权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Integrating HIV Prevention into Clinical Care for PLWHA in South Africa

将艾滋病毒预防纳入南非艾滋病毒感染者的临床护理

基本信息

批准号：
7228387
负责人：
JEFFREY D FISHER
金额：
$ 104.85万
依托单位：
UNIVERSITY OF CONNECTICUT STORRS
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-11 至 2011-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7228387
关键词：
AIDS prevention AIDS/HIV problem Abate Adherence Affect African Age Anti-Retroviral Agents Behavior Behavioral Caring Case Study Centers for Disease Control and Prevention (U.S.)Clinic Clinical Condition Control Groups Counseling Country Data Development Disease Disease Progression Drug usage Effectiveness Effectiveness of Interventions Environment Epidemic Evaluation Funding Goals Government HIV Health Health Personnel Healthcare Human Human Resources Human immunodeficiency virus test Incentives Incidence Individual Injection of therapeutic agent International International Agencies Intervention Intervention Studies Investigation Learning Life Link Mediating Medical Surveillance Modeling Monitor Motivation Natural History Numbers Outcome Study Outcomes Research Participant Patients Persons Pharmaceutical Preparations Population Prevalence Prevention Prevention approach Prevention intervention Preventive Primary Health Care Private Sector Professional counselor Protocols documentation Public Health Randomized Controlled Trials Rate Recommendation Reporting Research Research Design Research Personnel Research Support Risk Risk Behaviors Risk Reduction Services Sex Behavior Site Societies Source South Africa Specific qualifier value Standards of Weights and Measures Stigmata Suggestion System Techniques Testing Time Treatment Protocols United States National Institutes of Health Virus Work World Health Organization antiretroviral therapy base behavior change cohort design early /brief intervention /therapy improved inner city motivational enhancement therapy pathogen patient oriented prevent prevention service programs skills social stigma stem transmission process uptake

项目摘要

DESCRIPTION (provided by applicant): Project Summary: The South African HIV epidemic continues to cause catastrophic human suffering across all sectors of society. With the rollout of antiretroviral therapy, however, far more South Africans are being tested for HIV and far more are entering HIV clinical care. The proposed research involves development, implementation, and evaluation of a culturally-appropriate HIV prevention intervention, situated in the South African HIV clinical care context, and aimed at assisting South African PLWHA to reduce HIV transmission risk behavior. This intervention approach is based on the behavior change framework from the Options Project; an acceptable, feasible, and effective HIV prevention intervention, implemented in US HIV care settings, which significantly reduced HIV+ individuals' HIV transmission risk behavior. The overall objective of the proposed research is to create a culturally-appropriate, effective, and efficient intervention strategy that may be widely disseminated within the South African clinical care context, to aid in stemming the South African HIV epidemic. The proposed research design involves a cluster randomized controlled trial of the effectiveness of a counselor-driven HIV prevention intervention, delivered in the South African clinical care context, compared to a standard-of-care control, in reducing HIV transmission risk behavior and incident STI rates among South African PLWHA. Specific aims of the proposed investigation are to conduct formative research with South African PLWHA and South African HIV care personnel, to identify unique obstacles to HIV preventive behavior for South African PLWHA, and to identify ways of overcoming these obstacles, in a feasible and culturally-acceptable, clinical care-based intervention; to design, pilot test, refine, implement, and evaluate an intervention, to be delivered in the South African HIV care setting, to assist South African PLWHA to reduce HIV transmission risk behaviors and incident STI; and to utilize the standard of care control as a cohort for a longitudinal natural history study of HIV transmission risk behavior, STI incidence, and how health improvements associated with ARV treatment may be related to changes in HIV risk behavior among South African PLWHA. Relevance. The proposed research aims to develop an effective and readily disseminated intervention to improve individual and public health by preventing transmission of HIV to uninfected individuals, and acquisition of STI by HIV+ persons, in the context of the South African HIV epidemic.

项目简介：南非艾滋病疫情继续给社会各阶层造成灾难性的人类痛苦。然而，随着抗逆转录病毒疗法的推出，更多的南非人正在接受艾滋病毒检测，更多的人正在接受艾滋病毒临床护理。拟议的研究涉及开发，实施和评估文化上适当的艾滋病毒预防干预措施，位于南非艾滋病毒临床护理背景下，旨在协助南非PLWHA减少艾滋病毒传播风险行为。这种干预方法基于选项项目的行为改变框架;在美国艾滋病护理环境中实施的可接受、可行和有效的艾滋病预防干预措施，显著降低了HIV+个体的HIV传播风险行为。拟议研究的总体目标是建立一个文化上适当的，有效的，高效的干预策略，可以在南非的临床护理范围内广泛传播，以帮助遏制南非艾滋病毒的流行。拟议的研究设计涉及一个集群随机对照试验的有效性顾问驱动的艾滋病毒预防干预措施，提供在南非的临床护理背景下，相比标准的护理控制，在减少艾滋病毒传播的风险行为和事件性传播感染率之间的南非PLWHA。拟议调查的具体目标是与南非艾滋病毒感染者和艾滋病毒护理人员进行形成性研究，以确定南非艾滋病毒感染者预防艾滋病毒行为的独特障碍，并确定克服这些障碍的方法，以可行和文化上可接受的临床护理为基础的干预措施;设计、试点测试、完善、实施和评估将在南非艾滋病毒护理环境中实施的干预措施，以帮助南非艾滋病毒感染者/艾滋病患者减少艾滋病毒传播风险行为和性传播感染事件;并利用护理控制标准作为一个队列的纵向自然史研究艾滋病毒传播的风险行为，性传播感染的发病率，以及如何与抗逆转录病毒治疗相关的健康改善可能与南非艾滋病毒感染者艾滋病风险行为的变化。本案无关拟议的研究旨在开发一种有效和易于传播的干预措施，以改善个人和公共健康，防止艾滋病毒传播给未感染的个人，艾滋病毒+的人获得性传播感染，在南非艾滋病毒流行的背景下。