Mapping and Serotonergic Regulation of Multiple BDNF Transcript Isoforms in Mice

描述(由申请人提供)：了解两种临床相关形式的5-羟色胺再摄取减少对单个BDNF mRNA剪接变体的调节将有助于我们理解BDNF在调节情绪和焦虑相关行为中的作用。它还将帮助我们解决长期的问题，例如为什么BDNF受到复杂的转录调控，以及这如何反映在精神和退行性脑疾病中特定亚区或神经元亚型的不同BDNF蛋白水平？最终，我们预计，拥有在不同细胞类型和大脑区域中选择性地在转录水平上调节BDNF的能力，将是未来开发治疗抑郁症、焦虑症和阿尔茨海默病的新疗法的有效途径。

DESCRIPTION (provided by applicant): Understanding the modulation of individual BDNF mRNA splice variants by two clinically relevant forms of reduced serotonin reuptake will facilitate our understanding of the role of BDNF in the regulation of mood and anxiety-related behavior. It will also assist us in addressing long-range questions such as why BDNF is subject to complex transcriptional regulation and how this is reflected in different BDNF protein levels in specific subregions or neuronal subtypes in psychiatric and degenerative brain disorders? Ultimately, we anticipate that having the capability to selectively modulate BDNF at the level of transcription in different cell types and brain regions will be a powerful avenue for the future development of novel therapeutics for the treatment of depression, anxiety disorders and Alzheimer's disease.