Combining Cell Lineages for Enhanced Joint Tissue Regeneration

组合细胞谱系以增强关节组织再生

• 批准号: 100557
• 金额: $ 77.17万
• 依托单位: TIGENIX LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=100557
• 关键词: Combining; Cell; Lineages; Enhanced; Joint

This project was aimed at establishing proof of concept in orthopaedic applications of a novel, three-dimensional co-culture technology based on the use of a tissue-specific, three-dimensional biomaterials scaffold technology in combination with biologics. This platform is based on the culture of mesenchymal stem cells (MSCs) concurrently with autologous monocytes in matrices. The technique holds strong potential to enhance, in a cost-effective manner, the number and tissue-specific activity of MSCs available for treatment and the ability to deliver these treatments to specific sites in a minimally invasive manner. The remit of this project was to conduct lab-based in-vitro studes to develop and optimise the platform for a broad range of orthopaedic applications. The results were tested subsequently to establish proof of concept by applying the platform to in vivo models for the repair of articular cartilage.

该项目旨在建立一种新型三维共培养技术在骨科应用中的概念验证，该技术基于组织特异性三维生物材料支架技术与生物制剂的结合使用。该平台基于间充质干细胞（MSC）与基质中的自体单核细胞的同时培养。该技术具有很强的潜力，以具有成本效益的方式提高可用于治疗的MSC的数量和组织特异性活性，以及以微创方式将这些治疗递送到特定部位的能力。该项目的职责是进行基于实验室的体外研究，以开发和优化广泛骨科应用的平台。随后对结果进行了测试，以通过将平台应用于关节软骨修复的体内模型来建立概念验证。