Dendritic integration in multi-tufted mitral cells

多簇二尖瓣细胞中的树突整合

• 批准号: 7277657
• 负责人: JASON B CASTRO
• 金额: $ 2.29万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7277657
• 关键词: Accessory Olfactory Bulbs; Accounting; Acoustics; Action Potentials; Address; Adenylate Cyclase; Affect; Afferent Neurons; Antigen-Presenting Cells; Architecture; Area; Award; Behavior; Behavioral; Behavioral Assay; Biological Assay; Brain; Calcium; Calcium Spikes; Cell physiology; Cells; Cellular biology; Chemicals; Chemosensitization; Chromosome Pairing; Clinical; Cognitive Science; Collaborations; Computer information processing; Condition; Confusion; Data; Dendrites; Detection; Discrimination; Disease; Drug usage; Educational process of instructing; Epithelium; Event; Excitatory Postsynaptic Potentials; Fellowship; Figs - dietary; Fire - disasters; Forskolin; German population; Goals; Hearing; Hippocampal Mossy Fibers; Human; Image; In Vitro; Individual; Inferior Colliculus; Inhibitory Synapse; Institution; Instruction; Kinetics; Knowledge; Laboratories; Lead; Left; Location; Measures; Minor; Modeling; Modification; Molecular; Morphology; Motivation; Mus; Names; Natural regeneration; Nerve; Nerve Crush; Neuromuscular Junction; Neurons; Neurosciences; Noise; Olfactory Epithelium; Optics; Outcome; Output; Pathway interactions; Pattern; Peripheral; Pheromone; Physiological; Preparation; Presbycusis; Process; Property; Protocols documentation; Publications; Published Comment; Publishing; Ramp; Rana; Rate; Recovery; Recurrence; Reflex action; Relative (related person); Reporter; Research; Research Training; Role; Rotation; Sensory; Slice; Societies; Source; Speech; Speed; Stimulus; Structure; Students; Suggestion; Supercomputing; Synapses; System; Techniques; Testing; Time; Transgenic Mice; Trees; Universities; Week; Whole-Cell Recordings; Work; abstracting; age related; base; design; experience; extracellular; granule cell; improved; in vivo; insight; interest; journal article; large-conductance calcium-activated potassium channels; mathematical model; mossy fiber; mouse model; neurotransmitter release; novel; olfactory bulb; posters; presynaptic; prevent; progesterone 11-hemisuccinate-(2-iodohistamine); receptor; research study; response; sex; simulation; social; spatial integration; success; symposium; therapeutic target; vomeronasal organ

DESCRIPTION (provided by candidate): The overall goal of this project is to understand how multitufted mitral cells of the accessory olfactory bulb (AOB) generate selective outputs for only specific combinations of strain and sex. Although receptor properties certainly contribute to mitral cell selectivity, the ability of any neuron to recognize and respond to certain combinations of features depends fundamentally on dendritic integration. Toward this end, we will investigate temporal and spatial integration properties in AOB mitral cells using a combination of in vitro whole cell physiology and calcium imaging. This will contribute to our knowledge of the computational mechanisms and strategies that neurons use to generate responses that are selective for specific activity patterns. By deepening our understanding of how sensory neurons process information and represent the world, we may ultimately be able to identify therapeutic targets for diseases that affect peripheral processing in the chemical senses, as well as others.

描述(由Candiate提供)：本项目的总体目标是了解副嗅球(AOB)的多簇二尖瓣细胞如何仅为特定的品系和性别组合产生选择性输出。尽管受体的特性肯定有助于二尖瓣细胞的选择性，但任何神经元识别和响应某些特征组合的能力基本上取决于树突的整合。为此，我们将结合体外全细胞生理学和钙成像来研究AOB二尖瓣细胞的时间和空间整合特性。这将有助于我们了解神经元用来产生对特定活动模式具有选择性的反应的计算机制和策略。通过加深对感觉神经元如何处理信息和代表世界的理解，我们最终可能能够确定影响化学感觉外周处理的疾病的治疗靶点，以及其他疾病。