REGULATION OF VIRUS-INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
基本信息
- 批准号:7160547
- 负责人:
- 金额:$ 23.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-01-01 至 2008-12-31
- 项目状态:已结题
- 来源:
- 关键词:Animal ModelAnimalsApoptosisApoptosis InhibitorApoptoticBaculovirusesBiochemistryCaspaseCell CommunicationCell DeathCellsCellular biologyCessation of lifeDevelopmentDiseaseDominant-Negative MutationDrosophila melanogasterEndopeptidasesFamilyGeneticGoalsHomeostasisHumanHybridsImmunologic Deficiency SyndromesInsectaInterventionInvertebratesKnowledgeMediatingMolecularMolecular AnalysisNeurodegenerative DisordersOncogenicOrganismPathway interactionsPeptide HydrolasesProcessProteinsRegulationResistanceSignal TransductionSystemTherapeuticTissuesViralViral PathogenesisViral ProteinsVirusVirus DiseasesVirus Replicationcell growth regulationin vivoinhibitor/antagonistinsightnovelnovel therapeuticspathogenresearch studytumorigenesisvirus host interaction
项目摘要
Programmed cell death, or apoptosis, is a built-in, signal-induced process by which a cell self-destructs. It is a highly
regulated mechanism that is critical for normal development, tissue homeostasis, and the elimination of pathogen-
infected cells. In humans, misregulated programmed cell death is associated with tumorigenesis, neurodegenerative
diseases, immunodeficiency, and viral pathogenesis. Although many evolutionarily conserved components of the cell
death pathway have been identified, the molecular mechanisms involved in cellular regulation of apoptosis are still
largely unknown. Since host cell apoptosis can limit virus multiplication, many viruses have evolved diverse strategies
to regulate the cell death pathway. The proteins that mediate such viral intervention have provided key insight into the
cell death program. The long term objective of this proposal is to define the molecular mechanisms by which apoptosis
is regulated through the study of three baculovirus-encoded apoptotic regulators: P35, P49, and IAP. Our approach
focuses on the use of baculovirus-infected insect cells as a powerful yet convenient system for molecular analysis of
both the induction and suppression of apoptosis. Building on recent advances in the apoptosis field, we use integrated
approaches in biochemistry, genetics, and cell biology to determine the molecular mechanism of P49 and IAP anti-
apoptotic activity. We focus on P49's novel ability to inhibit an initiator caspase resistant to the pancaspase inhibitor
P35 by defining the molecular determinants of caspase selectivity by both irreversible inhibitors. Utilizing the recently
discovered capacity of baculoviruses to efficiently deliver apoptotic regulators to cultured Drosophila melanogaster
cells, we identify the in vivo targets of P49 and P35 and define the caspase cascade in this model organism. We
determine the molecular mechanism of virus IAP anti-apoptotic activity by characterizing the interactions between
hybrid IAPs and cellular apoptotic effectors. In concert, we also investigate the functional significance of
oligomerization for both viral and cellular IAPs by using novel dominant negative inhibitors. Collectively, these
studies are expected to provide new and fundamental information on virus-host interactions and the regulation of
programmed cell death in animals. Such knowledge will contribute to the development of therapeutic strategies for
apoptosis-associated diseases.
程序性细胞死亡,或细胞凋亡,是一个内在的、信号诱导的细胞自我毁灭的过程。这是一个高度
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
PAUL D FRIESEN其他文献
PAUL D FRIESEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('PAUL D FRIESEN', 18)}}的其他基金
REGULATION OF VIRUS-INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
- 批准号:
7061620 - 财政年份:1997
- 资助金额:
$ 23.88万 - 项目类别:
REGULATION OF VIRUS INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
- 批准号:
6341661 - 财政年份:1997
- 资助金额:
$ 23.88万 - 项目类别:
REGULATION OF VIRUS-INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
- 批准号:
6835707 - 财政年份:1997
- 资助金额:
$ 23.88万 - 项目类别:
REGULATION OF VIRUS INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
- 批准号:
2856049 - 财政年份:1997
- 资助金额:
$ 23.88万 - 项目类别:
REGULATION OF VIRUS INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
- 批准号:
2005060 - 财政年份:1997
- 资助金额:
$ 23.88万 - 项目类别:
REGULATION OF VIRUS INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
- 批准号:
2633575 - 财政年份:1997
- 资助金额:
$ 23.88万 - 项目类别:
REGULATION OF VIRUS-INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
- 批准号:
6694058 - 财政年份:1997
- 资助金额:
$ 23.88万 - 项目类别:
REGULATION OF VIRUS INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
- 批准号:
6137202 - 财政年份:1997
- 资助金额:
$ 23.88万 - 项目类别:
REGULATION OF VIRUS-INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
- 批准号:
8125671 - 财政年份:1997
- 资助金额:
$ 23.88万 - 项目类别:
REGULATION OF VIRUS-INDUCED PROGRAMMED CELL DEATH
病毒诱导的程序性细胞死亡的调节
- 批准号:
6572521 - 财政年份:1997
- 资助金额:
$ 23.88万 - 项目类别:
相似海外基金
The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
- 批准号:
EP/Z000920/1 - 财政年份:2025
- 资助金额:
$ 23.88万 - 项目类别:
Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
- 批准号:
FT230100276 - 财政年份:2024
- 资助金额:
$ 23.88万 - 项目类别:
ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
- 批准号:
MR/X024261/1 - 财政年份:2024
- 资助金额:
$ 23.88万 - 项目类别:
Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
- 批准号:
DE240100388 - 财政年份:2024
- 资助金额:
$ 23.88万 - 项目类别:
Discovery Early Career Researcher Award
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
- 批准号:
2232190 - 财政年份:2023
- 资助金额:
$ 23.88万 - 项目类别:
Continuing Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
- 批准号:
2337595 - 财政年份:2023
- 资助金额:
$ 23.88万 - 项目类别:
Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
- 批准号:
23K17514 - 财政年份:2023
- 资助金额:
$ 23.88万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Analysis of thermoregulatory mechanisms by the CNS using model animals of female-dominant infectious hypothermia
使用雌性传染性低体温模型动物分析中枢神经系统的体温调节机制
- 批准号:
23KK0126 - 财政年份:2023
- 资助金额:
$ 23.88万 - 项目类别:
Fund for the Promotion of Joint International Research (International Collaborative Research)
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
- 批准号:
2842926 - 财政年份:2023
- 资助金额:
$ 23.88万 - 项目类别:
Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
- 批准号:
NC/X001644/1 - 财政年份:2023
- 资助金额:
$ 23.88万 - 项目类别:
Training Grant














{{item.name}}会员




