New Investigation Initiatives for the Prevention of Complications of Thalassemia

项目摘要 儿童纪念医院（CMH）地中海贫血综合项目 致力于提供最先进的医疗服务， 多学科方法，包括正在进行的血液警戒活动。患者 地中海贫血是一个脆弱的人群谁构成的单一最大的群体， 儿童纪念医院和其他美国主要地中海贫血患者的细胞输血使用者 治疗中心。因此，他们仍然处于已知和潜在的高风险之中。 血源性病原体和其他与输血治疗相关的并发症。这 应用程序将描述CMH对正在进行的计划的预期贡献， 疾病预防控制中心关于地中海贫血的血液安全，并将描述目前和拟议的活动， 加强医疗服务，促进预防研究， 疾病和/或输血相关并发症的管理。作为最大的 地中海贫血治疗中心在美国中西部，综合 儿童纪念医院地中海贫血项目具有独特的优势， 在广泛的地理区域内为日益多样化的种族提供专业知识， 受此影响的文化人口。相关性 红细胞输注是地中海贫血管理的基石， 遗传性血液病旨在改善血液安全监测的活动 对公众健康有广泛影响。本报告中提出的项目 应用的目的是改善监测血液传播的感染，铁 超负荷和其他输血相关并发症。

Project Abstract The Comprehensive Thalassemia Program of the Children's Memorial Hospital (CMH) is committed to providing state-ofthe-art medical service services using a multidisciplinary approach, including ongoing hemo-vigilance activities. Patients with thalassemia are a vulnerable population who comprise the single largest group of red cell transfusion users at Children's Memorial Hospital and other major U.S. thalassemia treatment centers. As such, they remain at high risk from both known and potential blood-borne pathogens and other complications related to transfusion therapy. This application will delineate expected contributions of CMH to ongoing initiatives by the CDC on blood safety in thalassemia and will describe current and proposed activities to enhance medical services and facilitate research in the prevention and improved management of disease- and/or transfusion-related complications. As the largest thalassemia treatment center in the Midwestern United States, the Comprehensive Thalassemia Program of the Children's Memorial Hospital is uniquely positioned to provide expertise over a wide geographic area to an increasingly diverse ethnic and cultural population affected by this condition. Relevance Red cell transfusions are a cornerstone for the management of thalassemia, a serious inherited blood disorder. Activities directed at improvements in blood safety monitoring have broad implication on the health of the general public. Projects proposed in this application are aimed at improvements in surveillance for blood borne infections, iron overload and other transfusion-related complications.