Emotional Acceptance Behavior Therapy for Anorexia Nervosa

神经性厌食症的情绪接受行为疗法

• 批准号: 7424161
• 负责人: MARSHA D MARCUS
• 金额: $ 22.28万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-28 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7424161
• 关键词: Acute; Adherence; Adolescence; Adolescent; Adult; Aftercare; Age; Anorexia Nervosa; Awareness; Behavior; Behavior Therapy; Behavioral; Body Weight; Body mass index; Caring; Client satisfaction; Clinical Management; Clinical Treatment; Cognitive Therapy; Coupled; Crows; Data; Development; Drops; Eating; Eating Disorders; Emotional; Enrollment; Feedback; Funding; Future; Goals; Individual; Inpatients; Insurance; Intervention; Investigation; Lead; Length of Stay; Location; Manuals; Measures; Monitor; Morbidity - disease rate; Outpatients; Participant; Patients; Phase; Pilot Projects; Psychopathology; Public Health; Publishing; Quality of life; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Rate; Recruitment Activity; Relapse; Relative (related person); Reporting; Research; Research Personnel; Risk; Role; Services; Shapes; Short-Term Course; Standards of Weights and Measures; Structure; Symptoms; Techniques; Testing; Treatment Protocols; Underweight; United States; Weight; Work; base; design; follow-up; innovation; mortality; negative emotional state; novel; nutrition; prescription document; prescription procedure; programs; response; restoration; satisfaction; severe mental illness; theories; therapy adherence; therapy development; week trial

DESCRIPTION (provided by applicant): Anorexia nervosa (AN) is a serious mental illness characterized by significant morbidity and mortality. Yet, there is little evidence to guide treatment, particularly for older adolescents and adults, who comprise the majority of patients. Thus the overall objective of the work described in this application is to develop and evaluate the preliminary efficacy of a new psychotherapeutic intervention for older adolescents and adults with AN. Emotional Acceptance Behavior Therapy (EABT) for AN is based on a research informed conceptualization of AN that emphasizes the role of anorexic behaviors in helping patients avoid negative emotional states that are perceived as overwhelming and intolerable. The intervention incorporates behavioral principles to promote restoration of adequate nutrition and an acceptable body weight, and strategies to increase emotional awareness and reduce the emotional avoidance that perpetuates AN. Two phases of treatment development are proposed. First, the investigators will draft a treatment manual and adherence measure, and pre-test the intervention with 6-8 patients. In the second phase, the preliminary efficacy of EABT will be evaluated by treating 30 AN patients age > 17 years in an open 22 week trial. Participants will be assessed at baseline, post-treatment and 3- and 6- months after treatment. It is hypothesized that EABT will be associated acceptable rates of client satisfaction and treatment attrition, and improvements in eating disorder symptoms, other psychiatric symptoms, emotional avoidance, and quality of life at post-treatment. It also is hypothesized that EABT will be associated with improvements in eating disorder symptoms, other psychiatric symptoms, emotional avoidance, and quality of life at 3- and 6-month post- treatment follow-up. If hypotheses are confirmed, the investigators will propose a full-scale randomized controlled trial of EABT in a subsequent application. The proposed work is significant as an effort to develop and systematically evaluate the acceptability and preliminary efficacy of a novel, theory-driven outpatient psychotherapeutic intervention for older adolescents and adults with AN. Findings may lead to an efficacious treatment for AN, a critical public health problem.

描述（由申请人提供）：神经性厌食症（AN）是一种严重的精神疾病，其特征是显著的发病率和死亡率。然而，很少有证据可以指导治疗，特别是对于年龄较大的青少年和成年人，他们构成了大多数患者。因此，在本申请中描述的工作的总体目标是开发和评估一种新的心理治疗干预对患有AN的大龄青少年和成人的初步疗效。AN的情绪接受行为疗法（EABT）是基于AN的研究信息概念化，强调情绪行为在帮助患者避免被认为是压倒性和不可忍受的负面情绪状态中的作用。干预措施包括行为原则，以促进恢复足够的营养和可接受的体重，以及提高情绪意识和减少使AN永久化的情绪回避的策略。提出了两个阶段的治疗发展。首先，研究人员将起草一份治疗手册和依从性措施，并对6-8名患者进行预测试。在第二阶段，EABT的初步疗效将通过在开放的22周试验中治疗30名年龄> 17岁的AN患者来评估。将在基线、治疗后以及治疗后3个月和6个月对受试者进行评估。据推测，EABT将与可接受的客户满意度和治疗损耗率，以及治疗后进食障碍症状，其他精神症状，情绪回避和生活质量的改善相关。还假设EABT将与治疗后3个月和6个月随访时进食障碍症状、其他精神症状、情绪回避和生活质量的改善相关。如果假设得到证实，研究者将在随后的申请中提出一项EABT的全面随机对照试验。拟议的工作是显着的努力，开发和系统地评估的可接受性和初步疗效的一种新的，理论驱动的门诊心理治疗干预的年龄较大的青少年和成人与AN。研究结果可能会导致一个有效的治疗AN，一个关键的公共卫生问题。