权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Cortisol in Emotional Processing

皮质醇在情绪处理中的作用

基本信息

批准号：
7247227
负责人：
Keith Daniel Sudheimer
金额：
$ 3.49万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-01 至 2009-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7247227
关键词：
Acute Address Affect Affective Age Amygdaloid structure Anhedonia Area Attention Basal Ganglia Behavior Biological Brain Brain region Clinical Research Cognitive Complex Condition Data Depressed mood Disease Dose Electrophysiology (science)Elevation Emotional Emotional Disturbance Emotions Endocrine System Diseases Etiology Exposure to Fellowship Fire - disasters Functional Imaging Functional Magnetic Resonance Imaging Functional disorder Gender Happiness Hippocampus (Brain)Human Hydrocortisone Imaging Techniques Individual Invasive Investigation Length Literature Magnetic Resonance Imaging Maintenance Major Depressive Disorder Measures Medial Memory Mental Depression Modeling Mood Disorders Names Nature Neurons Neurophysiology - biologic function Neurosciences Patients Pattern Performance Physiological Processes Pituitary-dependent Cushing&apos s disease Play Population Prefrontal Cortex Process Production Publishing Rate Recovery Regulation Relapse Reporting Research Design Resistance Rest Risk Role Series Sex Characteristics Symptoms Techniques Temporal Lobe Thinking Tissues Ventral Striatum Woman Work World Health Organization base burden of illness cingulate cortex depressive symptoms emotional stimulus hydrocortisone receptor hypercortisolemia hypothalamic-pituitary-adrenal axis insight men neuroimaging relating to nervous system research study

项目摘要

DESCRIPTION (provided by applicant): Cortisol has long been suspected to play a critical role in affective disorders, such as depression. However, the effects of cortisol on brain activity associated with emotional processes have not yet been investigated in humans. Therefore, using functional magnetic resonance imaging (fMRI), this series of experiments will aim to characterize the effects of elevated cortisol levels on brain activity associated with emotional processes. These studies will address 1) Effects of acutely elevated circulating cortisol levels 2) Length of exposure effects of elevated cortisol levels and, 3) Gender differences in the effects of cortisol on brain activity associated with emotional processes. The functional circuitry underlying the processing of several different types of affect will be studied using fMRI. The emotion induction paradigms used in these studies will incorporate specific affective processes which are dysfunctional in the depressed state (happiness and sadness). It is hypothesized that during emotional processing elevations in cortisol will result in dose dependant decreases in prefrontal cortex activity and increased amygdala activity.

描述（由申请人提供）：长期以来，人们一直怀疑皮质醇在情感障碍（如抑郁症）中起关键作用。然而，皮质醇对与情绪过程相关的大脑活动的影响尚未在人类中进行过研究。因此，使用功能性磁共振成像（fMRI），这一系列实验的目的是表征皮质醇水平升高对与情绪过程相关的大脑活动的影响。这些研究将解决1）急性升高的循环皮质醇水平的影响2）暴露时间的影响皮质醇水平升高，3）皮质醇对大脑活动的影响与情绪过程的性别差异。几种不同类型的影响处理的功能电路将使用功能磁共振成像研究。在这些研究中使用的情绪诱导范式将纳入特定的情感过程，这是功能失调的抑郁状态（幸福和悲伤）。据推测，在情绪处理过程中，皮质醇的升高将导致剂量依赖性的前额叶皮层活动减少和杏仁核活动增加。