HEALTHY AGING AND SENILE DEMENTIA
HEALTHY AGING AND SENILE DEMENTIA
批准号:
7603306
负责人:
DAVID M. HOLTZMAN
金额:
$1.48万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-04-01 至 2007-09-16
关键词:
Alzheimer&aposs DiseaseAmyloid beta-ProteinApolipoprotein ECholesterol HomeostasisComputer Retrieval of Information on Scientific Projects DatabaseFundingGenotypeGrantInstitutionLipidsPathogenesisPlayResearchResearch PersonnelResourcesRoleSenile dementiaSourceUnited States National Institutes of Healthhealthy aging
中文摘要
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
在这项研究中,我们试图确定受试者的apoE基因型是否影响CNS脂质和胆固醇代谢以及其对淀粉样β蛋白的影响。 淀粉样β蛋白被认为在阿尔茨海默病的发病机制中起重要作用。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
In this study, we are trying to determine whether a subject's apoE genotype influences CNS lipid and cholesterol metabolism as well as its influence on the amyloid beta protein. The amyloid beta protein is felt to play an important role in Alzheimer's disease pathogenesis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Cerebral amyloid angiopathy: Role of ApoE, innate immunity, and meningeal lymphatics
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批准号:10674679
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项目类别:
-
资助金额:$62.0万
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财政年份:2022
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负责人:DAVID M. HOLTZMAN
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依托单位:
APOE effects on glial lipid metabolism and 25-hydroxycholesterol: Effects on aging and AD-related pathology
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批准号:10667466
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项目类别:
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资助金额:$53.02万
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财政年份:2021
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负责人:DAVID M. HOLTZMAN
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依托单位:
APOE effects on glial lipid metabolism and 25-hydroxycholesterol: Effects on aging and AD-related pathology
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批准号:10407944
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项目类别:
-
资助金额:$54.01万
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财政年份:2021
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负责人:DAVID M. HOLTZMAN
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依托单位:
Administration Core
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批准号:10622634
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项目类别:
-
资助金额:$80.27万
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财政年份:2020
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负责人:DAVID M. HOLTZMAN
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依托单位:
Alzheimer's Disease Research Center
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批准号:10622633
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项目类别:
-
资助金额:$307.63万
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财政年份:2020
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负责人:DAVID M. HOLTZMAN
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依托单位:
Sleep and Circadian Rhythms in Alzheimer Disease: Potential bi-directional relationship with tau
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批准号:9815588
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项目类别:
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资助金额:$369.43万
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财政年份:2019
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负责人:DAVID M. HOLTZMAN
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依托单位:
Nervous System Development and Injury
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批准号:9386458
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项目类别:
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资助金额:$0.83万
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财政年份:2016
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负责人:DAVID M. HOLTZMAN
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依托单位:
Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease
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批准号:8779836
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项目类别:
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资助金额:$59.46万
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财政年份:2014
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负责人:DAVID M. HOLTZMAN
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依托单位:
Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease
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批准号:9060227
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项目类别:
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资助金额:$55.3万
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财政年份:2014
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负责人:DAVID M. HOLTZMAN
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依托单位:
Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease
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批准号:9814735
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项目类别:
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资助金额:$376.01万
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财政年份:2014
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负责人:DAVID M. HOLTZMAN
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依托单位:
Administrative Core
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批准号:10006905
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项目类别:
-
资助金额:$7.01万
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财政年份:2012
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负责人:DAVID M. HOLTZMAN
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依托单位:
Regional, Synpatic, Cellular Modulation of Abeta Metabolism
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批准号:8642679
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项目类别:
-
资助金额:$112.94万
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财政年份:2012
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负责人:DAVID M. HOLTZMAN
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依托单位:
Dynamic Regulation of Amyloid-^ in the CNS
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批准号:8331629
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项目类别:
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资助金额:$29.84万
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财政年份:2012
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负责人:DAVID M. HOLTZMAN
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依托单位:
Regional, Synpatic, Cellular Modulation of Abeta Metabolism
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批准号:8838268
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项目类别:
-
资助金额:$112.94万
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财政年份:2012
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负责人:DAVID M. HOLTZMAN
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依托单位:
Effects of the Sleep/Wake Cycle on A-Beta, Tau and Spreading
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批准号:10006907
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项目类别:
-
资助金额:$38.27万
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财政年份:2012
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负责人:DAVID M. HOLTZMAN
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依托单位:
Neuronal LRP1 and HSPG in Pathological Spreading of A-Beta and Tau
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批准号:10246278
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项目类别:
-
资助金额:$39.36万
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财政年份:2012
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负责人:DAVID M. HOLTZMAN
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依托单位:
Administrative Core
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批准号:10246274
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项目类别:
-
资助金额:$6.79万
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财政年份:2012
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负责人:DAVID M. HOLTZMAN
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依托单位:
Neuronal LRP1 and HSPG in Pathological Spreading of A-Beta and Tau
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批准号:10006909
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项目类别:
-
资助金额:$39.91万
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财政年份:2012
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负责人:DAVID M. HOLTZMAN
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依托单位:
Regional, Synpatic, Cellular Modulation of Abeta Metabolism
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批准号:8467068
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项目类别:
-
资助金额:$110.69万
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财政年份:2012
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负责人:DAVID M. HOLTZMAN
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依托单位:
Regional, Synaptic, Cellular Modulation of Abeta Metabolism
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批准号:9764499
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项目类别:
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资助金额:$146.62万
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财政年份:2012
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负责人:DAVID M. HOLTZMAN
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依托单位:
国内基金
海外基金
新型F-18标记香豆素衍生物PET探针的研制及靶向Alzheimer's Disease 斑块显像研究
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批准号:81000622
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项目类别:青年科学基金项目
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资助金额:20.0万元
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批准年份:2010
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负责人:梁胜
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依托单位:
阿尔茨海默病(Alzheimer's disease,AD)动物模型构建的分子机理研究
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批准号:31060293
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项目类别:地区科学基金项目
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资助金额:26.0万元
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批准年份:2010
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负责人:郭亚芬
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依托单位:
跨膜转运蛋白21(TMP21)对引起阿尔茨海默病(Alzheimer'S Disease)的γ分泌酶的作用研究
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批准号:30960334
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项目类别:地区科学基金项目
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资助金额:22.0万元
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批准年份:2009
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负责人:董贵成
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依托单位: