Third International Workshop on Seizure Prediction - Freiburg, Germany, 2007

描述（由申请人提供）：癫痫是最常见的神经系统疾病之一，约占世界人口的1%。虽然在这些患者中，约64%的患者可以通过使用一种或多种抗癫痫药物（AED）来控制癫痫发作，但约36%或2000万患者在使用多种AED时仍会发生癫痫发作。癫痫手术是一种适合约8%的难治性癫痫患者的选择。癫痫手术是一个昂贵的选择，虽然，需要一个高度专业化的团队，专门的监测和广泛使用的成像。在美国，每年的癫痫治疗费用为120亿美元，其中大部分是由于难治性癫痫。癫痫发作的不可预测性是癫痫最令人衰弱的方面之一，严重影响患者的安全和生活质量。在过去的20年里，特别是在过去的6年里，一个国际跨学科的努力，包括工程师，物理学家，数学家，癫痫学家，神经外科医生和神经科学家（国际癫痫预测小组），试图定义一个preseizure期间。这一努力有两个目标。第一个目标是实时检测癫痫前期并进行干预以中止即将发生的癫痫发作。第二个目标是了解癫痫发作前的阶段，从而更好地了解癫痫发作的发生。该小组的会议在美国和欧洲轮流举行，以促进和鼓励尽可能多的感兴趣的科学家参与，这种方法可能会增加成功的可能性。该申请寻求支持来自美国的24名研究人员参加第三届癫痫发作预测国际研讨会，研究自动癫痫发作预测，控制和生成机制。研讨会将于2007年9月29日至10月2日在德国的弗赖堡举行，为期4天。研讨会将以癫痫发作预测竞赛为中心，将涉及基础神经科学家，努力将该领域扩展到以机制为重点的研究，并将涉及预测天气等复杂现象的专家。将支持参与的调查人员包括特邀发言人、初级和高级调查人员，包括妇女、种族和少数民族。第三次癫痫发作预测国际讲习班将于2007年9月29日至10月2日在德国的弗赖堡举行，为期四天。在缉获预测、缉获生成和缉获控制领域工作的国际专家将出席这次科学会议。还将邀请从事天气等复杂现象预测的选定个人分享他们的知识和经验。由于两个原因，癫痫发作预测、癫痫发作产生和癫痫发作控制领域是重要的。首先，他们提供了更好地控制癫痫发作的承诺，预测癫痫发作和干预，以中止即将发生的癫痫发作之前，它开始。第二，这些领域的进展为更好地了解缉获量是如何产生的提供了希望。该申请寻求支持来自美国的24名调查员参加会议。将邀请演讲者和初级和高级调查员（包括妇女、种族和少数民族）参加研究。

DESCRIPTION (provided by applicant): Epilepsy is one of the most common neurological disorders affecting approximately 1% of the world's population. While seizures can be controlled through the use of one or more antiepileptic drugs (AEDs) in approximately 64% of these patients, approximately 36% or 20 million patients continue to have seizures on multiple AEDs. Epilepsy surgery is an option suitable for approximately 8% of patients with intractable epilepsy. Epilepsy surgery is an expensive option, though, requiring a highly specialized team, specialized monitoring and extensive use of imaging. In the USA, the annual cost of epilepsy care is USD 12 billion, most of which is due to intractable epilepsy. The unpredictability of seizures is one of the most debilitating aspects of epilepsy, strongly impacting patient safety and quality of life. In the past 20 years, and particularly in the past 6 years, an international interdisciplinary effort involving engineers, physicists, mathematicians, epileptologists, neurosurgeons and neuroscientists (the International Seizure Prediction Group) has sought to define a preseizure period. The goals of this effort are twofold. The first goal is to detect the preseizure period in real-time and intervene to abort an impending seizure. The second goal is to understand the pre-seizure period and in so doing better understand seizure generation. This group's meetings alternate between the USA and Europe in an effort to facilitate and encourage participation of as many interested scientists as possible, an approach that is likely to increase the probability of success. This application seeks support for 24 investigators from the USA working on automated seizure prediction, control, and mechanisms of generation to participate in the Third International Workshop on Seizure Prediction. The workshop will be held in Freiburg, Germany over 4 days from September 29th to October 2nd, 2007. The workshop will be centered on a seizure prediction competition, will involve basic neuroscientists in an effort to expand the field into mechanism-focused research and will involve experts working on the prediction of complex phenomenon such as weather. Investigators whose participation will be supported will include invited speakers, junior and senior investigators including women and racial and ethnic minorities. The Third International Workshop on Seizure Prediction will be convened in Freiburg, Germany over four days from September 29th to October 2nd, 2007. This scientific meeting will be attended by international experts working in the fields of seizure prediction, seizure generation, and seizure control. Selected individuals working on the prediction of complex phenomena such as weather will also be invited to share their knowledge and experience. The fields of seizure prediction, seizure generation and seizure control are important for two reasons. First, they offer the promise of better control of seizures by predicting a seizure and intervening to abort the impending seizure before it starts. Second, progress in these fields offers the promise of a better understanding of how seizures are generated. This application seeks support for 24 investigators from the USA to attend the meeting. Investigators whose participation will be supported will be invited speakers and junior and senior investigators including women and racial and ethnic minorities.