7th International Cerebral Vascular Biology Conference

描述（由申请人提供）：本提案为第七届国际脑血管生物学会议（CVB-2007）申请资金支持。脑血管生物学（CVB）会议是两年一次的会议，为从事中枢神经系统屏障和脑血管生物学研究的科学家和临床医生提供了一个广泛的国际讨论论坛。神经血管单元和血脑屏障已被美国国立卫生研究院确定为神经科学的优先研究领域。CVB-2007的任务是专门“瞄准”这些确定的优先领域。主要目标是提高对脑屏障和神经血管单元的理解，并通过靶向血管病变将这些知识转化为临床适用的脑治疗递送和中枢神经系统疾病管理策略。许多神经系统疾病和病变与明显的脑血管病理（如阿尔茨海默病的脑淀粉样血管病，中风的动脉粥样硬化等）和/或血脑屏障通透性增加有关。它们包括：肿瘤、缺血、高血压、痴呆、癫痫、感染、多发性硬化症和创伤。在神经变性的机制理解的进展还没有找到成功的管道临床翻译。各种潜在治疗方法的临床转化的主要障碍是难以将其传递到受疾病影响的大脑或神经元。CVB会议的既定重点是健康和疾病中的血脑和血csf屏障的机制、调节和建模。CVB-2007的另一个重点将放在转化研究上——追踪从基本机制发现到临床前开发到临床应用的路径。组织者的目标是增加临床医生的参与，包括神经科医生、神经外科医生和神经放射科医生。为了实现这一主要目标，会议的一个重要组成部分将致力于神经血管单元和中枢神经系统屏障在脑疾病中的作用，并计划针对中风、阿尔茨海默病和神经炎症性疾病进行专门的会议。包括脑肿瘤和癫痫在内的其他病理也将在整个会议的各个环节中讨论。这些疾病的健康“负担”是巨大的- CVB-2007将有助于更好地了解神经系统疾病的血管成分，并开发针对这些疾病的更有效的治疗方法。CVB-2007的主要目标是促进在脑血管研究领域工作的研究人员和临床医生之间交流有关科学发现、创新和技术发展的信息。本次会议的重点将是转化研究——从基础机制发现到临床前开发再到临床应用。

DESCRIPTION (provided by applicant): This proposal is a request for funds toward support of the 7th International Cerebral Vascular Biology Conference (CVB-2007). The Cerebral Vascular Biology (CVB) Conferences are bi-annual meetings that provide a broad international discussion forum for scientists and clinicians engaged in research on CNS barriers and cerebral vascular biology. The neurovascular unit and blood brain barrier have been identified by NIH as priority research areas in neurosciences. CVB-2007 mission is to specifically 'target' these identified priority areas. The key objective is to improve the understanding of the brain barriers and the neurovascular unit and to translate this knowledge into clinically applicable strategies for brain therapeutic delivery and management of CNS diseases by targeting vascular pathologies. Many neurological disorders and lesions are associated with prominent cerebrovascular pathology (e.g., cerebral amyloid angiopathy in Alzheimer's disease, atherosclerosis in stroke, etc.) and/or increased BBB permeability. They include: neoplasia, ischemia, hypertension, dementia, epilepsy, infection, multiple sclerosis, and trauma. The advances in mechanistic understanding of neuronal degeneration have not found successful conduits for clinical translation. The major impediment for clinical translation of various potential treatments is difficulty in their delivery to the brain or neurons affected by disease. The established emphasis of CVB conferences is on mechanisms, modulation and modeling of blood-brain and blood-CSF barriers in health and disease. The key additional emphasis of the CVB-2007 will be on translational research - tracing the path from fundamental mechanistic discovery through pre-clinical development to clinical application. The objective of the organizers is to increase the participation of clinicians including neurologists, neurosurgeons, and neuroradiologists. To achieve this primary goal, a significant component of the meeting will be dedicated to the role of the neurovascular unit and CNS barriers in brain diseases with specific sessions planned on stroke, Alzheimer's disease and neuroinflammatory diseases. Other pathologies including brain tumors and epilepsy will also be covered in various sessions throughout the conference. The health 'burden' of these pathologies is immense - the CVB-2007 will contribute to better understanding of vascular component of neurological diseases and to development of more efficacious therapies that target these diseases. The primary objective of the CVB-2007 is to serve as a catalyst for exchange of information on scientific discoveries, innovation, and technology development among researchers and clinicians working in the cerebrovascular research field. The key accent of this meeting will be on translational research - advancing from fundamental mechanistic discoveries through pre-clinical development to clinical applications.