Circuit Weight Training and Blood Pressure Regulation in Prehypertension

高血压前期的循环重量训练和血压调节

基本信息

  • 批准号:
    7189554
  • 负责人:
  • 金额:
    $ 21.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-01-23 至 2010-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Circuit weight training is a specific type of resistance training that incorporates light weights and short rest intervals, and results in beneficial cardiorespiratory and musculoskeletal adaptations. One of the most important adaptations appears to be reduction of arterial pressure, especially for individuals who may be prehypertensive. The overall goal of this project is to document physiological mechanisms modulating arterial pressure and arterial pressure regulation in response to circuit weight training in prehypertensive young adults. The proposed research will test the hypotheses that circuit weight training decreases arterial blood pressure, baseline sympathetic neural activity and arterial stiffness, and increases parasympathetic cardiac control and cardiovagal baroreflex sensitivity in direct proportion to exercise training duration. In order to test these hypotheses, the following specific aims will be addressed: Determine the effects of a 12-week circuit weight training program on 1) resting arterial pressure; 2) sympathetic neural activity; 3) respiratory sinus arrhythmia and cardiovagal baroreflex sensitivity; and 4) central and peripheral arterial stiffness. In conjunction with specific goals of the AREA program, comprehensive research experience will be made available to talented undergraduate students who will serve as assistants. To accomplish these specific aims, the following tests will be performed before, and then after 4, 8, and 12 weeks of structured circuit weight training: 1) with subjects in the seated position, blood pressure will be measured three times from the arm using an automated sphygmomanometer, and the average systolic and diastolic pressures will be recorded; 2) with subjects in the supine position, muscle sympathetic nerve activity will be measured directly using the microneurography technique, and blood will be drawn from an anticubital vein for assessment of plasma catecholamine concentrations; 3) subjects will control their breathing at 15 breaths per minute. R-R intervals will be converted to the frequency domain, and respiratory sinus arrhythmia will be assessed as the integrated area under the respiratory frequency band of the power spectrum. Spontaneous baroreflex sensitivity will be assessed in both time and frequency domains. Dynamic baroreflex sensitivity will be assessed from R-R interval responses to arterial pressure elevations during release from Valsalva strain; 4) Using bidirectional transcutaneous Doppler ultrasound probes, pulse waves velocities between the left common carotid artery and the left femoral artery, and the left femoral artery and the superior dorsalis pedis artery will be obtained. Pulse wave velocity will be calculated as the distance between measuring sites divided by the change in time intervals. Values attained from the carotid to femoral artery will be taken as an index of central stiffness, while values from the femoral to superior dorsalis pedis artery will be taken as an index of peripheral stiffness. Reversing or controlling prehypertension through non-pharmacological means will decrease future overall health care costs. Promoting physical activity as a lifestyle choice to decrease arterial pressure will decrease the prevalence of cardiovascular disease and stroke, which are the first and third leading causes of death in the United States.
描述(申请者提供):循环负重训练是一种特定类型的阻力训练,它结合了轻重量和短休息间隔,并导致有益的心肺和肌肉骨骼适应。最重要的适应之一似乎是动脉压的降低,特别是对于可能是高血压前期的人。这个项目的总体目标是记录高血压前期年轻人在循环负重训练中调节动脉压和动脉压调节的生理机制。这项拟议的研究将检验以下假设:循环举重训练降低动脉血压、基线交感神经活动和动脉僵硬,并增加副交感心脏控制和心脏迷走神经压力反射敏感性,与运动训练时间成正比。为了验证这些假说,我们将针对以下具体目标进行研究:1)静息动脉压;2)交感神经活动;3)呼吸性窦性心律失常和心迷走神经压力反射敏感性;4)中枢和外周动脉僵硬。结合该地区计划的具体目标,将为有才华的本科生提供全面的研究经验,他们将担任助理。为了实现这些特定的目标,在进行4周、8周和12周的结构性循环举重训练之前,将进行下列测试:1)对于坐姿的受试者,将使用自动血压计从手臂测量血压三次,并记录平均收缩压和舒张压;2)对于仰卧位的受试者,将使用显微神经学技术直接测量肌交感神经活动,并从反肘部静脉抽血以评估血浆儿茶酚胺浓度;3)受试者的呼吸将控制在每分钟15次。将R-R间期转换到频域,将呼吸性窦性心律失常评估为功率谱呼吸频段下的积分区域。自发性压力感受性反射敏感性将在时间域和频率域进行评估。动态压力感受性反射敏感性将通过释放Valsalva品系期间R-R间期对动脉压升高的反应来评估;4)使用双向经皮多普勒超声探头,将获得左颈总动脉和左股动脉以及左股动脉和足背上动脉之间的脉搏波速度。脉搏波速度将被计算为测量点之间的距离除以时间间隔的变化。颈动脉至股动脉的数值将作为中心硬度的指数,而股动脉至足背上动脉的数值将被用作外周硬度的指数。通过非药物手段逆转或控制高血压前期将降低未来的整体医疗成本。促进体育锻炼作为降低动脉血压的生活方式选择,将降低心血管疾病和中风的患病率,这两种疾病在美国分别是第一和第三大死亡原因。

项目成果

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WILLIAM H COOKE其他文献

WILLIAM H COOKE的其他文献

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{{ truncateString('WILLIAM H COOKE', 18)}}的其他基金

Gender and Orthostatic Tolerance
性别和直立耐受性
  • 批准号:
    6354448
  • 财政年份:
    2001
  • 资助金额:
    $ 21.23万
  • 项目类别:

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