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The role of microbial organisms in acute lung injury

微生物在急性肺损伤中的作用

基本信息

批准号：
7213324
负责人：
KEVIN C DOERSCHUG
金额：
$ 12.5万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-04-01 至 2008-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7213324
关键词：
Acute Acute Lung Injury Affect Anti-Inflammatory Agents Anti-inflammatory Antibiotics Area Award Bacteremia Bacterial Pneumonia Bacterial Translocation Biomedical Research Blood Blood specimen Cellular biology Cessation of life Class Clinical Research Code Commit Conflict (Psychology)Culture Techniques DNA Development Development Plans Disease Enrollment Ensure Environment Epidemiology Fostering Functional disorder Fungal DNA Fungemia Gases Goals Human Immune response Incidence Infection Inflammation Inflammatory Inflammatory Response Injury Institution Lead Lung Lung Compliance Master&apos s Degree Measures Mediating Mediator of activation protein Mentors Mentorship Microbe Microbiology Modification Organism Outcome Pancreatitis Pathogenesis Patients Peritonitis Physiology Pneumonia Polymerase Chain Reaction Pulmonology RNA, Ribosomal, 18S Rate Research Research Design Research Personnel Risk Risk Factors Role Scientist Score Sepsis Sepsis Syndrome Severities Specimen Standards of Weights and Measures Stimulus Syndrome Techniques Time Training Transfusion Trauma United States body system career design experience functional status human study improved lung injury microbial microorganism mortality statistics success

项目摘要

This application is to support the development of Dr. Kevin Doerschug so that he will become an accomplished clinician-scientist and independent researcher. Dr. Gary Hunninghake will assume responsibility as mentor to ensure the success of the career development plan. The focus of the proposal is an intensive research experience in studies of human lung injury and sepsis. To achieve this, Dr. Doerschug will continue formal training in the design and analysis of human studies, as well as scientific techniques to analyze specimens from human patients with acute lung injury and sepsis. Dr. Doerschug will complete didactic training in these areas including classes in epidemiology, statistics, cell biology, and microbiology. Dr. Doerschug's classes will culminate in a Master's Degree in Translational Biomedical Research. The research mentorship will involve active development of and participation in studies designed to identify factors involved in the pathogenesis of acute lung injury and sepsis. Specifically, Dr. Doerschug will focus on the role of circulating microorganisms as the stimulus for the inflammation that characterizes these diseases. Initial studies will include identifying bacteremia or fungemia in patients with SIRS (a common risk factor for sepsis and acute lung injury), using PCR to detect previously undetectable organisms. Additionally, Dr. Doerschug will investigate the relationships between circulating microorganisms and the development of acute lung injury, focusing on patient physiology and outcomes. Once completed, these preliminary studies will more accurately describe the relationships between infection and inflammation in these disorders. Further studies can then focus on the modification of host responses to these infections. Throughout Dr. Doerschug's career development, he will interface with trainees in clinical research, pulmonary medicine, and microbiology. This intellectually rich environment will help foster the career development of Dr. Doerschug, providing ample opportunity for critical review throughout the period of this award. Both the mentor and the institution are highly committed to Dr. Doerschug's scientific development and academic success.

这个应用程序是为了支持凯文博士的发展，使他将成为一个