Third International Workshop on Seizure Prediction - Freiburg, Germany, 2007

第三届癫痫预测国际研讨会 - 德国弗莱堡，2007 年

• 批准号: 7336960
• 负责人: HITTEN P ZAVERI
• 金额: $ 2.3万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7336960
• 关键词: Affect; Antiepileptic Agents; Caring; Clinical; Complex; Country; Databases; Development; Educational workshop; Engineering; Epilepsy; Europe; Evaluation; Funding; Generations; Germany; Goals; Group Meetings; Image; Individual; Institution; International; Intractable Epilepsy; Knowledge; Language; Meta-Analysis; Metric; Minority Groups; Monitor; Neurosurgeon; Operative Surgical Procedures; Patients; Population; Probability; Quality of life; Reporting; Research; Research Personnel; Scientist; Seizures; Series; Shapes; Structure; Time; Travel; Weather; Woman; Work; base; cost; day; experience; interest; nervous system disorder; neurophysiology; patient safety; success

DESCRIPTION (provided by applicant): Epilepsy is one of the most common neurological disorders affecting approximately 1% of the world's population. While seizures can be controlled through the use of one or more antiepileptic drugs (AEDs) in approximately 64% of these patients, approximately 36% or 20 million patients continue to have seizures on multiple AEDs. Epilepsy surgery is an option suitable for approximately 8% of patients with intractable epilepsy. Epilepsy surgery is an expensive option, though, requiring a highly specialized team, specialized monitoring and extensive use of imaging. In the USA, the annual cost of epilepsy care is USD 12 billion, most of which is due to intractable epilepsy. The unpredictability of seizures is one of the most debilitating aspects of epilepsy, strongly impacting patient safety and quality of life. In the past 20 years, and particularly in the past 6 years, an international interdisciplinary effort involving engineers, physicists, mathematicians, epileptologists, neurosurgeons and neuroscientists (the International Seizure Prediction Group) has sought to define a preseizure period. The goals of this effort are twofold. The first goal is to detect the preseizure period in real-time and intervene to abort an impending seizure. The second goal is to understand the pre-seizure period and in so doing better understand seizure generation. This group's meetings alternate between the USA and Europe in an effort to facilitate and encourage participation of as many interested scientists as possible, an approach that is likely to increase the probability of success. This application seeks support for 24 investigators from the USA working on automated seizure prediction, control, and mechanisms of generation to participate in the Third International Workshop on Seizure Prediction. The workshop will be held in Freiburg, Germany over 4 days from September 29th to October 2nd, 2007. The workshop will be centered on a seizure prediction competition, will involve basic neuroscientists in an effort to expand the field into mechanism-focused research and will involve experts working on the prediction of complex phenomenon such as weather. Investigators whose participation will be supported will include invited speakers, junior and senior investigators including women and racial and ethnic minorities. The Third International Workshop on Seizure Prediction will be convened in Freiburg, Germany over four days from September 29th to October 2nd, 2007. This scientific meeting will be attended by international experts working in the fields of seizure prediction, seizure generation, and seizure control. Selected individuals working on the prediction of complex phenomena such as weather will also be invited to share their knowledge and experience. The fields of seizure prediction, seizure generation and seizure control are important for two reasons. First, they offer the promise of better control of seizures by predicting a seizure and intervening to abort the impending seizure before it starts. Second, progress in these fields offers the promise of a better understanding of how seizures are generated. This application seeks support for 24 investigators from the USA to attend the meeting. Investigators whose participation will be supported will be invited speakers and junior and senior investigators including women and racial and ethnic minorities.

描述(由申请人提供)：癫痫是最常见的神经系统疾病之一，影响世界人口的约1%。虽然癫痫发作可以通过使用一种或多种抗癫痫药物(AED)来控制，但约有36%或2000万患者在使用一种或多种抗癫痫药物(AED)时继续发作。癫痫手术是一种适合约8%的顽固性癫痫患者的选择。然而，癫痫手术是一个昂贵的选择，需要高度专业化的团队、专门的监测和广泛的成像应用。在美国，每年的癫痫护理费用为120亿美元，其中大部分是由于顽固性癫痫。癫痫发作的不可预测性是癫痫最令人衰弱的方面之一，严重影响患者的安全和生活质量。在过去的20年里，特别是在过去的6年里，一个由工程师、物理学家、数学家、癫痫专家、神经外科医生和神经科学家参与的国际跨学科努力(国际癫痫发作预测小组)试图确定癫痫发作前的时间。这一努力的目标有两个。第一个目标是实时检测潜伏期，并进行干预以中止即将发生的癫痫发作。第二个目标是了解癫痫发作前的时期，从而更好地了解癫痫发作的产生。该小组的会议轮流在美国和欧洲举行，以努力促进和鼓励尽可能多的感兴趣的科学家参与，这一方法可能会增加成功的可能性。本申请寻求支持来自美国的24名研究人员参加第三届癫痫发作预测国际研讨会，他们致力于癫痫发作的自动预测、控制和生成机制。研讨会将于2007年9月29日至10月2日在德国弗莱堡举行，为期4天。研讨会将以癫痫发作预测竞赛为中心，将有基础神经科学家参与，努力将该领域扩展到以机制为重点的研究，并将有从事天气等复杂现象预测的专家参加。将支持其参与的调查人员包括特邀演讲者、初级和高级调查人员，包括妇女以及种族和少数族裔。第三届缉获预测国际研讨会将于2007年9月29日至10月2日在德国弗莱堡举行，为期四天。这次科学会议将由致力于癫痫发作预测、癫痫发作产生和癫痫发作控制领域的国际专家参加。还将邀请选定的从事天气等复杂现象预测的个人分享他们的知识和经验。癫痫发作预测、癫痫发作发生和癫痫发作控制具有重要的意义，原因有二。首先，它们通过预测癫痫发作并在癫痫发作开始前进行干预以中止即将到来的癫痫发作，提供了更好地控制癫痫发作的承诺。第二，这些领域的进展有望更好地了解癫痫发作是如何产生的。本申请寻求来自美国的24名调查人员参加会议。将邀请发言者以及初级和高级调查人员，包括妇女、种族和族裔少数群体，支持他们的参与。