New Investigation Initiatives for the Prevention of Complications of Thalassemia

描述（由申请人提供）：儿童纪念医院（CMH）的地中海贫血综合项目致力于通过多学科方法提供最先进的医疗服务，包括持续的血液警戒活动。地中海贫血患者是弱势群体，他们是儿童纪念医院和美国其他主要地中海贫血治疗中心最大的红细胞输血使用者群体。因此，他们仍然面临已知和潜在的血源性病原体以及与输血治疗相关的其他并发症的高风险。本申请将描述CMH对疾病预防控制中心正在开展的地中海贫血血液安全倡议的预期贡献，并将描述当前和拟议的活动，以加强医疗服务，促进疾病和/或输血相关并发症的预防和改进管理方面的研究。作为美国中西部最大的地中海贫血治疗中心，儿童纪念医院的地中海贫血综合项目具有独特的定位，可以在广泛的地理区域为受这种疾病影响的日益多样化的种族和文化人群提供专业知识。相关性：红细胞输注是地中海贫血（一种严重的遗传性血液疾病）治疗的基石。旨在改进血液安全监测的活动对一般公众的健康具有广泛的影响。本申请中提出的项目旨在改善对血源性感染、铁超载和其他输血相关并发症的监测。

DESCRIPTION (provided by applicant): The Comprehensive Thalassemia Program of the Children's Memorial Hospital (CMH) is committed to providing state-of the-art medical service services using a multidisciplinary approach, including ongoing hemo-vigilance activities. Patients with thalassemia are a vulnerable population who comprise the single largest group of red cell transfusion users at Children's Memorial Hospital and other major U.S. thalassemia treatment centers. As such, they remain at high risk from both known and potential blood-borne pathogens and other complications related to transfusion therapy. This application will delineate expected contributions of CMH to ongoing initiatives by the CDC on blood safety in thalassemia and will describe current and proposed activities to enhance medical services and facilitate research in the prevention and improved management of disease- and/or transfusion-related complications. As the largest thalassemia treatment center in the Midwestern United States, the Comprehensive Thalassemia Program of the Children's Memorial Hospital is uniquely positioned to provide expertise over a wide geographic area to an increasingly diverse ethnic and cultural population affected by this condition. Relevance: Red cell transfusions are a cornerstone for the management of thalassemia, a serious inherited blood disorder. Activities directed at improvements in blood safety monitoring have broad implication on the health of the general public. Projects proposed in this application are aimed at improvements in surveillance for blood borne infections, iron overload and other transfusion-related complications.