OBESITY'S EFFECT ON MYOCARDIAL METABOLISM AND IT'S REGULATION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。肥胖症在美国很流行，影响了3400多万人。然而，关于肥胖对心脏影响的数据很少，尽管肥胖者心血管（CV）死亡的风险增加。众所周知，肥胖，特别是上身肥胖，与CV疾病和左心室（LV）结构异常（如肥大和衰竭）的风险因素相关;然而，肥胖对心脏代谢功能的影响尚不清楚。我们假设，由于心脏代谢在与LV肥大和衰竭相关的其他疾病中是异常的（例如，高血压），肥胖受试者心脏代谢将异常。因此，试点项目的具体目标是：确定上身肥胖的影响（即，BMI>30 kg/m2，女性腰围>或= 35英寸，男性腰围>或= 40英寸）对人体心脏代谢的影响，将这种代谢与心脏代谢可用的底物水平和循环合成代谢激素水平相关联，并将这些值与瘦型受试者（BMI <25 kg/m2）的值进行比较。为了研究这一点，我们计划招募14名健康的肥胖受试者。我们将测量心脏代谢水平（即，中链脂肪酸、葡萄糖和乳酸水平）、心脏大小、体脂百分比，以及（使用正电子发射断层扫描或“PET”扫描）确定两组中的心脏血流量、总代谢率和有氧脂肪酸代谢。将在代谢底物的背景下分析心脏代谢率和脂肪酸代谢率。然后，我们将这些肥胖个体的心脏血流量、代谢和脂肪酸代谢的测量值与目前资助项目下研究的14名年龄匹配的健康瘦型（BMI<= 25）个体的数据进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is in epidemic proportions in the United States, affecting more than 34 million people. However, there is a paucity of data regarding obesity's effect on the heart, even though obese people have an increased risk of cardiovascular (CV) death. It is know that obesity, particularly upper body obesity, is associated with risk factors for CV disease and left ventricular (LV) structural abnormalities such as hypertrophy and failure; however , the effect of obesity on cardiac metabolic function is unknown. We hypothesize that since cardiac metabolism is abnormal in other conditions associated with LV hypertrophy and failure (e.g., hypertension), that cardiac metabolism will be abnormal in obese subjects. Thus, the specific aim of the pilot project is: To determine the effect of upper body obesity (i.e., a BMI>30 kg/m2 and a waist circumference> or = 35 inches in women and > or = 40 inches in men) on cardiac metabolism in humans, to relate this metabolism to the levels of substrate available for cardiac metabolism and circulating anabolic hormone levels, and to compare these values with those of lean subjects (BMI < 25kg/m2). In order to investigate this, we plan to recruit fourteen otherwise healthy, obese subjects. We will measure cardiac metabolic levels (i.e., medium-chain fatty acid, glucose, and lactate levels), cardiac size, percent body fat, and (using positron emission tomography or "PET" scans) determine cardiac blood flow, overall metabolic rate, and aerobic fatty acid metabolism in both groups. The cardiac metabolic rate and fatty acid metabolic rates will be analyzed in the context of the metabolic substrate. We will then compare the measured values of cardiac blood flow, metabolism , and fatty acid metabolism of these obese individuals with date from 14 age-matched, healthy lean (BMI<= 25) individuals that were studied under currently funded projects.