转录亚型的定位和血清素调节

批准号：

7258654

负责人：

ANNE MILASINCIC ANDREWS

金额：

$6.66万

依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

依托单位国家：

美国

项目类别：

财政年份：

2007

资助国家：

美国

项目状态：

已结题

起止时间：

2007-05-09 至 2009-04-30

来源：

https://reporter.nih.gov/project-details/7258654

关键词：

Accounting Address Adult Alzheimer&apos s Disease Antidepressive Agents Anxiety Anxiety Disorders Atrophic Behavior Behavioral Brain Brain Diseases Brain Stem Brain region Brain-Derived Neurotrophic Factor Chronic Chronic stress Code Complex Degenerative Disorder Development Disruption Drug abuse Environmental Risk Factor Epigenetic Process Exons Future Genbank Gene Expression Genes Genetic Transcription Genetically Engineered Mouse Hippocampus (Brain)Human Individual Investigation Learning Maps Mediating Memory Mental Depression Messenger RNA Molecular Mus Neurons Numbers Pattern Personality Traits Phenotype Play Population Predisposition Protein Isoforms Proteins Quantitative Reverse Transcriptase PCR RNA Splicing Range Rattus Regulation Role Schizophrenia Seizures Selective Serotonin Reuptake Inhibitor Serotonin Signal Pathway Signal Transduction Stress Structure Time Transcript Transcriptional Regulation Tricyclic Antidepressive Agents Variant cell type clinically relevant conditioned fear design frontal lobe mood regulation mouse model neurogenesis novel therapeutics promoter response reuptake serotonergic regulation serotonin receptor serotonin transporter transcription factor

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DESCRIPTION (provided by applicant): Understanding the modulation of individual BDNF mRNA splice variants by two clinically relevant forms of reduced serotonin reuptake will facilitate our understanding of the role of BDNF in the regulation of mood and anxiety-related behavior. It will also assist us in addressing long-range questions such as why BDNF is subject to complex transcriptional regulation and how this is reflected in different BDNF protein levels in specific subregions or neuronal subtypes in psychiatric and degenerative brain disorders? Ultimately, we anticipate that having the capability to selectively modulate BDNF at the level of transcription in different cell types and brain regions will be a powerful avenue for the future development of novel therapeutics for the treatment of depression, anxiety disorders and Alzheimer's disease.

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