Genome-Wide Association Study of Schizophrenia

精神分裂症的全基因组关联研究

• 批准号: 7343098
• 负责人: Pablo V. Gejman
• 金额: $ 13.99万
• 依托单位: NORTHSHORE UNIVERSITY HEALTHSYSTEM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-27 至 2008-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7343098
• 关键词: Accounting; Admixture; African American; American; Biological; Biometry; Candidate Disease Gene; Clinical; Clinical Data; DNA; DNA Resequencing; Data; Data Set; Database Management Systems; European; Evaluation; Functional disorder; Funding; Genetic; Genome; Genotype; Goals; Grant; Individual; Information Networks; Maps; Molecular Genetics; National Institute of Mental Health; Policies; Population; Protocols documentation; Rate; Sampling; Schizophrenia; Scientist; Single Nucleotide Polymorphism Map; Site; Specimen; Standards of Weights and Measures; Susceptibility Gene; Test Result; Testing; base; case control; clinical Diagnosis; genetic association; genetic linkage analysis; genome wide association study; programs; repository; research study; trait

DESCRIPTION (provided by applicant): This is an application for 1 year of funding for an R01 site submitted under RFA-MH-07-060, "Limited Competition for Applications to Analyze Whole Genome Association Data for NIMH (R01)." The rationale underlying this proposal is that since the pathophysiology of SZ is unknown, but is likely to involve multiple genetic components, application of the genome-wide association strategy to clinical samples with adequate statistical power is expected to identify susceptibility genes that have been missed by linkage analysis and by candidate gene association studies. The Specific aims are: 1) Genotype a genome-wide SNP map in 1,540 cases and 1,540 screened control subjects of European ancestry (EA), and 1,100 African American (AA) cases and 1,100 AA controls from the repository-based Molecular Genetics of Schizophrenia (MGS) sample collected by ten sites under a common protocol with demonstrated inter-rater reliability for diagnosis and clinical ratings. 2) Carry out primary and secondary analyses of genetic association of the trait, accounting for population substructure and admixture. 3) In concordance with Genetic Association Information Network (GAIN) policies, we will rapidly share the genotypic data and a large phenotypic dataset. All DNA specimens and clinical data for cases and controls are already available for the GAIN experiments and are being made publicly available by the NIMH repository program (www.nimhqenetics.org)using its standard centralized database management system, so that other scientists will be able to use these specimens and clinical data to check, confirm, and extend our findings. The overall goal of this application is to find new susceptibility genes for schizophrenia.

描述（由申请人提供）：这是根据RFA-MH-07-060提交的R01网站1年资金的申请，“申请的竞争有限，以分析NIMH（R01）的整个基因组协会数据。”该提案的基本原理是，由于SZ的病理生理学尚不清楚，但可能涉及多个遗传成分，因此全基因组关联策略的应用到具有足够统计能力的临床样本中，预计将识别出因连锁分析而遗漏的易感基因，并由候选基因协会研究所遗漏。具体目的是：1）基因型全基因组全基因组的SNP图和1,540例欧洲祖先（EA）的筛选对照受试者（EA）和1,100个非洲裔美国人（AA）病例（AA）病例（AA）病例（AA）病例，1,100例AA对照，以及基于Reposority contectial contersion contery croment coldistion conforsion Seriagion contersision（MGS）的基于Reposority的对照组，该案例（MGS）的临床依次是，该临床依次依次介绍了精神疾病（MGS），评分。 2）进行性状遗传关联的主要和次要分析，考虑了种群子结构和混合。 3）与遗传关联信息网络（增益）策略一致，我们将迅速共享基因型数据和大型表型数据集。所有DNA标本和病例和对照的临床数据都已用于增益实验，并使用其标准的集中数据库管理系统可以通过NIMH存储库计划（www.nimhqenetics.org）公开获得，以便其他科学家能够使用这些标本和临床数据来检查，并确认，并扩展了我们的发现。该应用的总体目标是找到精神分裂症的新易感基因。