Obesity on Vagal Tone and HbA1c during Pregnancy

怀孕期间肥胖对迷走神经张力和 HbA1c 的影响

• 批准号: 7225598
• 负责人: REBECCA J HELMREICH
• 金额: $ 2.69万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2009-01-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7225598
• 关键词: African; Analysis of Variance; Asians; Birth; Body Weight decreased; Body mass index; Child; Chin; Diabetes Mellitus; Disease; Electrocardiogram; Equilibrium; Ethnic group; Exercise; Fellowship; Fetus; Future; Glycosylated hemoglobin A; Heart; Heart Rate; Hispanics; Hypertension; Incidence; Individual; Intervention Studies; Interview; Lead; Measures; Mothers; Names; Neuro-Oncological Ventral Antigen 2; Non obese; Obesity; Observational Study; Outcome; Oxygen; Patient currently pregnant; Physiological; Pike fish; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnant Women; Premature Birth; Purpose; RQ2; Range; Rate; Regression Analysis; Regulation; Research; Research Personnel; Specific qualifier value; Staging; Stress; Telephone Interviews; Term Birth; Testing; Time; Time Series Analysis; Week; Weight; Weight Gain; Woman; Women' s Health; Yang; comparison group; design; follow-up; improved; infant outcome; millisecond; response; size; statistics

DESCRIPTION (provided by applicant): Obesity is the cause of many adverse pregnancy outcomes and as a result, has a great impact on the health of women and their children. It is hypothesized that during pregnancy obese women will have increased HbA1c, decreased vagal response and oxygenation compared to non-obese women. Forty pregnant women of four major ethnic groups will be observed three times for 30 minutes at 20, 28, and 36 weeks gestation, 20 each with obese and non-obese status determined by their body mass index. The time points for observation have been selected because after 20 weeks the fetus could be viable if born; at 28 weeks the fetus if born would be preterm and at this stage, maternal disorders such as hypertension or diabetes may become clinically apparent with the stress of pregnancy and gestational weight gain; and at 36 weeks the fetus will be close to term birth. Pregnancy complications and infant outcomes will be followed by chart audits and interviews of subjects. The tentative analysis plan will include descriptive statistics, t-tests for two group comparisons, and, repeated measures ANOVA to test the group differences with changes over time. Correlations and regression analyses will be performed to examine the association of obesity and levels of gestational weight gain on vagal response, HbA1c, oxygenation, and pregnancy complications and birth outcomes. For an effect size of 1, 17 subjects will be needed to detect a difference with a power of 80%. Considering a 20% attrition rate, as may occur with preterm birth, 20 women per group is proposed.

说明(申请人提供)：肥胖是许多不良妊娠结局的原因，因此，对妇女及其子女的健康有很大影响。据推测，与非肥胖女性相比，肥胖女性在怀孕期间糖化血红蛋白升高，迷走神经反应和氧合作用降低。来自四个主要民族的40名孕妇将在怀孕20周、28周和36周时进行三次30分钟的观察，每个人20人，由她们的体重指数确定肥胖和非肥胖状态。之所以选择观察时间点，是因为在20周后，如果出生，胎儿可以存活；28周，如果出生，胎儿将早产，在这个阶段，孕妇的疾病，如高血压或糖尿病，可能会随着妊娠压力和妊娠体重增加而在临床上变得明显；36周，胎儿将接近足月出生。在妊娠并发症和婴儿结局之后，将对受试者进行图表审计和访谈。暂定的分析计划将包括描述性统计、两组比较的t检验，以及重复测量ANOVA以测试随时间变化的组差异。将进行相关和回归分析，以检查肥胖和妊娠体重增加水平与迷走神经反应、糖化血红蛋白、氧合作用、妊娠并发症和出生结局的关系。对于1的效应大小，需要17个受试者才能以80%的功率来检测差异。考虑到20%的流失率，就像早产可能发生的那样，建议每组20名妇女。