Religion, Culture, and HIV Secondary Prevention in India

描述（由申请人提供）：本申请提供了一个研究和培训方案，重点关注与印度艾滋病毒二级预防和心理健康相关的宗教和文化因素。培训目标是发展以下方面的专门知识：(1)定性研究方法，用于建立印度艾滋病毒二级预防和心理健康的文化一体化理论；(2)印度艾滋病毒二级预防干预措施的制定和实施；(3)使用先进的定量方法来评估干预措施。培训将由印度YRG艾滋病研究与教育中心（CARE）的苏尼提·所罗门博士和dr。Michael Merson和Kathleen Sikkema来自美国耶鲁大学。培训将用于设计、实施和评估一项试点干预措施，以促进印度血清不一致夫妇（艾滋病毒阳性的男性和未感染的妻子）的艾滋病毒二级预防和心理健康。在YRG CARE进行的研究的具体目的是：(1)进行形成性研究，以完善艾滋病毒二级预防和心理健康的形成性理论模型，其中包括宗教和文化因素。模型构建的定量测量将进行试点测试。将对20对血清不一致的夫妇进行启发式访谈，并对艾滋病毒阳性的男性和其伴侣感染艾滋病毒的妻子进行单独的焦点小组；(2)建立基于该模型的HIV二级预防干预；(3)对40对血清不一致夫妇进行干预试点测试，评估在治疗环境下进行夫妻干预的可行性。评估将在基线、干预后和3个月随访时完成。A在受试者内部，将使用多元方差分析来评估变化。该奖项将为艾滋病二级预防干预提供具有文化敏感性的理论和干预方案，可通过随机对照干预试验进行评估。该奖项将支持在发展中国家开展全面、有效和可持续的精神卫生干预措施研究的长期目标。

DESCRIPTION (provided by applicant): This application presents a program of research and training that focuses on religious and cultural factors relevant for HIV secondary prevention and mental health in India. The training objectives are to develop expertise in: (1) qualitative research methods that will be used to build a culturally integrated theory for HIV secondary prevention and mental health in India; (2) the development and implementation of secondary prevention interventions for HIV in India; and (3) the use of advanced quantitative methods for evaluating interventions. The training will be supervised by Dr. Suniti Solomon at YRG Center for AIDS Research and Education (CARE) in India and Drs. Michael Merson and Kathleen Sikkema at Yale University in the US. The training will be used to design, implement, and evaluate a pilot intervention for promoting HIV secondary prevention and mental health among serodiscordant couples (HIV-positive males and uninfected wives) in India. The specific aims of the study to be conducted at YRG CARE are: (1) To undertake formative research to refine a formative theoretical model for HIV secondary prevention and mental health that includes religious and cultural factors. Quantitative measures of model constructs will be pilot tested. Elicitation interviews will be conducted with 20 serodiscordant couples and separate focus groups with HIV-positive males and wives whose partners have HIV; (2) To develop an HIV secondary prevention intervention based on the model; and (3) To pilot test the intervention among 40 serodiscordant couples at YRG CARE and evaluate the feasibility of conducting a couple's intervention within the treatment setting. Assessments will be completed at baseline, post-intervention, and 3-month follow-up. A Within subjects Multiple Analyses of Variance will be used to assess changes. The award will provide a culturally sensitive theory and intervention protocol for HIV secondary prevention intervention that can be evaluated through a randomized, controlled intervention trial. The award will support the long-term goal of conducting research on mental health interventions that are comprehensive, effective, and sustainable in developing countries.