CORE--Shared Resources Chemical Library

描述(申请人提供)：癌症中心化学品的长期目标 文库筛选设施是为阐明肿瘤发生和发展的基本机制提供新的化学工具，并为启动抗肿瘤药物的开发提供先导化合物。小分子激动剂和拮抗剂已被证明是解决生物学问题的宝贵工具。由于高通量筛查在学术机构并不广泛使用，这一设施将为了解和抗击癌症提供一种新的独特方法。癌症中心的化学图书馆筛查设施成立于2002年年中。该设施是用研究所提供的资金和主要调查人员的筹资努力建造的。目前，该机制不是由协调委员会提供资金的。该机制迅速取得成功，预计对其服务的需求会很大，这为所要求的资金提供了理由。化学图书馆筛查设施的具体目标是：1)建立和维护一个大型化学资料库和一个附属数据库，用于针对癌症中的分子靶标进行筛查；2)在高通量分析的设计方面向癌症中心的教职员工提供咨询；3) 向癌症中心学院提供高通量筛查服务；以及4)向癌症中心学院提供虚拟筛查能力。

DESCRIPTION (provided by applicant): The long-term objective of the Cancer Center's Chemical Library Screening Facility is to provide new chemical tools for elucidating the basic mechanisms that underlie tumor onset and progression, and to provide lead chemical compounds for initiation of the development of anti-tumor drugs. Small molecule agonists and antagonists have proven to be invaluable tools for solving problems in biology. Since high-throughput screening is not widely available at academic institutions, this facility will provide a new and unique approach toward understanding and combating cancer. The Cancer Center's Chemical Library Screening Facility was founded in mid-2002. The facility was built with funds provided by the Institute and from the fund-raising efforts of Principle Investigators. At the present time the Facility is not funded by the CCSG. The rapid success of the Facility, and the anticipated heavy demand for its services provide the rationale for the funding that is requested. The Specific Aims of the Chemical Library Screening Facility are to: 1) Establish and maintain a large chemical library, and an accompanying database, for screening against molecular targets in cancer; 2) Provide consultation to the Faculty of the Cancer Center in the design of high-throughput assays; 3) Provide high throughput screening services to the Faculty of the Cancer Center; and 4) Provide virtual screening capabilities to the Faculty of the Cancer Center.