GASTRIC BYPASS EFFECTS ON MYOCARDIAL METABOLISM

胃绕道术对心肌代谢的影响

• 批准号: 7603351
• 负责人: LINDA Ruth PETERSON
• 金额: $ 0.39万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603351
• 关键词: Affect; American; Body Weight decreased; Body mass index; Body measure procedure; Cardiovascular system; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Functional disorder; Funding; Gastric Bypass; Grant; Heart failure; Human; Incidence; Institution; Insulin Resistance; Kinetics; Left Ventricular Remodeling; Link; Measures; Metabolism; Myocardial; Nonesterified Fatty Acids; Obesity; Oxygen; Research; Research Personnel; Resources; Source; Structure; Sudden Death; United States National Institutes of Health; animal data; fatty acid metabolism; human study; oxidation; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity affects more than 43 million Americans and is associated with an increased incidence of heart failure, sudden death, and cardiovascular death. We have shown that increasing obesity, as measured by body mass index (BMI), is independently associated with LV structural and functional changes, specifically, concentric LV remodeling and decreased load-independent measures of diastolic and systolic function and decreased oxygen efficiency (a hallmark of heart failure). Furthermore, we have shown that the insulin resistance that often accompanies obesity in independently related measures of myocardial free fatty acid (FFA) metabolism uptake (MFAUp), utilization (MFAU), and oxidation (MFAO). Moreover, there are data from animal studies and preliminary human studies that demonstrate that excessive myocardial fatty acid metabolism is linked to detrimental myocardial structural changes and may directly contribute to LV dysfunction. In order to increase our understanding of these relationships between BMI or insulin resistance and myocardial metabolism, efficiency, structure, and function in humans, we propose to study the effect of gastric bypass-induced weight loss and consequent improvement in insulin resistance on theses myocardial variables. We further propose to determine how the expected changes in myocardial fatty acid metabolism relate to changes in total body FFA kinetics and delivery.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肥胖影响了4300多万美国人，并与心力衰竭、猝死和心血管死亡的发生率增加有关。我们已经证明，以体重指数(BMI)衡量的肥胖增加与左室结构和功能的变化独立相关，特别是向心性左室重构，舒缩功能的负荷非依赖性指标降低，以及氧效率降低(心力衰竭的一个标志)。此外，我们已经证明，胰岛素抵抗通常伴随着肥胖的独立相关指标心肌游离脂肪酸(FFA)代谢摄取(MFAUp)、利用(MFAU)和氧化(MFAO)。此外，有来自动物研究和初步人类研究的数据表明，过度的心肌脂肪酸代谢与有害的心肌结构变化有关，并可能直接导致左心功能不全。为了加深我们对BMI或胰岛素抵抗与人体心肌代谢、效率、结构和功能之间的关系的了解，我们建议研究胃旁路手术引起的体重减轻和胰岛素抵抗的改善对这些心肌变量的影响。我们进一步建议确定心肌脂肪酸代谢的预期变化如何与全身FFA动力学和递送的变化相关。