EFFECTS OF ALBUTEROL ON MUSCLE PROTEIN SYNTHESIS

沙丁胺醇对肌肉蛋白质合成的影响

• 批准号: 7603381
• 负责人: CHARLES LAMBERT
• 金额: $ 0.08万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603381
• 关键词: Adrenergic Agonists; Affect; Agonist; Albuterol; Body mass index; Calpain; Computer Retrieval of Information on Scientific Projects Database; Condition; Degradation Pathway; Elderly; Elderly man; Funding; Grant; Hour; Human; Institution; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Lead; Measures; Messenger RNA; Muscle; Muscle Proteins; Phosphorylation; Protein Biosynthesis; Proteins; Research; Research Personnel; Resources; Site; Source; Therapeutic; United States National Institutes of Health; Work; age related; aged; calpastatin; day; protein degradation; protein metabolism; sarcopenia; synthetic protein; wasting

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Beta-two adrenergic agonists act to increase muscle mass in the elderly but the mechanism(s) in humans for this increase in muscle mass in unknown. We will examine the effects of 8.5 days on albuterol administration (16 mg/24 hours) on mixed muscle protein synthesis and on markers of muscle protein degradation (mRNAs for calpain-1 and calpain-2 and calpastatin). Additionally, we will measure IGF-I and IGF-II mRNA and the phosphorylation state of P70S6Kinase in elderly men (aged 60-85) who have body mass indices that correspond to the presence of sarcopenia. Elucidating the way in which beta two agonists affect muscle protein metabolism may possibly lead to other therapeutic strategies to target specific components of protein synthetic and/or protein degradative pathways that are activated by or deactivated by beta two agonists. Additionally, if we determine the primary site of action of beta two agonists we will be able to hypothesize whether beta two agonists likely work in aging related muscle wasting conditions.

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