A role for EphB and NMDARs in dendritic spine formation

EphB 和 NMDAR 在树突棘形成中的作用

基本信息

  • 批准号:
    7233124
  • 负责人:
  • 金额:
    $ 2.99万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-06-01 至 2008-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The majority of mature excitatory synapses in the CNS occur on specialized morphologic structures known as dendritic spines, and it is clear from studies in cell culture that the EphB receptor tyrosine kinase and the NMDAR are involved in proper spine and synapse formation. Recent work has also shown that activated EphB can both recruit and modulate the function of NMDARs. Aim 1 of this proposal will determine the steps of dendritic spine morphogenesis that are regulated by EphB receptor signaling by examining and manipulating neurons over time from EphB null mice. Aim 2 will assess the ability of activated EphB to recruit NMDARs in a more complex system, cortical slice culture, using fluorescently-tagged receptors and two-photon microscopy. Finally, the known interaction of EphB and NMDARs suggests a coordinated role during the development of dendritic spines; Aim 3 will directly test for this cooperative activity in cortical slice using pharmacology to manipulate receptor function and two-photon imaging to visualize spine morphology. Increased understanding of these molecular mechanisms is critical in addressing human neurologic diseases whose phenotype include abnormal spine formation, such as Fragile X, Down, and Rett Syndromes.
描述(由申请人提供):

项目成果

期刊论文数量(0)
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MATTHEW S KAYSER其他文献

MATTHEW S KAYSER的其他文献

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{{ truncateString('MATTHEW S KAYSER', 18)}}的其他基金

Molecular and genetic analysis of the juvenile sleep state
青少年睡眠状态的分子和遗传学分析
  • 批准号:
    10177777
  • 财政年份:
    2021
  • 资助金额:
    $ 2.99万
  • 项目类别:
Molecular and genetic analysis of the juvenile sleep state
青少年睡眠状态的分子和遗传学分析
  • 批准号:
    10675049
  • 财政年份:
    2021
  • 资助金额:
    $ 2.99万
  • 项目类别:
Molecular and genetic analysis of the juvenile sleep state
青少年睡眠状态的分子和遗传学分析
  • 批准号:
    10494058
  • 财政年份:
    2021
  • 资助金额:
    $ 2.99万
  • 项目类别:
Molecular and genetic analysis of sleep ontogeny
睡眠个体发育的分子和遗传分析
  • 批准号:
    10201379
  • 财政年份:
    2020
  • 资助金额:
    $ 2.99万
  • 项目类别:
A critical period of sleep required for normal brain development
大脑正常发育所需的关键睡眠期
  • 批准号:
    8805690
  • 财政年份:
    2014
  • 资助金额:
    $ 2.99万
  • 项目类别:
A critical period of sleep required for normal brain development
大脑正常发育所需的关键睡眠期
  • 批准号:
    9120441
  • 财政年份:
    2014
  • 资助金额:
    $ 2.99万
  • 项目类别:
A role for EphB and NMDARs in dendritic spine formation
EphB 和 NMDAR 在树突棘形成中的作用
  • 批准号:
    6935749
  • 财政年份:
    2005
  • 资助金额:
    $ 2.99万
  • 项目类别:
A role for EphB and NMDARs in dendritic spine formation
EphB 和 NMDAR 在树突棘形成中的作用
  • 批准号:
    7097232
  • 财政年份:
    2005
  • 资助金额:
    $ 2.99万
  • 项目类别:

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