HEALTHY AGING AND SENILE DEMENTIA

健康老龄化和老年痴呆症

• 批准号: 7603306
• 负责人: DAVID M. HOLTZMAN
• 金额: $ 1.48万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603306
• 关键词: Alzheimer' s Disease; Amyloid beta-Protein; Apolipoprotein E; Cholesterol Homeostasis; Computer Retrieval of Information on Scientific Projects Database; Funding; Genotype; Grant; Institution; Lipids; Pathogenesis; Play; Research; Research Personnel; Resources; Role; Senile dementia; Source; United States National Institutes of Health; healthy aging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, we are trying to determine whether a subject's apoE genotype influences CNS lipid and cholesterol metabolism as well as its influence on the amyloid beta protein. The amyloid beta protein is felt to play an important role in Alzheimer's disease pathogenesis.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 在这项研究中，我们试图确定受试者的apoE基因型是否影响CNS脂质和胆固醇代谢以及其对淀粉样β蛋白的影响。 淀粉样β蛋白被认为在阿尔茨海默病的发病机制中起重要作用。