Association between prolactin and mammographic density

催乳素与乳房X线密度之间的关联

• 批准号: 7194254
• 负责人: CLAUDIA C LEIRAS
• 金额: $ 4.66万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7194254
• 关键词: Age; Aging; Biological Markers; Breast; Cessation of life; Cross-Sectional Studies; Development; Diagnosis; Differentiation Inducer; Doctor of Philosophy; Event; Exposure to; Fellowship; Foundations; Genes; Genetic; Genetic Polymorphism; Goals; Growth Factor; High Risk Woman; Histologic; Hormonal; Hormones; Incidence; Individual; Lactation; Malignant Neoplasms; Malignant neoplasm of lung; Mammary Gland Parenchyma; Mammographic Density; Measurement; Measures; Menarche; Menopause; Methods; Mitogens; Modification; Names; Numbers; Pattern; Postmenopause; Predisposition; Pregnancy; Premenopause; Prevention strategy; Prolactin; Range; Receptor Gene; Research; Research Design; Risk; Serum; Single Nucleotide Polymorphism; Training; United States; Variant; Woman; Work; age related; base; breast density; cancer epidemiology; cancer risk; career; clinically relevant; concept; density; genetic association; indexing; interest; malignant breast neoplasm; mammary epithelium; receptor; reproductive; theories

DESCRIPTION (provided by applicant): The histologic composition of the breast is reflected mammographically by density and parenchymal pattern. Research suggests that the parenchymal pattern is a result of exposure to past and current hormones as well as reproductive events which influence susceptibility to breast cancer. The variation observed in mammographic density may be a result of the effect of hormones and/or growth factors. One possible hormone is prolactin, which acts directly on mammary epithelium to produce lobuloalveolar development. Prolactin acts as a mitogen and differentiating agent, especially during pregnancy and lactation. The specific objective of this application is to correlate serum prolactin levels and breast density in postmenopausal women using a cross-sectional study design. I also want to examine the genetic variability in the prolactin gene and prolactin gene receptor in order to understand how they may influence breast density. To date, no study has examined the association between prolactin and breast density. Nor has any study examined the association of genetic polymorphisms in the prolactin and its receptor genes and breast density. This training will form the basis of my Ph.D. work in cancer epidemiology and will provide the foundation for my research career.

描述（由申请方提供）：乳腺的组织学组成通过乳腺X线摄影通过密度和实质模式反映。研究表明，实质模式是暴露于过去和现在的激素以及生殖事件的结果，影响乳腺癌的易感性。乳腺X线摄影密度的变化可能是激素和/或生长因子作用的结果。一种可能的激素是催乳素，它直接作用于乳腺上皮细胞以产生小叶肺泡发育。催乳素作为有丝分裂原和分化剂，特别是在怀孕和哺乳期间。本申请的具体目的是采用横断面研究设计，将绝经后妇女的血清催乳素水平与乳腺密度相关联。我还想研究催乳素基因和催乳素基因受体的遗传变异性，以了解它们如何影响乳房密度。到目前为止，还没有研究探讨催乳素和乳腺密度之间的关系。也没有任何研究检查催乳素及其受体基因的遗传多态性与乳腺密度的关联。这将成为我博士学位的基础。我从事癌症流行病学研究，并将为我的研究生涯奠定基础。