Medical Adhesive for Trauma-Free Bandage Removal

用于无创伤去除绷带的医用粘合剂

• 批准号: 7127852
• 负责人: Janice Paige Buchanan
• 金额: $ 17.6万
• 依托单位: UNIVERSITY OF SOUTHERN MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127852
• 关键词: Adhesives; Animal Model; Animals; Artificial skin; Award; Bandage; Biocompatible; Chemicals; Condition; Development; Elderly; Engineering; Event; Excision; Exhibits; Exposure to; Film; Fullerenes; Funding; Glass; Grant; Healed; Health; Human; In Situ; Infection; Kinetics; Letters; Light; Localized; Maryland; Mechanics; Medical; Methods; Mississippi; Modeling; Molecular; Monitor; Morphology; Oxygen; Patients; Performance; Photosensitizing Agents; Phototoxicity; Polymers; Property; Radiation; Rate; Reaction; Reactive Oxygen Species; Research; Research Personnel; Risk; Science; Screening procedure; Seeds; Skin; Standards of Weights and Measures; Sterile coverings; Structure; System; Technology; Temperature; Testing; Time; Trauma; United States National Institutes of Health; Universities; Veterinary Medicine; Virginia; Visible Radiation; Work; Wound Healing; adhesive polymer; base; biocompatible polymer; college; crosslink; design; experience; frailty; fullerene C70; healing; improved; interest; nanomaterials; polybutadiene; professor; programs; prototype; reaction rate; response; skin irritation; transmission process; vapor

DESCRIPTION (provided by applicant): Wound healing technologies are growing rapidly, and advanced dressings are continuing to accelerate healing rates, reduce infection, and significantly improve patient comfort. Each year new dressings are introduced; however, there still exists a need for strongly adhering bandage dressings that will reduce the risk of skin trauma associated with repeated use and skin frailties. This requirement is most important to very young and advancing age patients - where minimizing skin trauma is paramount. This project proposes the development of a new biocompatible polymer - nanomaterial adhesive system which is capable of being switched from a strongly adhering contact (on) state to a low-adhering release (off) state, when activated by visible light. These releasable adhesives would exhibit a significant reduction in peel strength on activation, which results in reduced localized trauma upon removal when compared to conventional dressings. The specific aims of the project include the (1) design and synthesis of new biocompatible acrylic adhesives containing fullerene active compositions; (2) addition of nanomaterials into polymeric systems and optimize additive concentration; (3) radiation crosslinking and monitoring of molecular events - optimize radiation kinetics and light power; (4) characterization of new adhesives - assess the influence of molar mass increase in the mechanical performance as a function of temperature; (5) determination of the moisture vapor transmission rate of prototypes, using the upright-cup test method; and (6) initial screening to estimate skin irritation and phototoxicity of prototype adhesives using an artificial skin model. Addition of fullerene sensitizers and exposure to visible light induces morphology changes in the polymer adhesive due to in-situ generated chemical species, which initiate crosslinking reactions. During this effort, we will also test for the first time the newly discovered metallic nitride fullerene (MNF) species as cross-linking polymer additives. The rate of reactions in this study will be controlled (1) by the percent of additive and (2) by visible light exposure time and lamp power. Adhesive mechanical properties will be evaluated by standard peel and shear tests. Glass transitions, storage and loss modulus will be determined by DSC and DMA analysis.

描述(由申请人提供)：伤口愈合技术正在迅速发展，先进的敷料继续加快愈合率，减少感染，并显著改善患者的舒适性。每年都会推出新的敷料；然而，仍然需要强力粘合绷带敷料，以降低与重复使用和皮肤脆弱相关的皮肤创伤的风险。这一要求对非常年轻和高龄的患者最为重要--在这些患者中，最大限度地减少皮肤创伤是至关重要的。本项目建议开发一种新的生物相容性聚合物-纳米材料粘接系统，当被可见光激活时，该粘接系统能够从强粘合接触(ON)状态切换到低粘附释放(OFF)状态。与传统敷料相比，这些可释放粘合剂在激活时剥离强度显著降低，从而减少了移除时的局部创伤。该项目的具体目标包括：(1)设计和合成含有富勒烯活性成分的新型生物相容性丙烯酸胶粘剂；(2)将纳米材料添加到聚合物体系中并优化添加剂浓度；(3)辐射交联和分子事件监测--优化辐射动力学和光功率；(4)新型胶粘剂的表征--评估摩尔质量增加对机械性能的影响--作为温度的函数；(5)使用直立杯试验法测定原型的湿气透过率；(6)使用人造皮肤模型进行初步筛选，以评估原型胶粘剂的皮肤刺激性和光毒性。富勒烯增敏剂的加入和可见光的照射会导致聚合物胶粘剂的形态发生变化，这是由于原位生成的化学物种引发了交联反应。在这项工作中，我们还将首次测试新发现的金属氮化物富勒烯(MNF)作为交联聚合物添加剂。本研究中的反应速度将由(1)添加剂的百分比和(2)可见光曝光时间和灯的功率控制。粘结剂的机械性能将通过标准的剥离和剪切试验进行评估。玻璃化转变、存储和损耗模数将通过DSC和DMA分析来确定。

项目成果

Selective complexation and reactivity of metallic nitride and oxometallic fullerenes with Lewis acids and use as an effective purification method.

金属氮化物和氧合富勒烯与路易斯酸的选择性络合和反应性，并用作有效的纯化方法。

• DOI: 10.1021/ic9017147
• 发表时间: 2009-12-21
• 期刊: INORGANIC CHEMISTRY
• 影响因子: 4.6
• 作者: Stevenson, Steven;Mackey, Mary A.;Pickens, Jane E.;Stuart, Melissa A.;Confait, Bridget S.;Phillips, J. Paige
• 通讯作者: Phillips, J. Paige

Evidence for singlet-oxygen generation and biocidal activity in photoresponsive metallic nitride fullerene-polymer adhesive films.

• DOI: 10.1021/am900008v
• 发表时间: 2009-04
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: McCluskey, D. Michelle;Smith, Tiffany N.;Madasu, Praveen K.;Coumbe, Curtis E.;Mackey, Mary A.;Fulmer, Preston A.;Wynne, James H.;Stevenson, Steven;Phillips, J. Paige
• 通讯作者: Phillips, J. Paige