Cerebrovascular Physiology of Infants with CHD

先天性心脏病婴儿的脑血管生理学

• 批准号: 7252013
• 负责人: DANIEL Jacques LICHT
• 金额: $ 13.33万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7252013
• 关键词: Acids; Admission activity; Anatomy; Anisotropy; Area; Attention; Blood Vessels; Brain; Brain Diseases; Brain Injuries; Carbon Dioxide; Cardiac; Cardiac Surgery procedures; Cerebrovascular Circulation; Cerebrovascular Physiology; Cerebrum; Childhood; Chronic; Climate; Clinical; Clinical Investigator; Clinical Research; Cognitive; Collaborations; Complex; Condition; Congenital Heart Defects; Critical Care; Data; Dedications; Depth; Development; Diagnosis; Diffuse; Disease; Environment; Goals; Growth; Hemodilution; Hypoplastic Left Heart Syndrome; Imaging technology; Infant; Injury; Intensive Care Units; Invasive; K-Series Research Career Programs; Knowledge; Lesion; Localized; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Metabolic; Metabolism; Methods; Microcephaly; Modification; Morbidity - disease rate; Neonatal; Neurocognitive; Neurology; Newborn Infant; Numbers; Operative Surgical Procedures; Optics; Outcome; Patients; Pattern; Pediatric Hospitals; Perfusion; Periventricular Leukomalacia; Philadelphia; Physiological; Play; Population; Premature Birth; Prematurity of fetus; Procedures; Rate; Relative (related person); Research; Research Personnel; Resolution; Risk; Risk Factors; Role; Safety; Survivors; Techniques; Testing; Transposition of Great Vessels; Ventricular septum; base; blood flow measurement; brain tissue; brain volume; career; cerebral hypoperfusion; cerebrovascular; comparative; improved; infant brain injury; neonate; neuroimaging; novel; point of care; programs; repaired; success; tomography; white matter

DESCRIPTION (provided by applicant): This Career Development Award will support the growth of Dr. Daniel Licht into an independent clinical investigator with specialization in pediatric cerebrovascular injury. Dr. Licht's primary career development goal is to establish a multi-disciplinary research program encompassing the fields of neurology, critical care, and neuroimaging. To achieve these goals, Dr. Licht proposes collaborations between physicists and clinicians to develop new non-invasive methods for measuring cerebral blood flow (CBF) in newborn infants. Through modification and application of new imaging technologies, the proposed research will investigate the role of CBF in acquired brain injury in infants with severe congenital heart defects (CHD). CBF represents an important physiologic parameter for the understanding, diagnosis and management of neonatal brain disorders, and plays a pivotal role in brain injury in infants with severe CHD before heart surgery. In previous studies, Dr. Licht has found that deranged cerebrovascular physiology was associated with pre-operative structural brain injury. To further investigate this association, he proposes to measure and compare global and regional brain volumes in infants with CHD to those without CHD, and determine whether these differences are related to an altered CBF. Dr. Licht will use MRI based techniques to make these measurements and will test diffuse optic tomography (DOT) for comparative measurements. To date, both normative and disease data on pediatric brain perfusion remain sparse due to the lack of suitable techniques for CBF measurement. DOT is complimentary to MRI in that it offers excellent temporal resolution and can be applied at the point of care. Furthermore, DOT offers concurrent analysis of metabolic rate while sacrificing only mild anatomic resolution.

描述（由申请人提供）：该职业发展奖将支持丹尼尔·利希特博士成长为一名专门研究儿科脑血管损伤的独立临床研究者。Licht博士的主要职业发展目标是建立一个涵盖神经病学，重症监护和神经影像学领域的多学科研究计划。为了实现这些目标，Licht博士建议物理学家和临床医生合作开发新的非侵入性方法来测量新生儿的脑血流量（CBF）。通过改进和应用新的成像技术，拟议的研究将探讨CBF在严重先天性心脏病（CHD）婴儿获得性脑损伤中的作用。CBF是了解、诊断和治疗新生儿脑部疾病的重要生理参数，在严重CHD婴儿心脏手术前的脑损伤中起着关键作用。在以前的研究中，Licht博士发现脑血管生理紊乱与术前结构性脑损伤有关。为了进一步研究这种关联，他建议测量和比较患有CHD的婴儿与没有CHD的婴儿的全局和局部脑容量，并确定这些差异是否与CBF改变有关。Licht博士将使用基于MRI的技术进行这些测量，并将测试漫射光学断层扫描（DOT）进行比较测量。迄今为止，由于缺乏合适的CBF测量技术，儿科脑灌注的规范性和疾病数据仍然稀少。DOT是MRI的补充，因为它提供了出色的时间分辨率，可以在护理点应用。此外，DOT提供代谢率的同时分析，同时仅牺牲轻微的解剖分辨率。