Neurobiology of Insomnia as Measured with FMRI

通过 FMRI 测量失眠的神经生物学

• 批准号: 7491002
• 负责人: HENRY John ORFF
• 金额: $ 2.78万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-27 至 2008-08-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7491002
• 关键词: Area; Behavioral; Bilateral; Brain; Chronic Insomnia; Cognitive; Daily; Disease; Exhibits; Functional Magnetic Resonance Imaging; Future; Impairment; Individual; Inferior; Inferior frontal gyrus; Investigation; Left; Measures; Medical; Memory; Middle frontal gyrus structure; Neurobiology; Neuropsychological Tests; Parietal; Parietal Lobe; Patient Self-Report; Patients; Perception; Performance; Performance at work; Physiology; Prevalence; Primary Insomnia; Quality of life; Questionnaires; Relative (related person); Research; Risk; Severities; Signal Transduction; Sleep Deprivation; Sleep Disorders; Sleeplessness; Symptoms; Testing; United States; Verbal Learning; base; cohort; diaries; neurophysiology; neuropsychological; novel strategies; response

DESCRIPTION (provided by applicant): Research has shown that patients with insomnia often complain of impaired concentration, impaired memory, and decreased ability to accomplish daily tasks and that these factors worsen as their sleep problems increase in severity. Despite the evidence that insomnia exacts a significant toll on individuals, research has been equivocal as to objectively measured neuropsychological (NP) performance deficits. In this study, NP testing will be combined with functional MRI (FMRI) to investigate and assess cognitive performance in primary insomnia. The specific aims of his study are to: 1) compare patients with insomnia to matched controls on NP test performance, 2) compare patients with insomnia to matched controls on FMRI measures of brain function during cognitive challenges, and 3) examine the relationship between FMRI BOLD signal responses and objective and subjective measures of performance in patients with insomnia, to test whether hypothesized increases in activation represent compensatory responses similar to those observed with sleep deprivation. Avenues for future investigation may include studies of insomnia subtypes (e.g., subjective versus objective) and/or new approaches to treatment of insomnia.

描述（由申请人提供）：研究表明，失眠患者经常抱怨注意力不集中、记忆力减退、完成日常任务的能力下降，并且随着睡眠问题的严重程度增加，这些因素会恶化。尽管有证据表明失眠对个体造成了重大影响，但对于客观测量神经心理学（NP）表现缺陷的研究一直模棱两可。在本研究中，NP测试将结合功能磁共振成像（FMRI）来调查和评估原发性失眠患者的认知表现。他的研究的具体目的是：1)比较失眠患者与匹配的对照组在NP测试中的表现，2)比较失眠患者与匹配的对照组在认知挑战期间的脑功能FMRI测量，以及3)检查FMRI BOLD信号反应与失眠患者客观和主观表现测量之间的关系，以测试假设的激活增加是否代表与睡眠剥夺观察到的代偿反应相似。未来研究的途径可能包括失眠亚型的研究（例如，主观与客观）和/或治疗失眠的新方法。