Relation between Spontaneous BOLD Fluctuations and Brain Connectivity

描述（由申请人提供）： 血氧水平依赖（BOLD）的功能磁共振成像信号表现出自发波动，在各种条件下，即使在没有任务。值得注意的是，这些波动在功能和解剖学相关的大脑区域中是相关的，这表明存在一种内在的组织来支持正在进行的大脑活动。神经系统疾病和精神疾病已被证明以特征性的方式破坏这些波动，有朝一日可能具有诊断和预后价值。这项研究的目的是了解这些自发波动的组织。这不仅将进一步加深我们对健康时大脑功能的理解，还将有助于我们解释疾病中这些信号的干扰。使用自发BOLD波动的数据，将在本fMRI研究中收集，新的方法将被应用于确定优先连接的成员区域之间的内在网络（目标1）和方向性的影响，在这些地区（目标2）。这两条信息是任何网络功能的关键组成部分，从大脑结构到社会互动再到经济。 这项研究的目的是了解人类大脑的内在功能。内在脑活动的改变与各种神经和精神疾病有关。这项研究将为健康和疾病中的大脑功能提供相关信息。

DESCRIPTION (provided by applicant): The blood oxygen level-dependent (BOLD) fMRI signal exhibits spontaneous fluctuations in a variety of conditions, even in the absence of task. Remarkably, these fluctuations are correlated in regions of the brain that are functionally and anatomically related, suggesting an intrinsic organization is present that supports ongoing brain activity. Neurologic disorders and psychiatric diseases have been shown to disrupt these fluctuations in characteristic ways which may one day have diagnostic and prognostic value. The objective of this research is to understand the organization of these spontaneous fluctuations. Not only will this further our understanding of how the brain functions in health, but also how to interpret disturbances in these signals in disease. Using spontaneous BOLD fluctuation data that will be collected in this fMRI study, novel methods will be applied to determine preferential connectivity among member regions in intrinsic networks (Aim 1) and the directionality of influences in these regions (Aim 2). These two pieces of information are key components to how any network functions, from brain architecture to social interactions to economics. The objective of this study is to understand the intrinsic functioning of the human brain. Alterations in intrinsic brain activity are associated with a variety of neurologic and psychiatric diseases. This research will provide information relevant for brain function both in health and disease.