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Midcareer Investigator Award in Alcohol-Related Human Disease Research

酒精相关人类疾病研究职业中期研究员奖

基本信息

批准号：
7233687
负责人：
SUZANNE M. DE LA MONTE
金额：
$ 14.89万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-20 至 2011-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7233687
关键词：
1-Phosphatidylinositol 3-Kinase Acetylcholinesterase Adult Adverse effects Alcohol abuse Alcohols Anterior Hypothalamus Apoptosis Arts Astrocytes Atrophic Award Binding Biochemical Brain Cell Death Cell Survival Cells Cerebellar cortex structure Cerebrum Choline O-Acetyltransferase Chronic Clinical Clinical Pathology Cognitive Congenital Abnormality Data Development Dose Down-Regulation Endothelial Cells Energy Metabolism Environment Equilibrium Ethanol Exercise Exhibits Experimental Models Funding Future Genes Goals Growth Hospitals Human Impairment Insulin Insulin Receptor Insulin Resistance Insulin Signaling Pathway Insulin-Like Growth Factor I Junior Physician Laboratories Leadership Link Liver diseases Measures Mediating Medical Students Mentors Mentorship Methodology Microglia Minority Groups Mitochondria Modeling Molecular National Institute on Alcohol Abuse and Alcoholism Nature Neocortex Nerve Degeneration Neuraxis Neuroglia Neurons Neurosciences Oligodendroglia Pathologist Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide Phosphoric Monoester Hydrolases Phosphorylation Phosphotransferases Physicians Population Postdoctoral Fellow Rattus Research Research Personnel Rhode Island Scientist Signal Transduction Somatomedins Structure Students Technology Testing Tissue Sample Training Translational Research Underrepresented Minority United States United States National Institutes of Health Universities Woman Work alcohol exposure career cingulate cortex feeding human PTEN protein human disease human study human tissue indexing insight insulin receptor substrate 1 protein insulin signaling liver function member minority trainee mitochondrial dysfunction motor deficit neurotoxicity problem drinker professor receptor response

项目摘要

DESCRIPTION (provided by applicant): Alcohol abuse is the single most common known and preventable cause of birth defects, and a major contributor to both chronic liver disease and neurodegeneration in the United States. Our research has linked several chronic alcohol exposure-mediated abnormalities in brain and liver function to impairments in insulin and insulin-like growth factor signaling, particularly with regard to cell survival and energy metabolism. However, in order to capitalize on these recent gains, it will be necessary to extend the analyses to human disease states using state-of-the-art methodology. The major goals of this proposal are to: 1) investigate mechanisms of alcohol-mediated neurodegeneration in adult human brains using molecular and biochemical approaches; 2) provide a strong, highly supportive environment to train and mentor junior investigators, particularly physician-scientists, to investigate human disease mechanisms by utilizing current technology to analyze human tissue samples; and 3) educate junior investigators about the importance of experimental models for testing hypotheses and validating results from human studies. Emphasis will be placed on including women and minority trainees. Suzanne M. De la Monte is a Pathologist and Neuropathologist by training and clinical activities at the Rhode Island Hospital, and Professor of Pathology and Clinical Neuroscience at Brown University. Dr. De la Monte has a long track record of training young investigators in human disease, biomedical, and translational research. Her laboratory, which currently is supported by NIH funding from NIAAA, hosts several trainees including undergraduates, medical students, graduate students, postdoctoral fellows, and junior physician-scientists, most of whom are women or members of under-represented minority groups. This Mid-career investigator award will provide better opportunity for Dr. De la Monte to exercise leadership and high quality mentorship and training of promising young scientists. The information included in this application demonstrates a productive career in human and translational research, and demonstrates Dr. De la Monte's commitment to continuing this type of work while mentoring scientists for the future.

描述(由申请人提供)：酒精滥用是导致出生缺陷的最常见和最可预防的单一原因，也是美国慢性肝病和神经退行性变的主要原因。我们的研究将几种慢性酒精暴露导致的大脑和肝功能异常与胰岛素和胰岛素样生长因子信号的损害联系在一起，特别是在细胞存活和能量代谢方面。然而，为了利用这些最近的成果，有必要使用最先进的方法将分析扩展到人类疾病状态。这项建议的主要目标是：1)使用分子和生物化学方法研究酒精在成人大脑中介导的神经退行性变的机制；2)提供一个强有力的、高度支持的环境，以培训和指导初级研究人员，特别是内科科学家，通过利用现有技术分析人体组织样本来研究人类疾病的机制；以及3)教育初级研究人员关于用于验证假设和验证人体研究结果的实验模型。重点将包括妇女和少数族裔受训人员。苏珊娜·德拉蒙特是罗德岛医院的病理学家和神经病理学家，在罗德岛医院接受培训并从事临床活动，同时也是布朗大学的病理学和临床神经科学教授。德拉蒙特博士在对年轻研究人员进行人类疾病、生物医学和转化研究方面的培训方面有着长期的记录。她的实验室目前由NIH由NIAAA提供资金支持，有几名实习生，包括本科生、医学生、研究生、博士后研究员和初级内科科学家，其中大多数是女性或代表不足的少数群体的成员。这一职业生涯中期研究人员奖将为德拉蒙特博士提供更好的机会行使领导力，并为有前途的年轻科学家提供高质量的指导和培训。这份申请中包含的信息表明了他在人类和翻译研究领域富有成效的职业生涯，并表明了德拉蒙特博士在继续这类工作的同时为未来的科学家提供指导的承诺。