Individual Differences in Sensitization to Amphetamine

描述（由申请人提供）： 这项工作的总体目标是调查在个体差异的背景下，安非他明的行为敏化的神经生物学基础。我们的目的是了解心理社会压力和发展的行为敏感安非他明在个体差异的背景下之间的相互作用。行为致敏与药物成瘾有关，因为据认为，可能导致对精神兴奋剂致敏的神经生物学变化可能与可能导致滥用药物成瘾的变化相同，或至少重叠。此外，人们认为，压力和糖皮质激素，特别是可能介导的行为敏化以及吸毒行为的某些方面。我们将研究多巴胺和压力回路中的基因和蛋白质变化如何介导某些个体对精神兴奋剂敏感的倾向。我们将使用这种个体差异的模型来帮助理解一些人如何以及为什么更容易受到滥用药物的影响。

DESCRIPTION (provided by applicant): The overall aim of this work is to investigate the neurobiological basis of behavioral sensitization to amphetamine in the context of individual differences. We aim to understand the interplay between psychosocial stress and the development of behavioral sensitization to amphetamine in the context of individual differences. Behavioral sensitization is relevant to drug addiction as it is thought that the neurobiological changes that may underlie sensitization to psychostimulants may be the same, or at least overlap with, changes that may cause addiction to drugs of abuse. Furthermore, it is thought that stress and glucocorticoids in particular, may mediate some aspects of behavioral sensitization as well as drug taking behaviors. We will examine how gene and protein changes in the dopamine and stress circuitry may mediate the propensity of some individuals to become sensitized to psychostimulants. We will use this model of individual differences to help understand how and why some individuals are more prone to the effects of drugs of abuse.