CORE--Shared Resources Chemical Library

核心--共享资源化学库

• 批准号: 7231446
• 负责人: Jeffrey W Smith
• 金额: $ 14.29万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7231446
• 关键词: biomedical facility; chemical registry /resource; combinatorial chemistry; neoplastic process; small molecule

DESCRIPTION (provided by applicant): The long-term objective of the Cancer Center's Chemical Library Screening Facility is to provide new chemical tools for elucidating the basic mechanisms that underlie tumor onset and progression, and to provide lead chemical compounds for initiation of the development of anti-tumor drugs. Small molecule agonists and antagonists have proven to be invaluable tools for solving problems in biology. Since high-throughput screening is not widely available at academic institutions, this facility will provide a new and unique approach toward understanding and combating cancer. The Cancer Center's Chemical Library Screening Facility was founded in mid-2002. The facility was built with funds provided by the Institute and from the fund-raising efforts of Principle Investigators. At the present time the Facility is not funded by the CCSG. The rapid success of the Facility, and the anticipated heavy demand for its services provide the rationale for the funding that is requested. The Specific Aims of the Chemical Library Screening Facility are to: 1) Establish and maintain a large chemical library, and an accompanying database, for screening against molecular targets in cancer; 2) Provide consultation to the Faculty of the Cancer Center in the design of high-throughput assays; 3) Provide high throughput screening services to the Faculty of the Cancer Center; and 4) Provide virtual screening capabilities to the Faculty of the Cancer Center.

描述（由申请人提供）：癌症中心化学品的长期目标 库筛选设施是提供新的化学工具，阐明肿瘤发生和发展的基本机制，并提供先导化合物，启动抗肿瘤药物的开发。小分子激动剂和拮抗剂已被证明是解决生物学问题的宝贵工具。由于高通量筛查在学术机构中并不普遍，该设施将为理解和对抗癌症提供一种新的独特方法。癌症中心的化学图书馆筛选设施成立于2002年中期。该设施是利用研究所提供的资金和主要调查员的筹资努力建造的。目前，该基金不是由CCSG供资的。该机制的迅速成功以及预期对其服务的大量需求，为请求提供资金提供了理由。化学库筛选设施的具体目标是：1）建立和维护一个大型化学库，以及一个附带的数据库，用于筛选癌症中的分子靶点; 2）为癌症中心的教职员工提供高通量检测设计方面的咨询; 3） 为癌症中心的教职员提供高通量筛查服务;以及4）为癌症中心的教职员提供虚拟筛查能力。