Minority Predoctoral Fellowship Program

少数族裔博士前奖学金计划

• 批准号: 7152869
• 负责人: Justin Thomas Baca
• 金额: $ 3.75万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7152869
• 关键词: Admission activity; Affinity; Albumins; Binding; Biochemical; Biological Assay; Biological Markers; Blood; Blood Proteins; Blood specimen; Cardiac; Cardiovascular Diseases; Cause of Death; Cessation of life; Chest Pain; Clinical; Clinical Chemistry; Cobalt; Development; Dialysis procedure; Disease; Electrocardiogram; Enzymes; Event; Fellowship; Fellowship Program; Hospitals; Hour; Human; Hydrogels; In Vitro; Individual; Ions; Ischemia; Laboratories; Ligands; Light; Methods; Minority; Monitor; Myocardial Ischemia; Optics; Oxyquinoline; Patients; Phase; Physical Dialysis; Physicians; Plasma; Polymers; Predictive Value; Range; Recording of previous events; Reporting; Research; Serum; Serum Albumin; Structure; Swelling; Testing; United States; Validation; Vertebral column; Visible Radiation; acute coronary syndrome; base; clinical application; clinically relevant; cost; detector; functional group; novel; particle; point of care; pre-doctoral; prevent; rapid diagnosis; response; sensor; small molecule

Rapid diagnosis and continuous monitoring of disease states is currently limited by the need to access a major clinical chemistry laboratory. Polymerized Crystalline Colloidal Arrays (PCCAs) developed in the Asher group have the potential to serve as optical detectors of a wide variety of clinically important analytes. PCCAs are hydrogels that Bragg diffract visible light due to the highly ordered structure of their colloidal particles. Swelling of the hydrogel causes a redshift of the diffracted light. By functionalizing the polymer backbone of the hydrogel with enzymes and small molecule ligands, swelling can be induced in response to the presence of a variety of clinically relevant analytes. This PCCA sensing motif will be developed to detect molecular markers of cardiac ischemia. These sensors will be optimized for point of care applications for situations in which a clinical chemistry lab is not available or expedient. The research will involve the synthesis and characterization of novel polymeric materials, as well as validation of their utility as clinical sensors. The proposed development of PCCAs for clinical applications will combine fundamental materials studies and optimization studies with in vitro trials.

目前，疾病状态的快速诊断和持续监测受到以下需求的限制 访问大型临床化学实验室。聚晶胶体阵列(PCCAs) Asher组有可能作为多种临床重要疾病的光学探测器 分析物。PCCA是一种水凝胶，由于其高度有序的结构，布拉格衍射可见光 胶体颗粒。水凝胶的膨胀导致衍射光的红移。通过将 聚合物的主干水凝胶带有酶和小分子配体，可诱导溶胀 对各种临床相关分析物的反应。这个PCCA感官主题将是 开发用于检测心肌缺血的分子标志物。这些传感器将针对 在临床化学实验室不可用或不适宜的情况下，请注意应用程序。这项研究 将涉及新型聚合物材料的合成和表征，以及它们的验证 可作为临床传感器使用。拟议的临床应用PCCA的开发将结合 基础材料研究和体外试验优化研究。