权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Integrating HIV Prevention into Clinical Care for PLWHA in South Africa

将艾滋病毒预防纳入南非艾滋病毒感染者的临床护理

基本信息

批准号：
8124450
负责人：
JEFFREY D FISHER
金额：
$ 48.32万
依托单位：
UNIVERSITY OF CONNECTICUT STORRS
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-11 至 2011-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8124450
关键词：
AIDS prevention AIDS/HIV problem Abate Adherence Affect African Age Anti-Retroviral Agents Behavior Behavioral Caring Case Study Centers for Disease Control and Prevention (U.S.)Clinic Control Groups Counseling Country Data Development Disease Disease Progression Drug usage Effectiveness Environment Epidemic Evaluation Funding Goals Government HIV Health Health Personnel Healthcare Human Human Resources Human immunodeficiency virus test Incentives Incidence Individual Injection of therapeutic agent International International Agencies Intervention Intervention Studies Investigation Learning Life Link Mediating Modeling Monitor Motivation Natural History Outcome Study Outcomes Research Participant Patients Persons Pharmaceutical Preparations Population Prevalence Prevention Prevention approach Preventive Preventive Intervention Primary Health Care Private Sector Professional counselor Protocols documentation Public Health Randomized Controlled Trials Recommendation Regimen Reporting Research Research Design Research Personnel Research Support Risk Risk Behaviors Risk Reduction Services Sex Behavior Site Societies Source South Africa Specific qualifier value Stigmata Suggestion System Techniques Testing Time United States National Institutes of Health Virus Work antiretroviral therapy base behavior change brief intervention clinical care cohort design effective intervention group intervention improved inner city intervention effect motivational enhancement therapy pathogen patient oriented prevent prevention service programs sex risk skills social stigma standard of care stem surveillance data transmission process uptake

项目摘要

DESCRIPTION (provided by applicant): Project Summary: The South African HIV epidemic continues to cause catastrophic human suffering across all sectors of society. With the rollout of antiretroviral therapy, however, far more South Africans are being tested for HIV and far more are entering HIV clinical care. The proposed research involves development, implementation, and evaluation of a culturally-appropriate HIV prevention intervention, situated in the South African HIV clinical care context, and aimed at assisting South African PLWHA to reduce HIV transmission risk behavior. This intervention approach is based on the behavior change framework from the Options Project; an acceptable, feasible, and effective HIV prevention intervention, implemented in US HIV care settings, which significantly reduced HIV+ individuals' HIV transmission risk behavior. The overall objective of the proposed research is to create a culturally-appropriate, effective, and efficient intervention strategy that may be widely disseminated within the South African clinical care context, to aid in stemming the South African HIV epidemic. The proposed research design involves a cluster randomized controlled trial of the effectiveness of a counselor-driven HIV prevention intervention, delivered in the South African clinical care context, compared to a standard-of-care control, in reducing HIV transmission risk behavior and incident STI rates among South African PLWHA. Specific aims of the proposed investigation are to conduct formative research with South African PLWHA and South African HIV care personnel, to identify unique obstacles to HIV preventive behavior for South African PLWHA, and to identify ways of overcoming these obstacles, in a feasible and culturally-acceptable, clinical care-based intervention; to design, pilot test, refine, implement, and evaluate an intervention, to be delivered in the South African HIV care setting, to assist South African PLWHA to reduce HIV transmission risk behaviors and incident STI; and to utilize the standard of care control as a cohort for a longitudinal natural history study of HIV transmission risk behavior, STI incidence, and how health improvements associated with ARV treatment may be related to changes in HIV risk behavior among South African PLWHA. Relevance. The proposed research aims to develop an effective and readily disseminated intervention to improve individual and public health by preventing transmission of HIV to uninfected individuals, and acquisition of STI by HIV+ persons, in the context of the South African HIV epidemic.

描述（由申请人提供）：项目概要：南非艾滋病毒流行继续给社会各阶层带来灾难性的人类痛苦。然而，随着抗逆转录病毒疗法的推出，越来越多的南非人正在接受艾滋病毒检测，越来越多的南非人正在接受艾滋病毒临床护理。拟议的研究涉及在南非艾滋病毒临床护理背景下开发、实施和评估文化上适当的艾滋病毒预防干预措施，旨在帮助南非艾滋病毒感染者减少艾滋病毒传播风险行为。这种干预方法基于选项项目的行为改变框架；在美国艾滋病毒护理机构中实施的一项可接受、可行且有效的艾滋病毒预防干预措施，显着降低了艾滋病毒+个体的艾滋病毒传播风险行为。拟议研究的总体目标是创建一种适合文化的、有效的和高效的干预策略，可以在南非临床护理环境中广泛传播，以帮助遏制南非艾滋病毒的流行。拟议的研究设计涉及一项整群随机对照试验，旨在评估在南非临床护理背景下实施的咨询师驱动的艾滋病毒预防干预措施与标准护理控制相比，在降低南非艾滋病毒感染者中艾滋病毒传播风险行为和性传播感染事件发生率方面的有效性。拟议调查的具体目标是与南非艾滋病毒感染者和南非艾滋病毒护理人员进行形成性研究，以确定南非艾滋病毒感染者艾滋病毒预防行为的独特障碍，并找出克服这些障碍的方法，以可行的、文化上可接受的、基于临床护理的干预措施；设计、试点、完善、实施和评估将在南非艾滋病毒护理环境中实施的干预措施，以协助南非艾滋病毒感染者减少艾滋病毒传播风险行为和性传播感染事件；利用护理控制标准作为队列，对南非艾滋病毒感染者中的艾滋病毒传播风险行为、性传播感染发病率以及与抗逆转录病毒治疗相关的健康改善如何与艾滋病毒风险行为的变化相关进行纵向自然史研究。关联。拟议的研究旨在制定一种有效且易于传播的干预措施，在南非艾滋病毒流行的背景下，通过防止艾滋病毒传播给未感染者以及艾滋病毒阳性者感染性传播感染来改善个人和公共卫生。